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01.06.2014 | Review Article

Bacteriophage Polysaccharide Depolymerases and Biomedical Applications

verfasst von: Jianlong Yan, Jiaoxiao Mao, Jianping Xie

Erschienen in: BioDrugs | Ausgabe 3/2014

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Abstract

Polysaccharide depolymerase, a polysaccharide hydrolase encoded by bacteriophages (or ‘phages’), can specifically degrade the macromolecule carbohydrates of the host bacterial envelope. This enzyme assists the bacteriophage in adsorbing, invading, and disintegrating the host bacteria. Polysaccharide depolymerase activity continues even within biofilms. This effectiveness means phages are promising candidates for novel antibiotic scaffolds. A comprehensive compendium of bacteriophage polysaccharide depolymerases has been compiled, together with their potential biomedical applications, such as novel antibiotics, adjuvants for antibiotics, bacterial biofilm disruptants, and diagnostic kits.

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Titel: Bacteriophage Polysaccharide Depolymerases and Biomedical Applications
verfasst von: Jianlong Yan
Jiaoxiao Mao
Jianping Xie
Publikationsdatum: 01.06.2014
Verlag: Springer International Publishing
Erschienen in: BioDrugs / Ausgabe 3/2014
Print ISSN: 1173-8804
Elektronische ISSN: 1179-190X
DOI: https://doi.org/10.1007/s40259-013-0081-y

Springer Medizin

Abstract

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