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Drugs
Erschienen in: Drugs 16/2016

01.10.2016 | Adis Drug Evaluation

Sofosbuvir/Velpatasvir: A Review in Chronic Hepatitis C

verfasst von: Sarah L. Greig

Erschienen in: Drugs | Ausgabe 16/2016

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Abstract

A once-daily, single-tablet, pangenotypic regimen comprising the hepatitis C virus (HCV) NS5B polymerase inhibitor sofosbuvir and the HCV NS5A inhibitor velpatasvir (sofosbuvir/velpatasvir; Epclusa®) was recently approved for the treatment of adults with chronic HCV genotype 1, 2, 3, 4, 5 or 6 infection in the USA, EU and Canada. In the phase III ASTRAL trials, once-daily oral sofosbuvir/velpatasvir for 12 weeks provided very high rates of sustained virological response at 12 weeks post treatment (SVR12) in treatment-naive and -experienced patients with chronic HCV genotype 1–6 infection, including those with compensated cirrhosis or HIV-1 co-infection. High SVR12 rates were also observed with sofosbuvir/velpatasvir plus ribavirin for 12 weeks in patients with chronic HCV genotype 1–6 infection and decompensated cirrhosis. Sofosbuvir/velpatasvir was generally well tolerated, with low rates of adverse events. Thus, sofosbuvir/velpatasvir represents a valuable treatment option in adults with chronic HCV genotype 1–6 infection, including those with compensated or decompensated cirrhosis, previous treatment experience or HIV-1 co-infection.
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Metadaten
Titel
Sofosbuvir/Velpatasvir: A Review in Chronic Hepatitis C
verfasst von
Sarah L. Greig
Publikationsdatum
01.10.2016
Verlag
Springer International Publishing
Erschienen in
Drugs / Ausgabe 16/2016
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-016-0648-2

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