Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Breast Cancer Research
Erschienen in: Breast Cancer Research 1/1999

01.12.1999 | Commentary

Endogenous hormones and the aetiology of breast cancer

verfasst von: Timothy J Key, Pia K Verkasalo

Erschienen in: Breast Cancer Research | Ausgabe 1/1999

Einloggen, um Zugang zu erhalten

Excerpt

After several decades of epidemiological and laboratory research, how well do we understand the role of endogenous hormones in the aetiology of breast cancer? Early studies showed that risk varies with several hormonal events: risk is increased by early menarche and late menopause, and decreased by giving birth at a young age and by high parity. The protective effect of pregnancy is probably due to hormonally induced differentiation of breast epithelial cells, causing a reduction in the number of susceptible cells. The effects of age at menarche and menopause indicate that the duration of exposure to cyclic ovarian function is an important determinant of breast cancer risk, but it has proved difficult to establish whether oestradiol and/or progesterone is responsible, or to show whether variations in hormone levels between women have any important effect on risk. …
Literatur
1.
Garland CF, Friedlander NJ, Barrett-Connor E, Khaw K-T: Sex hormones and postmenopausal breast cancer: a prospective study in an adult community. Am J Epidemiol. 1992, 135: 1220-1230.PubMed
2.
Helzlsouer KJ, Alberg AJ, Bush TL, Longcope C, Gordon GB, Comstock GW: A prospective study of endogenous hormones and breast cancer. Cancer Detect Prev. 1994, 18: 79-85.PubMed
3.
Toniolo PG, Levitz M, Zeleniuch-Jacquotte A, et al: A prospective study of endogenous estrogens and breast cancer in postmenopausal women. J Natl Cancer Inst. 1995, 87: 190-197. 10.1093/jnci/87.3.190.CrossRefPubMed
4.
Berrino F, Muti P, Micheli A, et al: Serum sex hormone levels after menopause and subsequent breast cancer. J Natl Cancer Inst. 1996, 88: 291-296.CrossRefPubMed
5.
Dorgan JF, Longcope C, Stephenson HE, et al: Relation of prediagnostic serum estrogen and androgen levels to breast cancer risk. Cancer Epidemiol, Biomarkers & Prev. 1996, 5: 533-539.
6.
Thomas HV, Key TJ, Allen DS, et al: A prospective study of endogenous serum hormone concentrations and breast cancer risk in postmenopausal women on the island of Guernsey. Br J Cancer. 1997, 76: 401-405.CrossRefPubMedPubMedCentral
7.
Hankinson SE, Willett WC, Manson JE, et al: Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 1998, 90: 1292-1299. 10.1093/jnci/90.17.1292.CrossRefPubMed
8.
Cauley JA, Lucas FL, Kuller LH, et al: Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Ann Intern Med. 1999, 130: 270-277.CrossRefPubMed
9.
Wysowski DK, Comstock GW, Helsing KJ, Lau HL: Sex hormone levels in serum in relation to the development of breast cancer. Am J Epidemiol. 1987, 125: 791-799.PubMed
10.
Rosenberg CR, Pasternack BS, Shore RE, Koenig KL, Toniolo PG: Premenopausal estradiol levels and the risk of breast cancer: a new method of controlling for day of the menstrual cycle. Am J Epidemiol. 1994, 140: 518-525.PubMed
11.
Thomas HV, Key TJ, Allen DS, et al: A prospective study of endogenous serum hormone concentrations and breast cancer risk in premenopausal women on the island of Guernsey. Br J Cancer. 1997, 75: 1075-1079.CrossRefPubMedPubMedCentral
12.
Muti P, Trevisan M, Micheli A, et al: Reliability of serum hormones in premenopausal and postmenopausal women over a one-year period. Cancer Epidemiol Biomarkers Prev. 1996, 5: 917-922.PubMed
13.
Cummings SR, Eckert S, Krueger KA, et al: The effect of raloxifene on risk of breast cancer in postmenopausal women. J Am Med Ass. 1999, 281: 2189-2197. 10.1001/jama.281.23.2189.CrossRef
14.
Dorgan JF, Stanczyk FZ, Longcope C, et al: Relationship of serum dehydroepiandrosterone [DHEA], DHEA sulfate, and 5-androstene-3β, 17β-diol to risk of breast cancer in postmenopausal women. Cancer Epidemiol Biomarkers Prev . 1997, 6: 177-181.PubMed
15.
Gordon GB, Bush TL, Helzlsouer KJ, Miller SR, Comstock GW: Relationship of serum levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate to the risk of developing postmenopausal breast cancer. Cancer Res. 1990, 50: 3859-3862.PubMed
16.
Zeleniuch-Jacquotte A, Bruning PF, Bonfrer JMG, et al: Relation of serum levels of testosterone and dehydroepiandrosterone sulfate to risk of breast cancer in postmenopausal women. Am J Epidemiol. 1997, 145: 1030-1038.CrossRefPubMed
17.
Hankinson SE, Manson JE, Spiegelman D, et al: Reproducibility of serum hormone levels in postmenopausal women over a 2-3-year period. Cancer Epidemiol Biomarkers Prev. 1995, 4: 649-654.PubMed
18.
Hankinson SE, Willett WC, Colditz GA, et al: Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet. 1998, 351: 1393-1396. 10.1016/S0140-6736(97)10384-1.CrossRefPubMed
19.
Hankinson SE, Willett WC, Michaud DS: Plasma prolactin levels and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 1999, 91: 629-634. 10.1093/jnci/91.7.629.CrossRefPubMed
20.
Preston-Martin S, Pike MC, Ross RK, Jones PA, Henderson BE: Increased cell division as a cause of human cancer. Cancer Res. 1990, 50: 7415-7421.PubMed
21.
Anderson TJ, Ferguson DJP, Raab GM: Cell turnover in the 'resting' human breast: influence of parity, contraceptive pill, age and laterality. Br J Cancer. 1982, 46: 376-382.CrossRefPubMedPubMedCentral
22.
McManus MJ, Welsch CW: The effect of estrogen, progesterone, thyroxine, and human placental lactogen on DNA synthesis of human breast ductal epithelium maintained in athymic nude mice. Cancer. 1984, 54: 1920-1927.CrossRefPubMed
23.
Laidlaw IJ, Clarke RB, Howell A, et al: The proliferation of normal human breast tissue implanted into athymic nude mice is stimulated by estrogen but not progesterone. Endocrinology . 1995, 136: 164-171. 10.1210/en.136.1.164.PubMed
24.
Pike MC, Ursin G, Spicer DV: Experiments on proliferation of normal human breast tissue in nude mice do not show that progesterone does not stimulate breast cells [Letter]. Endocrinology. 1996, 137: 1505-1506. 10.1210/en.137.4.1505.PubMed
25.
Yager JD, Liehr JG: Molecular mechanisms of estrogen carcinogenesis. Ann Rev Pharmacol Toxicol. 1996, 36: 203-232. 10.1146/annurev.pa.36.040196.001223.CrossRef
26.
Cavalieri EL, Stack DE, Devanesan PD, et al: Molecular origin of cancer: catechol estrogen-3, 4-quinones as endogenous tumor initiators. Proc Natl Acad Sci USA. 1997, 94: 10937-10942. 10.1073/pnas.94.20.10937.CrossRefPubMedPubMedCentral
27.
Millikan RC, Pittman GS, Tse C-KJ, et al: Catechol-0-methyltransferase and breast cancer risk. Carcinogenesis. 1998, 19: 1943-1947. 10.1093/carcin/19.11.1943.CrossRefPubMed
28.
Fan S, Wang J-A, Yuan R, et al: BRCA1 inhibition of estrogen receptor signaling in transfected cells. Science. 1999, 284: 1354-1356. 10.1126/science.284.5418.1354.CrossRefPubMed
29.
Ahlbom A, Lichtenstein P, Malmström H, et al: Cancer in twins: genetic and nongenetic familial risk factors. J Natl Cancer Inst. 1997, 89: 287-293. 10.1093/jnci/89.4.287.CrossRefPubMed
30.
Verkasalo PK, Kaprio J, Koskenvuo M, Pukkala E: Genetic predisposition, environment and cancer incidence: a nationwide twin study in Finland, 1976-95. Int J Cancer. 1999,
31.
Feigelson HS, Shames LS, Pike MC, Coetzee GA, Stanczyk FZ, Henderson BE: Cytochrome P450c17α gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations. Cancer Res. 1998, 58: 585-587.PubMed
32.
Haiman CA, Hankinson SE, Spiegelman D, et al: The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer. Cancer Res. 1999, 59: 1015-1020.PubMed
33.
Feigelson HS, Coetzee GA, Kolonel LN, Ross RK, Henderson BE: A polymorphism in the CYP17 gene increases the risk of breast cancer. Cancer Res. 1997, 57: 1063-1065.PubMed
34.
Dunning AM, Healey CS, Pharoah PDP: No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer. Br J Cancer. 1998, 77: 2045-2047.CrossRefPubMedPubMedCentral
35.
Helzlsouer KJ, Huang H-Y, Strickland PT: Association between CYP17 polymorphisms and the development of breast cancer. Cancer Epidemiol, Biomarkers Prev. 1998, 7: 945-949.
36.
Weston A, Pan C-f, Bleiweiss IJ, et al: CYP17 genotype and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 1998, 7: 941-944.PubMed
37.
Siiteri PK, MacDonald PC: Role of extraglandular estrogen in human endocrinology. Handbook of physiology. 1973, 615-629.
38.
La Vecchia C, Negri E, Franceschi S, et al: Body mass index and postmenopausal breast cancer: an age-specific analysis. Br J Cancer. 1997, 75: 441-444.CrossRefPubMedPubMedCentral
39.
Bernstein L, Henderson BE, Hanisch R, Sullivan-Halley J, Ross RK: Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst. 1994, 86: 1403-1408. 10.1093/jnci/86.18.1403.CrossRefPubMed
40.
Smith-Warner SA, Spiegelman D, Yaun S-S, et al: Alcohol and breast cancer in women. A pooled analysis of cohort studies. JAMA. 1998, 279: 535-540. 10.1001/jama.279.7.535.CrossRefPubMed
41.
Muti P, Trevisan M, Micheli A, et al: Alcohol consumption and total estradiol in premenopausal women. Cancer Epidemiol Biomarkers Prev. 1998, 7: 189-193.PubMed
42.
Ziegler RG, Hoover RN, Pike MC, et al: Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst. 1993, 85: 1819-1827.CrossRefPubMed
43.
Probst-Hensch NM, Pike MC, McKean-Cowdin R, Stanczyk FZ, Kolonel LN, Henderson BE: Ethnic differences in postmenopausal plasma estrogen levels high estrone levels in Japanese-American women despite low weight. Br J Cancer. 1999,
Metadaten
Titel
Endogenous hormones and the aetiology of breast cancer
verfasst von
Timothy J Key
Pia K Verkasalo
Publikationsdatum
01.12.1999
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 1/1999
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr7

Weitere Artikel der Ausgabe 1/1999

Breast Cancer Research 1/1999 Zur Ausgabe

Paper Report

Extracellular matrix modulates mammary gland growth factor signalling

Paper Report

Proliferation markers in preinvasive breast lesions

Paper Report

Raloxifene and breast cancer risk

Paper Report

Adenoviral topoisomerase II αgene transfer increases sensitivity of resistant cancer cells

Paper Report

Heregulin signalling through HER-2 leads to increased epithelial cell growth

Paper Report

bcl-2 and tamoxifen-induced apoptosis

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

23.04.2024 Medikamente in Schwangerschaft und Stillzeit Nachrichten

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise