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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 3/2004

01.06.2004 | Review

Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link

verfasst von: Anindya Gupta, Alan J Silman

Erschienen in: Arthritis Research & Therapy | Ausgabe 3/2004

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Abstract

The present review attempts to reconcile the dichotomy that exists in the literature in relation to fibromyalgia, in that it is considered either a somatic response to psychological stress or a distinct organically based syndrome. Specifically, the hypothesis explored is that the link between chronic stress and the subsequent development of fibromyalgia can be explained by one or more abnormalities in neuroendocrine function. There are several such abnormalities recognised that both occur as a result of chronic stress and are observed in fibromyalgia. Whether such abnormalities have an aetiologic role remains uncertain but should be testable by well-designed prospective studies.
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Literatur
1.
Marder WD, Meenan RF, Felson DT, Reichlin M, Birnbaum NS, Croft JD, Dore RK, Kaplan H, Kaufman RL, Stobo JD: The present and future adequacy of rheumatology manpower. A study of health care needs and physician supply. Arthritis Rheum. 1991, 34: 1209-1217.PubMed
2.
Aronoff GM: Myofascial pain syndrome and fibromyalgia: a critical assessment and alternate view. Clin J Pain. 1998, 14: 74-85. 10.1097/00002508-199803000-00011.PubMed
3.
Aaron LA, Bradley LA, Alarcon GS, Triana-Alexander M, Alexander RW, Martin MY, Alberts KR: Perceived physical and emotional trauma as precipitating events in fibromyalgia. Associations with health care seeking and disability status but not pain severity. Arthritis Rheum. 1997, 40: 453-460.PubMed
4.
Walker EA, Keegan D, Gardner G, Sullivan M, Bernstein D, Katon WJ: Psychosocial factors in fibromyalgia compared with rheumatoid arthritis: II. Sexual, physical, and emotional abuse and neglect. Psychosom Med. 1997, 59: 572-577.PubMed
5.
Bradley LA, Alarcon GS, Aaron LA, Martin MY, Alberts KR, Sotolongo A: Abnormal pain perception in patients with fibromyalgia: comment on the article by Bendtsen et al. Arthritis Rheum. 1997, 40: 2275-2277.PubMed
6.
Neeck G: Pathogenic mechanisms of fibromyalgia. Ageing Res Rev. 2002, 1: 243-255. 10.1016/S1568-1637(01)00004-6.PubMed
7.
Riedel W, Layka H, Neeck G: Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. Z Rheumatol. 1998, Suppl 2: 81-87. 10.1007/s003930050242.
8.
Russell IJ: Advances in fibromyalgia: possible role for central neurochemicals. Am J Med Sci. 1998, 315: 377-384. 10.1097/00000441-199806000-00006.PubMed
9.
Ladd CO, Huot RL, Thrivikraman KV, Nemeroff CB, Meaney MJ, Plotsky PM: Long-term behavioral and neuroendocrine adaptations to adverse early experience. Prog Brain Res. 2000, 122: 81-103.PubMed
10.
Plotsky PM, Meaney MJ: Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Brain Res Mol Brain Res. 1993, 18: 195-200. 10.1016/0169-328X(93)90189-V.PubMed
11.
Meaney MJ, Diorio J, Francis D, Widdowson J, LaPlante P, Caldji C, Sharma S, Seckl JR, Plotsky PM: Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Dev Neurosci. 1996, 18: 49-72.PubMed
12.
Breier A, Kelsoe JR, Kirwin PD, Beller SA, Wolkowitz OM, Pickar D: Early parental loss and development of adult psychopathology. Arch Gen Psychiatry. 1988, 45: 987-993.PubMed
13.
De Bellis MD, Chrousos GP, Dorn LD, Burke L, Helmers K, Kling MA, Trickett PK, Putnam FW: Hypothalamic–pituitary–adrenal axis dysregulation in sexually abused girls. J Clin Endocrinol Metab. 1994, 78: 249-255. 10.1210/jc.78.2.249.PubMed
14.
Kaufman J, Birmaher B, Perel J, Dahl RE, Moreci P, Nelson B, Wells W, Ryan ND: The corticotropin-releasing hormone challenge in depressed abused, depressed nonabused, and normal control children. Biol Psychiatry. 1997, 42: 669-679. 10.1016/S0006-3223(96)00470-2.PubMed
15.
Clauw DJ, Chrousos GP: Chronic pain and fatigue syndromes: overlapping clinical and neuroendocrine features and potential pathogenic mechanisms. Neuroimmunomodulation. 1997, 4: 134-153.PubMed
16.
McCain GA, Tilbe KS: Diurnal hormone variation in fibromyalgia syndrome: a comparison with rheumatoid arthritis. J Rheumatol Suppl. 1989, 19: 154-157.PubMed
17.
Crofford LJ, Pillemer SR, Kalogeras KT, Cash JM, Michelson D, Kling MA, Sternberg EM, Gold PW, Chrousos GP, Wilder RL: Hypothalamic–pituitary–adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum. 1994, 37: 1583-1592.PubMed
18.
Griep EN, Boersma JW, Lentjes EG, Prins AP, van der Korst JK, de Kloet ER: Function of the hypothalamic–pituitary–adrenal axis in patients with fibromyalgia and low back pain. J Rheumatol. 1998, 25: 1374-1381.PubMed
19.
Griep EN, Boersma JW, de Kloet ER: Altered reactivity of the hypothalamic–pituitary–adrenal axis in the primary fibromyalgia syndrome. J Rheumatol. 1993, 20: 469-474.PubMed
20.
Disdier P, Harle JR, Brue T, Jaquet P, Chambourlier P, Grisoli F, Weiller PJ: Severe fibromyalgia after hypophysectomy for Cushing's disease. Arthritis Rheum. 1991, 34: 493-495.PubMed
21.
Hudson JI, Pliner LF, Hudson MS, Goldenberg DL, Melby JC: The dexamethasone suppression test in fibrositis. Biol Psychiatry. 1984, 19: 1489-1493.PubMed
22.
Ferraccioli G, Cavalieri F, Salaffi F, Fontana S, Scita F, Nolli M, Maestri D: Neuroendocrinologic findings in primary fibromyalgia (soft tissue chronic pain syndrome) and in other chronic rheumatic conditions (rheumatoid arthritis, low back pain). J Rheumatol. 1990, 17: 869-873.PubMed
23.
Deuschle M, Schweiger U, Weber B, Gotthardt U, Korner A, Schmider J, Standhardt H, Lammers CH, Heuser I: Diurnal activity and pulsatility of the hypothalamus–pituitary–adrenal system in male depressed patients and healthy controls. J Clin Endocrinol Metab. 1997, 82: 234-238. 10.1210/jc.82.1.234.PubMed
24.
Plotsky PM, Owens MJ, Nemeroff CB: Psychoneuroendocrinology of depression. Hypothalamic–pituitary–adrenal axis. Psychiatr Clin North Am. 1998, 21: 293-307.PubMed
25.
Zobel AW, Nickel T, Kunzel HE, Ackl N, Sonntag A, Ising M, Holsboer F: Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J Psychiatr Res. 2000, 34: 171-181. 10.1016/S0022-3956(00)00016-9.PubMed
26.
Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB: The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol. 1999, 160: 1-12. 10.1677/joe.0.1600001.PubMed
27.
Checkley S: The neuroendocrinology of depression and chronic stress. Br Med Bull. 1996, 52: 597-617.PubMed
28.
Deuschle M, Weber B, Colla M, Depner M, Heuser I: Effects of major depression, aging and gender upon calculated diurnal free plasma cortisol concentrations: a re-evaluation study. Stress. 1998, 2: 281-287.PubMed
29.
Maestu J, Jurimae J, Jurimae T: Hormonal reactions during heavy training stress and following tapering in highly trained male rowers. Horm Metab Res. 2003, 35: 109-113. 10.1055/s-2003-39053.PubMed
30.
Roth-Isigkeit A, Brechmann J, Dibbelt L, Sievers HH, Raasch W, Schmucker P: Persistent endocrine stress response in patients undergoing cardiac surgery. J Endocrinol Invest. 1998, 21: 12-19.PubMed
31.
Chatterton RT, Vogelsong KM, Lu YC, Hudgens GA: Hormonal responses to psychological stress in men preparing for skydiving. J Clin Endocrinol Metab. 1997, 82: 2503-2509. 10.1210/jc.82.8.2503.PubMed
32.
Farrace S, Biselli R, Urbani L, Ferlini C, De Angelis C: Evaluation of stress induced by flight activity by measuring the hormonal response. Biofeedback Self Regul. 1996, 21: 217-228.PubMed
33.
Blizzard RM, Bulatovic A: Psychosocial short stature: a syndrome with many variables. Baillieres Clin Endocrinol Metab. 1992, 6: 687-712. 10.1016/S0950-351X(05)80119-3.PubMed
34.
Powell GF, Brasel JA, Raiti S, Blizzard RM: Emotional deprivation and growth retardation simulating idiopathic hypopituitarism. II. Endocrinologic evaluation of the syndrome. N Engl J Med. 1967, 276: 1279-1283.PubMed
35.
Skuse D, Albanese A, Stanhope R, Gilmour J, Voss L: A new stress-related syndrome of growth failure and hyperphagia in children, associated with reversibility of growth-hormone insufficiency. Lancet. 1996, 348: 353-358. 10.1016/S0140-6736(96)01358-X.PubMed
36.
Bennett RM, Cook DM, Clark SR, Burckhardt CS, Campbell SM: Hypothalamic–pituitary–insulin-like growth factor-I axis dysfunction in patients with fibromyalgia. J Rheumatol. 1997, 24: 1384-1389.PubMed
37.
Bennett RM, Clark SR, Campbell SM, Burckhardt CS: Low levels of somatomedin C in patients with the fibromyalgia syndrome. A possible link between sleep and muscle pain. Arthritis Rheum. 1992, 35: 1113-1116.PubMed
38.
Griep EN, Boersma JW, de Kloet ER: Pituitary release of growth hormone and prolactin in the primary fibromyalgia syndrome. J Rheumatol. 1994, 21: 2125-2130.PubMed
39.
Ferraccioli G, Guerra P, Rizzi V, Baraldo M, Salaffi F, Furlanut M, Bartoli E: Somatomedin C (insulin-like growth factor 1) levels decrease during acute changes of stress related hormones. Relevance for fibromyalgia. J Rheumatol. 1994, 21: 1332-1334.PubMed
40.
Leal-Cerro A, Povedano J, Astorga R, Gonzalez M, Silva H, Garcia-Pesquera F, Casanueva FF, Dieguez C: The growth hormone (GH)–releasing hormone–GH–insulin-like growth factor-1 axis in patients with fibromyalgia syndrome. J Clin Endocrinol Metab. 1999, 84: 3378-3381. 10.1210/jc.84.9.3378.PubMed
41.
Bennett RM: Beyond fibromyalgia: ideas on etiology and treatment. J Rheumatol Suppl. 1989, 19: 185-191.PubMed
42.
Wallymahmed ME, Baker GA, Humphris G, Dewey M, MacFarlane IA: The development, reliability and validity of a disease specific quality of life model for adults with growth hormone deficiency. Clin Endocrinol (Oxf). 1996, 44: 403-411. 10.1046/j.1365-2265.1996.704523.x.
43.
Cuneo RC, Salomon F, McGauley GA, Sonksen PH: The growth hormone deficiency syndrome in adults. Clin Endocrinol (Oxf). 1992, 37: 387-397.
44.
Cuneo RC, Salomon F, Wiles CM, Hesp R, Sonksen PH: Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. J Appl Physiol. 1991, 70: 695-700.PubMed
45.
Rutherford OM, Beshyah SA, Schott J, Watkins Y, Johnston DG: Contractile properties of the quadriceps muscle in growth hormone-deficient hypopituitary adults. Clin Sci (Lond). 1995, 88: 67-71.
46.
McGauley GA, Cuneo RC, Salomon F, Sonksen PH: Psychological well-being before and after growth hormone treatment in adults with growth hormone deficiency. Horm Res. 1990, Suppl 4: 52-54.
47.
Salomon F, Cuneo RC, Hesp R, Sonksen PH: The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med. 1989, 321: 1797-1803.PubMed
48.
Florini JR: Hormonal control of muscle growth. Muscle Nerve. 1987, 10: 577-598. 10.1002/mus.880100702.PubMed
49.
Bennett RM, Clark SC, Walczyk J: A randomized, double-blind, placebo-controlled study of growth hormone in the treatment of fibromyalgia. Am J Med. 1998, 104: 227-231. 10.1016/S0002-9343(97)00351-3.PubMed
50.
Dessein PH, Shipton EA, Joffe BI, Hadebe DP, Stanwix AE, Van der Merwe BA: Hyposecretion of adrenal androgens and the relation of serum adrenal steroids, serotonin and insulin-like growth factor-1 to clinical features in women with fibromyalgia. Pain. 1999, 83: 313-319. 10.1016/S0304-3959(99)00113-X.PubMed
51.
Masi AT, Chrousos GP: Hypothalamic–pituitary–adrenal–glucocorticoid axis function in rheumatoid arthritis. J Rheumatol. 1996, 23: 577-581.PubMed
52.
Labbate LA, Fava M, Oleshansky M, Zoltec J, Littman A, Harig P: Physical fitness and perceived stress. Relationships with coronary artery disease risk factors. Psychosomatics. 1995, 36: 555-560.PubMed
53.
Blauer KL, Poth M, Rogers WM, Bernton EW: Dehydroepiandrosterone antagonizes the suppressive effects of dexamethasone on lymphocyte proliferation. Endocrinology. 1991, 129: 3174-3179.PubMed
54.
Goodyer IM, Herbert J, Altham PM, Pearson J, Secher SM, Shiers HM: Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation. Psychol Med. 1996, 26: 245-256.PubMed
55.
Zumoff B, Walsh BT, Katz JL, Levin J, Rosenfeld RS, Kream J, Weiner H: Subnormal plasma dehydroisoandrosterone to cortisol ratio in anorexia nervosa: a second hormonal parameter of ontogenic regression. J Clin Endocrinol Metab. 1983, 56: 668-672.PubMed
56.
Morgan CA, Wang S, Mason J, Southwick SM, Fox P, Hazlett G, Charney DS, Greenfield G: Hormone profiles in humans experiencing military survival training. Biol Psychiatry. 2000, 47: 891-901. 10.1016/S0006-3223(99)00307-8.PubMed
57.
Friedl KE, Moore RJ, Hoyt RW, Marchitelli LJ, Martinez-Lopez LE, Askew EW: Endocrine markers of semistarvation in healthy lean men in a multistressor environment. J Appl Physiol. 2000, 88: 1820-1830.PubMed
58.
Opstad PK: Androgenic hormones during prolonged physical stress, sleep, and energy deficiency. J Clin Endocrinol Metab. 1992, 74: 1176-1183. 10.1210/jc.74.5.1176.PubMed
59.
60.
Bagatell CJ, Bremner WJ: Androgens in men – uses and abuses. N Engl J Med. 1996, 334: 707-714. 10.1056/NEJM199603143341107.PubMed
61.
Liu JH: Hypothalamic amenorrhea: clinical perspectives, pathophysiology, and management. Am J Obstet Gynecol. 1990, 163: 1732-1736.PubMed
62.
Kaplan JR, Adams MR, Clarkson TB, Manuck SB, Shively CA, Williams JK: Psychosocial factors, sex differences, and atherosclerosis: lessons from animal models. Psychosom Med. 1996, 58: 598-611.PubMed
63.
Ballinger S: Stress as a factor in lowered estrogen levels in the early postmenopause. Ann NY Acad Sci. 1990, 592: 95-113.PubMed
64.
Komesaroff PA, Esler MD, Sudhir K: Estrogen supplementation attenuates glucocorticoid and catecholamine responses to mental stress in perimenopausal women. J Clin Endocrinol Metab. 1999, 84: 606-610. 10.1210/jc.84.2.606.PubMed
65.
Sita A, Miller SB: Estradiol, progesterone and cardiovascular response to stress. Psychoneuroendocrinology. 1996, 21: 339-346. 10.1016/0306-4530(95)00053-4.PubMed
66.
Anderberg UM: Comment on: Johns and Littlejohn, The role of sex hormones in pain response. Pain. 2000, 87: 109-111. 10.1016/S0304-3959(00)00268-2.PubMed
67.
Ostensen M, Rugelsjoen A, Wigers SH: The effect of reproductive events and alterations of sex hormone levels on the symptoms of fibromyalgia. Scand J Rheumatol. 1997, 26: 355-360.PubMed
68.
Waxman J, Zatzkis SM: Fibromyalgia and menopause. Examination of the relationship. Postgrad Med. 1986, 80: 165-171.PubMed
69.
Macfarlane TV, Blinkhorn A, Worthington HV, Davies RM, Macfarlane GJ: Sex hormonal factors and chronic widespread pain: a population study among women. Rheumatology. 2002, 41: 454-457. 10.1093/rheumatology/41.4.454.PubMed
70.
Van Vollenhoven RF, McGuire JL: Estrogen, progesterone, and testosterone: can they be used to treat autoimmune diseases?. Cleve Clin J Med. 1994, 61: 276-284.PubMed
71.
Aloisi AM: Gonadal hormones and sex differences in pain reactivity. Clin J Pain. 2003, 19: 168-174. 10.1097/00002508-200305000-00004.PubMed
72.
Akkus S, Delibas N, Tamer MN: Do sex hormones play a role in fibromyalgia?. Rheumatology. 2000, 39: 1161-1163. 10.1093/rheumatology/39.10.1161.PubMed
73.
Marcus DA: Interrelationships of neurochemicals, estrogen, and recurring headache. Pain. 1995, 62: 129-139. 10.1016/0304-3959(95)00052-T.PubMed
74.
Mense S: Neurobiological concepts of fibromyalgia – the possible role of descending spinal tracts. Scand J Rheumatol Suppl. 2000, 113: 24-29. 10.1080/030097400446599.PubMed
75.
Russell IJ: Fibromyalgia syndrome: approaches to management. Bull Rheum Dis. 1996, 45: 1-4.PubMed
76.
Rueter LE, Fornal CA, Jacobs BL: A critical review of 5-HT brain microdialysis and behavior. Rev Neurosci. 1997, 8: 117-137.PubMed
77.
Chaouloff F: Physiopharmacological interactions between stress hormones and central serotonergic systems. Brain Res Brain Res Rev. 1993, 18: 1-32. 10.1016/0165-0173(93)90005-K.PubMed
78.
Weiss JM, Goodman PA, Losito BG, Corrigan S, Charry JM, Bailey WB: Behavioral depression produced by an uncontrollable stressor: relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain. Brain Res Rev. 1981, 3: 167-205. 10.1016/0165-0173(81)90005-9.
79.
Sherman AD, Petty F: Neurochemical basis of the action of antidepressants on learned helplessness. Behav Neural Biol. 1980, 30: 119-134. 10.1016/S0163-1047(80)91005-5.PubMed
80.
De Souza EB, Van Loon GR: Brain serotonin and catecholamine responses to repeated stress in rats. Brain Res. 1986, 367: 77-86. 10.1016/0006-8993(86)91581-7.PubMed
81.
McKittrick CR, Blanchard DC, Blanchard RJ, McEwen BS, Sakai RR: Serotonin receptor binding in a colony model of chronic social stress. Biol Psychiatry. 1995, 37: 383-393. 10.1016/0006-3223(94)00152-S.PubMed
82.
Moldofsky H: Rheumatic pain modulation syndrome: the interrelationships between sleep, central nervous system serotonin, and pain. Adv Neurol. 1982, 33: 51-57.PubMed
83.
Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Javors MA, Bowden CA: Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol. 1992, 19: 104-109.PubMed
84.
Stratz T, Samborski W, Hrycaj P, Pap T, Mackiewicz S, Mennet P, Muller W: Serotonin concentration in serum of patients with generalized tendomyopathy (fibromyalgia) and chronic polyarthritis. Med Klin. 1993, 88: 458-462.
85.
Bradley LA, Alberts KR, Alarcon GS, Alexander MT, Mountz JM, Weigent DA, Lin HG, Blalock JE, Aaron LA, Alexander RW, San Pedro EC, Martin MY, Morell AC: Abnormal brain regional cerebral blood flow (rCBF) and cerebrospinal fluid (CSF) levels of substance P (SP) in patients and non-patients with fibromyalgia (FM) [abstract]. Arthritis Rheum. 1996, Suppl 9: 212-
86.
Hrycaj P, Stratz T, Muller W: Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol. 1993, 20: 1986-1988.PubMed
87.
Wolfe F, Russell IJ, Vipraio G, Ross K, Anderson J: Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population. J Rheumatol. 1997, 24: 555-559.PubMed
88.
Russell IJ, Vipraio GA, Acworth I: Abnormalities in the central nervous system (CNS) metabolism of tryptophan (TRY) to 3-hydroxykynurenine (OHKY) in fibromyalgia syndrome (FS) [abstract]. Arthritis Rheum. 1993, Suppl 9: 222-
89.
Risch SC, Nemeroff CB: Neurochemical alterations of serotonergic neuronal systems in depression. J Clin Psychiatry. 1992, Suppl 53: 3-7.
90.
Grahame-Smith DG: Serotonin in affective disorders. Int Clin Psychopharmacol. 1992, Suppl 4: 5-13.
91.
Aaron LA, Bradley LA, Alarcon GS, Alexander RW, Triana-Alexander M, Martin MY, Martin MY, Alberts KR: Psychiatric diagnoses in patients with fibromyalgia are related to health care-seeking behavior rather than to illness. Arthritis Rheum. 1996, 39: 436-445.PubMed
92.
Bradley LA: Behavioral interventions for managing chronic pain. Bull Rheum Dis. 1994, 43: 2-5.PubMed
93.
Malmberg AB, Yaksh TL: Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science. 1992, 257: 1276-1279.PubMed
94.
Mantyh PW, Hunt SP, Maggio JE: Substance P receptors: localization by light microscopic autoradiography in rat brain using [3H]SP as the radioligand. Brain Res. 1984, 307: 147-165. 10.1016/0006-8993(84)90470-0.PubMed
95.
Lisoprawski A, Blanc G, Glowinski J: Activation by stress of the habenulo-interpeduncular substance P neurons in the rat. Neurosci Lett. 1981, 25: 47-51. 10.1016/0304-3940(81)90099-9.PubMed
96.
Brent PJ, Johnston PA, Chahl LA: Increased plasma catecholamines and locomotor activity induced by centrally administered substance P in guinea-pigs. Neuropharmacology. 1988, 27: 743-748. 10.1016/0028-3908(88)90084-6.PubMed
97.
Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scollnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Rupniak NM: Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science. 1998, 281: 1640-1645. 10.1126/science.281.5383.1640.PubMed
98.
Miczek KA, Weerts EM, Vivian JA, Barros HM: Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics. Psychopharmacology. 1995, 121: 38-56.PubMed
99.
Vaeroy H, Helle R, Forre O, Kass E, Terenius L: Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis. Pain. 1988, 32: 21-26. 10.1016/0304-3959(88)90019-X.PubMed
100.
Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, Lopez Y, MacKillip F: Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis Rheum. 1994, 37: 1593-1601.PubMed
101.
Welin M, Bragee B, Nyberg F, Kristiansson M: Elevated substance P levels are contrasted by a decrease in metenkephalin-arg-phe levels in csf from fibromyalgia patients [abstract]. J Musculoskeletal Pain. 1995, Suppl 1: 4-
102.
Chiu YH, McBeth J, Silman AJ, Ray D, Macfarlane GJ: A population based study of chronic widespread pain and the hypothalamic–pituitary–adrenal (HPA) axis: results from a pilot study [abstract]. Rheumatology. 2002, Suppl 1: 52-
Metadaten
Titel
Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link
verfasst von
Anindya Gupta
Alan J Silman
Publikationsdatum
01.06.2004
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 3/2004
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1176

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Immer mehr jüngere Menschen leiden unter Vorhofflimmern. Betroffene unter 65 Jahren haben viele Risikofaktoren und ein signifikant erhöhtes Sterberisiko verglichen mit Gleichaltrigen ohne die Erkrankung.

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