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Alzheimer's Research & Therapy

Erschienen in:

01.06.2009 | Review

Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND)

verfasst von: Blossom CM Stephan, Fiona E Matthews, Kay-Tee Khaw, Carole Dufouil, Carol Brayne

Erschienen in: Alzheimer's Research & Therapy | Ausgabe 1/2009

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Abstract

Identifying the causes of dementia is important in the search for effective preventative and treatment strategies. The concept of mild cognitive impairment (MCI), as prodromal dementia, has been useful but remains controversial since in population-based studies it appears to be a limited predictor of progression to dementia. Recognising the relative contribution of neurodegenerative and vascular causes, as well as their interrelationship, may enhance predictive accuracy. The concept of vascular cognitive impairment (VCI) has been introduced to describe the spectrum of cognitive change related to vascular causes from early cognitive decline to dementia. A recent review of this concept highlighted the need for diagnostic criteria that encompass the full range of the VCI construct. However, very little is known regarding the mildest stage of VCI, generally termed 'vascular cognitive impairment, no dementia' (VCIND). Whether mild cognitive change in the context of neurodegenerative pathologies is distinct from that in the context of cerebrovascular diseases is not known. This is key to the definition of VCIND and whether it is possible to identify this state. Distinguishing between vascular (that is, VCIND) and non-vascular (that is, MCI) cognitive disorders and determining how well each might predict dementia may not be possible due to the overlap in pathologies observed in the older population. Here, we review the concept of VCIND in an effort to identify recent developments and areas of controversy in nosology and the application of VCIND for screening individuals at increased risk of dementia secondary to vascular disease and its risk factors.

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Titel: Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND)
verfasst von: Blossom CM Stephan
Fiona E Matthews
Kay-Tee Khaw
Carole Dufouil
Carol Brayne
Publikationsdatum: 01.06.2009
Verlag: BioMed Central
Erschienen in: Alzheimer's Research & Therapy / Ausgabe 1/2009
Elektronische ISSN: 1758-9193
DOI: https://doi.org/10.1186/alzrt4

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