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CNS Drugs

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01.08.2016 | Leading Article

Aβ-Degrading Proteases: Therapeutic Potential in Alzheimer Disease

verfasst von: Malcolm A. Leissring

Erschienen in: CNS Drugs | Ausgabe 8/2016

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Abstract

The amyloid β-protein (Aβ) plays an indispensable role in the pathogenesis of Alzheimer disease (AD). Aβ is subject to proteolytic degradation by a diverse array of peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A growing number of AβDPs have been identified that impact Aβ powerfully and in a surprising variety of ways. As such, AβDPs hold considerable therapeutic potential for the treatment and/or prevention of AD. Here, we critically review the relative merits of therapeutic strategies targeting AβDPs compared with current Aβ-lowering strategies focused on immunotherapies and pharmacological modulation of Aβ-producing enzymes. Several innovative advances have increased considerably the feasibility of delivering AβDPs to the brain or enhancing their activity in a non-invasive manner. We argue that therapies targeting AβDPs offer numerous potential advantages that should be explored through continued research into this promising field.

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Titel: Aβ-Degrading Proteases: Therapeutic Potential in Alzheimer Disease
verfasst von: Malcolm A. Leissring
Publikationsdatum: 01.08.2016
Verlag: Springer International Publishing
Erschienen in: CNS Drugs / Ausgabe 8/2016
Print ISSN: 1172-7047
Elektronische ISSN: 1179-1934
DOI: https://doi.org/10.1007/s40263-016-0364-1

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