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Erschienen in: Breast Cancer Research 2/2012

01.04.2012 | Viewpoint

PTHrP and breast cancer: more than hypercalcemia and bone metastases

verfasst von: Kata Boras-Granic, John J Wysolmerski

Erschienen in: Breast Cancer Research | Ausgabe 2/2012

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Abstract

Parathyroid hormone-related protein (PTHrP) causes hypercalcemia in cancer patients. PTHrP is required for normal breast development and has been shown to promote bone metastases from breast cancers. However, whether the protein also contributes to the formation of primary tumors has been unclear. Two recent papers suggest it may. First, a report in Nature Genetics identified the PTHrP locus as a new breast cancer susceptibility gene. Second, a paper in Journal of Clinical Investigation demonstrated that PTHrP promotes tumor growth and metastases in MMTV-PyMT mice. These studies implicate PTHrP in the development and growth of primary breast tumors and underscore the need for further research.
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Metadaten
Titel
PTHrP and breast cancer: more than hypercalcemia and bone metastases
verfasst von
Kata Boras-Granic
John J Wysolmerski
Publikationsdatum
01.04.2012
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 2/2012
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3129

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