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Breast Cancer Research
Erschienen in: Breast Cancer Research 5/2007

01.10.2007 | Commentary

Clinical trials update: endocrine and biological therapy combinations in the treatment of breast cancer

verfasst von: Alexandra F Leary, Bhawna Sirohi, Stephen RD Johnston

Erschienen in: Breast Cancer Research | Ausgabe 5/2007

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Abstract

A greater understanding of the biological mechanisms responsible for de novo and acquired endocrine resistance has led to the rational design of clinical trials exploring the benefit of combining hormonal therapies with novel biological agents in an effort to enhance the efficacy of ER+ breast cancer treatment. These studies are increasingly including parallel biological analyses to elucidate the molecular characteristics of those tumors that are most likely to respond to specific targeted/endocrine combinations in an effort to develop a tailored approach to the management of individual patients. Unfortunately despite encouraging preclinical data, some of these combinations have yielded disappointing results in the clinical setting. This article will review the results of clinical trials of endocrine/biological combinations conducted in early and advanced breast cancer as well as provide an update on ongoing studies.
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Metadaten
Titel
Clinical trials update: endocrine and biological therapy combinations in the treatment of breast cancer
verfasst von
Alexandra F Leary
Bhawna Sirohi
Stephen RD Johnston
Publikationsdatum
01.10.2007
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 5/2007
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1763

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