Introduction
Materials and methods
Participants
Antibody measurement and genotyping
Statistical analyses
Results
Characteristics of the study population
Antibody status |
n
| Larsen's score (mean ± SEM) |
P
|
---|---|---|---|
RF positive | 552 | 49.1 ± 1.7 | <0.0001a |
RF negative | 268 | 33.0 ± 1.9 | |
Anti-CCP positive | 672 | 46.9 ± 1.5 | <0.0001a |
Anti-CCP negative | 159 | 31.3 ± 2.4 | |
RF positive/CCP positive | 493 | 49.6 ± 1.8 | <0.0001b |
RF positive/CCP negative | 39 | 37.6 ± 5.2 | |
RF negative/CCP positive | 143 | 37.2 ± 2.7 | |
RF negative/CCP negative | 109 | 28.0 ± 2.8 |
Antibody status | Number of SE alleles |
n
| Larsen's score (mean ± SEM) | P (SE2 versus SE1 versus SE0) |
---|---|---|---|---|
All | 2 | 266 | 46.5 ± 2.3 | NS |
1 | 393 | 43.6 ± 1.9 | ||
0 | 168 | 39.2 ± 2.6 | ||
RF positive | 2 | 177 | 49.5 ± 2.9 | NS |
1 | 253 | 49.4 ± 2.5 | ||
0 | 94 | 47.0 ± 3.7 | ||
RF negative | 2 | 71 | 39.0 ± 4.3 | 0.0458a |
1 | 120 | 32.3 ± 2.7 | ||
0 | 65 | 25.9 ± 3.1 | ||
CCP positive | 2 | 226 | 49.1 ± 2.5 | NS |
1 | 312 | 45.7 ± 2.1 | ||
0 | 98 | 44.3 ± 3.4 | ||
CCP negative | 2 | 30 | 32.0 ± 5.9 | NS |
1 | 67 | 32.3 ± 3.7 | ||
0 | 58 | 29.2 ± 3.9 |
RF status | Number of SE alleles | Proportion anti-CCP positive | OR (95% CI) |
P
|
---|---|---|---|---|
All | 2 | 214/241 | 4.94 (2.94–8.22) | <0.001 |
1 | 307/373 | 2.90 (1.89–4.43) | ||
0 | 98/159 | 1 | ||
RF positive | 2 | 162/170 | 4.15 (1.79–9.58) | <0.01 |
1 | 236/253 | 2.85 (1.41–5.77) | ||
0 | 78/94 | 1 | ||
RF negative | 2 | 52/71 | 6.16 (3.00–12.6) | <0.001 |
1 | 71/120 | 3.26 (1.74–6.11) | ||
0 | 20/65 | 1 |