Background
Methods
Design
Setting and participants
Assessments
Data analysis
Ethical considerations
Results
Cohort characteristics
Variable | Mean ± SD or n(%) |
---|---|
Age (years) | 67.8+13.7 |
Male (%) | 39 (68%) |
Enrolled (hours) | 52.6 ± 21.6 |
Hypertension | 35 (61%) |
Atrial fibrillation | 10 (18%) |
Hypercholesterolaemia | 11 (19%) |
Diabetes | 13 (23%) |
Smoking | 21 (37%) |
Aetiology | |
Large vessel | 6 (11%) |
Small vessel | 8 (14%) |
Cardioembolic | 24 (42%) |
Other | 1 (2%) |
Unknown | 18 (32%) |
Syndrome | |
Total anterior circulation | 14 (25%) |
Partial anterior circulation | 26 (46%) |
Lacunar | 11 (19%) |
Posterior circulation | 6 (11%) |
Systolic blood pressure (mmHg) | 142.1 ± 19.3 |
Diastolic blood pressure (mmHg) | 80.2 ± 11.2 |
NIH stroke scale score | 8.5 ± 7.8 |
Modified Rankin scale score | |
0-3 | 17 (30%) |
4-5 | 40 (70%) |
Modified Barthel index score | 39.3 ± 33.9 |
Glucose (mmol/L) | 6.3 ± 1.6 |
Homocysteine (umol/L) | 9.9 ± 3.8 |
High sensitivity-CRP (mg/L) | 15.7 ± 27.9 |
Fibrinogen (g/L) | 4.2 ± 1.2 |
E-selectin (ng/mL) | 30.5 ± 34.0 |
von Willebrand Factor (%) | 158.7 ± 61.6 |
S100B (ug/L) | 0.5 ± 0.8 |
F2-Isoprostanes (nmol/L) | 3.2 ± 4.2 |
Lesion area (mm2) | 1001.9 ± 1359.8 |
Factors associated with S100B concentrations
Predictor | B | SE B |
B
| p |
---|---|---|---|---|
Univariate Relationships | ||||
Age | 0.01 | 0.01 | 0.27 | 0.05 |
Gender | -0.10 | 0.18 | -0.07 | 0.60 |
Hours to enrolment | 0.00 | 0.00 | 0.07 | 0.62 |
Hypertension | -0.06 | 0.17 | -0.05 | 0.73 |
Atrial fibrillation | 0.19 | 0.22 | 0.12 | 0.40 |
Hypercholesterolaemia | -0.20 | 0.22 | -0.12 | 0.37 |
Diabetes | 0.02 | 0.20 | 0.02 | 0.90 |
Smoking history | -0.09 | 0.17 | -0.07 | 0.60 |
Aetiology | -0.03 | 0.06 | -0.06 | 0.66 |
Clinical syndrome | -0.43 | 0.08 | -0.61 | 0.00 |
Systolic blood pressure | 0.00 | 0.00 | 0.00 | 0.99 |
Diastolic blood pressure | 0.00 | 0.01 | -0.07 | 0.58 |
NIHSS score | 0.56 | 0.20 | 0.36 | 0.01 |
Modified Rankin | 0.00 | 0.00 | 1.10 | 0.28 |
Modified Barthel | -0.01 | 0.00 | -0.36 | 0.01 |
Glucose | 1.52 | 0.84 | 0.25 | 0.08 |
Homocysteine | 0.01 | 0.52 | 0.00 | 0.99 |
Hs-CRP | 0.56 | 0.12 | 0.55 | 0.00 |
Fibrinogen | 0.10 | 0.07 | 0.20 | 0.16 |
E-Selectin | -0.09 | 0.29 | -0.04 | 0.75 |
von Willebrand factor activity | 0.00 | 0.00 | 2.26 | 0.03 |
F2-Isoprostanes | 0.04 | 0.31 | 0.02 | 0.89 |
Lesion area | 0.73 | 0.08 | 0.77 | 0.00 |
Final multivariate model
| ||||
Hs-CRP | 0.42 | 0.07 | 0.41 | 0.00 |
Lesion area | 0.65 | 0.07 | 0.69 | 0.00 |