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Breast Cancer Research
Erschienen in: Breast Cancer Research 6/2009

01.12.2009 | Review

Epithelial to mesenchymal transition and breast cancer

verfasst von: Eva Tomaskovic-Crook, Erik W Thompson, Jean Paul Thiery

Erschienen in: Breast Cancer Research | Ausgabe 6/2009

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Abstract

Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy. The transcriptional and epigenetic regulation of molecular and cellular processes that underlie breast cancer and result in characteristic changes in cell behavior can be monitored using an increasing array of marker proteins. Amongst these markers exists the potential for emergent prognostic, predictive and therapeutic targeting.
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Metadaten
Titel
Epithelial to mesenchymal transition and breast cancer
verfasst von
Eva Tomaskovic-Crook
Erik W Thompson
Jean Paul Thiery
Publikationsdatum
01.12.2009
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 6/2009
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2416

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