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Drug Safety
Erschienen in: Drug Safety 4/2014

01.04.2014 | Original Research Article

Self-Medication with Over-the-Counter and Prescribed Drugs Causing Adverse-Drug-Reaction-Related Hospital Admissions: Results of a Prospective, Long-Term Multi-Centre Study

verfasst von: Sven Schmiedl, Marietta Rottenkolber, Joerg Hasford, Dominik Rottenkolber, Katrin Farker, Bernd Drewelow, Marion Hippius, Karen Saljé, Petra Thürmann

Erschienen in: Drug Safety | Ausgabe 4/2014

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Abstract

Background

Self-medication, including both the use of over-the-counter (OTC) drugs and the use of formerly prescribed drugs taken without a current physician’s recommendation, is a public health concern; however, little data exist regarding the actual risk.

Objective

We aimed to analyse self-medication-related adverse drug reactions (ADRs) leading to hospitalisation.

Methods

In a multi-centre, observational study covering a hospital catchment area of approximately 500,000 inhabitants, we analysed self-medication-related ADRs leading to hospital admissions in internal medicine departments. Data of patients with ADRs were comprehensively documented, and ADR causality was assessed using Bégaud’s algorithm. The included ADRs occurred between January 2000 and December 2008 and were assessed to be at least ‘possibly’ drug related.

Results

Of 6,887 patients with ADRs, self-medication was involved in 266 (3.9 %) patients. In 143 (53.8 %) of these patients, ADRs were due to OTC drugs. Formerly prescribed drugs and potential OTC drugs accounted for the remaining ADRs. Most self-medication-related ADRs occurred in women aged 70–79 years and in men aged 60–69 years. Self-medication-related ADRs were predominantly gastrointestinal complaints caused by non-steroidal anti-inflammatory drugs (most frequently OTC acetylsalicylic acid [ASA, aspirin]). In 102 (38.3 %) of the patients with self-medication-related ADRs, a relevant drug–drug interaction (DDI), occurring between a self-medication and a prescribed medication, was present (most frequently ASA taken as an OTC drug and prescribed diclofenac).

Conclusion

In the general population, self-medication plays a limited role in ADRs leading to hospitalisation. However, prevention strategies focused on elderly patients and patients receiving interacting prescribed drugs would improve patient safety.
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Metadaten
Titel
Self-Medication with Over-the-Counter and Prescribed Drugs Causing Adverse-Drug-Reaction-Related Hospital Admissions: Results of a Prospective, Long-Term Multi-Centre Study
verfasst von
Sven Schmiedl
Marietta Rottenkolber
Joerg Hasford
Dominik Rottenkolber
Katrin Farker
Bernd Drewelow
Marion Hippius
Karen Saljé
Petra Thürmann
Publikationsdatum
01.04.2014
Verlag
Springer International Publishing
Erschienen in
Drug Safety / Ausgabe 4/2014
Print ISSN: 0114-5916
Elektronische ISSN: 1179-1942
DOI
https://doi.org/10.1007/s40264-014-0141-3

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