Background
Methods
Subjects
Laboratory methods
Statistical analyses
Results
Without metabolic syndrome | With metabolic syndrome |
p
| |
---|---|---|---|
n | 2206 | 932 | |
age (y) | 49.4 ± 8.4 | 54.2 ± 8.1 |
<0.0001
|
men | 1044 (47.3) | 553 (59.3) |
<0.0001
|
BMI (kg/m2) | 24.8 ± 3.6 | 29.9 ± 4.7 |
<0.0001
|
Waist (cm) | 85.3 ± 11.3 | 101.5 ± 11.6 |
<0.0001
|
Cholesterol (mmol/l) | 5.8 ± 1.0 | 6.1 ± 1.1 |
<0.0001
|
Triglycerides (mmol/l) | 1.00 ± 0.52 | 2.20 ± 2.32 |
<0.0001
|
HDL (mmol/l) | 1.58 ± 0.43 | 1.19 ± 0.34 |
<0.0001
|
Glucose (mmol/l) | 5.20 ± 0.76 | 5.95 ± 1.30 |
<0.0001
|
Diabetes (%) | 2.4 | 19.5 |
<0.0001
|
SBP (mm Hg) | 125.7 ± 15.8 | 140.6 ± 16.9 |
<0.0001
|
DBP (mm Hg) | 79.0 ± 10.1 | 87.9 ± 11.2 |
<0.0001
|
Smoking |
0.032
| ||
never | 1069 (48.5) | 432 (46.4) | |
former | 629 (28.5) | 308 (33.0) | |
current | 508 (23.0) | 192 (20.6) | |
Physical activity |
<0.0001
| ||
none | 449 (20.4) | 244 (26.3) | |
light | 1058 (48.0) | 490 (52.7) | |
intense | 697(31.6) | 195 (21.0) | |
Alcohol intake |
0.0013
| ||
Q1 | 760 (34.5) | 303 (32.5) | |
Q2 | 574 (26.0) | 201 (21.6) | |
Q3 | 535 (24.3) | 241 (25.9) | |
Q4 | 337 (15.2) | 187 (20.0) | |
Educational level |
<0.0001
| ||
low | 433 (19.6) | 312 (33.5) | |
intermediate | 952 (43.2) | 410 (44.0) | |
high | 821 (37.2) | 210 (22.5) |
APOA5 Ser19Trp
|
APOA5 -12,238 T>C
|
APOA4 Thr347Ser
|
APOC3 -482 C>T
|
APOC3 3238 C>G
| |
---|---|---|---|---|---|
APOA5 Ser19Trp
| - |
-0.85
|
-1
|
-0.73
|
-0.41
|
APOA5 -12,238 T>C
|
0.02
| - |
0.95
|
0.29
|
-0.58
|
APOA4 Thr347Ser
|
0.02
|
0.40
| - |
0.45
|
-0.92
|
APOC3 -482 C>T
|
0.01
|
0.06
|
0.13
| - |
0.91
|
APOC3 3238 C>G
|
0.00
|
0.02
|
0.02
|
0.23
| - |
APOA5 Ser19Trp
| Ser19Ser | Ser19Trp | Trp19Trp |
p
|
p
a
|
p
b
|
---|---|---|---|---|---|---|
Waist (cm) | 85 ± 11 | 84 ± 11 | 81 ± 8 |
0.49
|
0.23
|
0.77
|
TG (mmol/l) d
| 1.26 ± 1.1 | 1.59 ± 2.4 | 2.46 ± 2.3 |
<0.0001
c
|
<0.0001
c
|
0.07
c
|
HDL (mmol/l) d
| 1.48 ± 0.4 | 1.49 ± 0.5 | 1.2 ± 0.5 |
0.56
|
0.78
|
0.59
|
Glucose (mmol/l) e
| 5.4 ± 1 | 5.4 ± 0.8 | 5.5 ± 0.4 |
0.72
|
0.43
|
0.83
|
SBP (mm Hg) f
| 129 ± 17 | 131 ± 18 | 135 ± 13 |
0.081
|
0.03
|
0.47
|
DBP (mm Hg) f
| 81 ± 11 | 82 ± 10 | 84 ± 10 |
0.082
|
0.03
|
0.39
|
APOA5 -12,238 T>C
|
TT
|
TC
|
CC
| |||
Waist (cm) | 85 ± 11 | 85 ± 11 | 85 ± 11 |
0.49
|
0.23
|
0.15
|
TG (mmol/l) d
| 1.31 ± 1.0 | 1.29 ± 1.4 | 1.32 ± 1.9 |
0.01
c
|
0.003
c
|
0.08
c
|
HDL (mmol/l) d
| 1.47 ± 0.4 | 1.49 ± 0.4 | 1.52 ± 0.5 |
0.04
|
0.02
|
0.10
|
Glucose (mmol/l) e
| 5.4 ± 1 | 5.4 ± 1.1 | 5.3 ± 0.8 |
0.31
|
0.52
|
0.15
|
SBP (mm Hg) f
| 129 ± 17 | 129 ± 18 | 129 ± 17 |
0.24
|
0.11
|
0.30
|
DBP (mm Hg) f
| 81 ± 11 | 81 ± 11 | 81 ± 10 |
0.79
|
0.54
|
0.49
|
APOA4 Thr347Ser
|
Thr347Thr
|
Thr347Ser
|
Ser347Ser
| |||
Waist (cm) | 85 ± 11 | 86 ± 11 | 86 ± 11 |
0.64
|
0.71
|
0.39
|
TG (mmol/l) d
| 1.31 ± 1 | 1.30 ± 1.8 | 1.22 ± 0.8 |
0.11
c
|
0.04
c
|
0.69
c
|
HDL (mmol/l) d
| 1.48 ± 0.4 | 1.49 ± 0.4 | 1.55 ± 0.5 |
0.24
|
0.24
|
0.09
|
Glucose (mmol/l) e
| 5.4 ± 1.1 | 5.4 ± 0.9 | 5.2 ± 0.7 |
0.44
|
0.63
|
0.20
|
SBP (mm Hg) f
| 130 ± 18 | 129 ± 17 | 127 ± 16 |
0.09
|
0.03
|
0.82
|
DBP (mm Hg) f
| 81 ± 11 | 81 ± 11 | 81 ± 10 |
0.92
|
0.83
|
0.84
|
APOC3 -482 C>T
|
CC
|
CT
|
TT
| |||
Waist (cm) | 85 ± 11 | 85 ± 11 | 85 ± 11 |
0.75
|
0.78
|
0.49
|
TG (mmol/l) d
| 1.27 ± 1 | 1.34 ± 1 | 1.33 ± 1 |
0.09
c
|
0.04
c
|
0.07
c
|
HDL (mmol/l) d
| 1.47 ± 0.4 | 1.49 ± 0.4 | 1.51 ± 0.4 |
0.68
|
0.54
|
0.66
|
Glucose (mmol/l) e
| 5.4 ± 1 | 5.4 ± 1 | 5.4 ± 0.8 |
0.93
|
0.78
|
0.87
|
SBP (mm Hg) f
| 129 ± 17 | 129 ± 18 | 128 ± 17 |
0.47
|
0.45
|
0.28
|
DBP (mm Hg) f
| 81 ± 10 | 81 ± 11 | 81 ± 11 |
0.93
|
0.72
|
0.85
|
APOC3 3238 C>G
|
CC
|
CG
|
GG
| |||
Waist (cm) | 85 ± 11 | 86 ± 11 | 84 ± 15 |
0.25
|
0.1
|
0.66
|
TG (mmol/l) d
| 1.27 ± 1.4 | 1.44 ± 1.2 | 1.56 ± 1.2 |
<0.0001
c
|
<0.0001
c
|
0.05
c
|
HDL (mmol/l) d
| 1.49 ± 0.4 | 1.47 ± 0.4 | 1.43 ± 0.4 |
0.15
|
0.6
|
0.29
|
Glucose (mmol/l) e
| 5.4 ± 1 | 5.4 ± 0.8 | 5.5 ± 0.6 |
0.55
|
0.35
|
0.79
|
SBP (mm Hg) f
| 129 ± 17 | 129 ± 17 | 134 ± 21 |
0.19
|
0.52
|
0.28
|
DBP (mm Hg) f
| 81 ± 11 | 81 ± 11 | 84 ± 12 |
0.12
|
0.37
|
0.21
|
Haplotype | Frequency | Δ TG |
p
|
---|---|---|---|
CTACC | 0.454 | reference | - |
CCACC | 0.130 | 0.037 | 0.13 |
CCTTC | 0.118 | 0.003 | 0.93 |
CTATG | 0.079 | 0.165 | <10-6
|
CCTCC | 0.075 | -0.004 | 0.92 |
GTACC | 0.050 | 0.165 | <10-6
|
CTATC | 0.043 | -0.021 | 0.71 |
CCATC | 0.022 | -0.013 | 0.83 |
SNP |
p
| |||
---|---|---|---|---|
APOA5 Ser19Trp
| Ser19Ser | Ser19Trp | Trp19Trp | |
Without MS | 1960 (88.8) | 241 (10.9) | 5 (0.2) |
0.10
|
With MS | 807 (86.6) | 120 (12.9) | 5 (0.5) | |
APOA5 -12,238 T>C
| TT | CT | CC | |
Without MS | 912 (41.3) | 995 (45.1) | 299 (13.5) |
0.026
|
With MS | 413 (44.3) | 424 (45.5) | 95 (10.2) | |
APOA4 Thr347Ser
| Thr347Thr | Thr347Ser | Ser347Ser | |
Without MS | 1412 (64.0) | 702 (31.8) | 92 (4.2) |
0.034
|
With MS | 627 (67.3) | 282 (30.3) | 23 (2.5) | |
APOC3 -482 C>T
| CC | CT | TT | |
Without MS | 1148 (52.0) | 894 (40.5) | 164 (7.4) |
0.26
|
With MS | 508 (54.5) | 349 (37.4) | 75 (8.0) | |
APOC3 3238 C>G
| CC | CG | GG | |
Without MS | 1799 (81.5) | 388 (17.6) | 19 (0.86) |
0.71
|
With MS | 750 (80.5) | 172 (18.4) | 10 (1.1) |
SNP | OR | [95% CI] |
p
|
---|---|---|---|
APOA5 Ser19Trp
| 1.30 | [1.03–1.66] |
0.03
|
APOA5 -12,238 T>C
| 0.81 | [0.69–0.95] |
0.01
|
APOA4 Thr347Ser
| 0.84 | [0.70–0.99] |
0.04
|
APOC3 -482 C>T
| 0.89 | [0.76–1.06] |
0.17
|
APOC3 3238 C>G
| 1.03 | [0.84–1.26] |
0.76
|