Background
Methods
Study design
Microbiological investigations
Statistical methods
Ethics and consent
Results
Serotype | Percent of isolates, children | Percent of isolates, adults | P value | Percent of isolates, overall | No of isolates, overall |
---|---|---|---|---|---|
14
| 23.7 | 7.9 |
<0.0001
| 17.5 | 232 |
19F
| 9.3 | 6.0 | 0.0260 | 8.2 | 108 |
6B
| 9.1 | 5.1 | 0.0050 | 7.7 | 102 |
18C
| 8.5 | 2.8 |
<0.0001
| 6.3 | 83 |
23F
| 6.8 | 8.9 | 0.1562 | 8.1 | 107 |
7F
| 6.3 | 4.6 | 0.1945 | 5.8 | 77 |
6A
| 4.4 | 5.5 | 0.3783 | 5.1 | 67 |
4
| 3.5 | 7.1 | 0.0028 | 5.3 | 70 |
1
| 2.8 | 1.7 | 0.2063 | 2.4 | 32 |
19A
| 2.4 | 3.0 | 0.6153 | 2.8 | 37 |
3
| 1.9 | 7.1 |
<0.0001
| 4.4 | 58 |
10A
| 1.8 | 3.6 | 0.0406 | 2.7 | 36 |
9V
| 1.7 | 5.6 |
0.0001
| 3.6 | 47 |
8
| 1.3 | 3.1 | 0.0221 | 2.2 | 29 |
33F
| 1.0 | 1.7 | 0.3452 | 1.4 | 18 |
11A
| 0.9 | 2.1 | 0.0686 | 1.5 | 20 |
15B
| 0.9 | 1.0 | 1.0000 | 1.0 | 13 |
9N
| 0.8 | 2.3 | 0.0220 | 1.5 | 20 |
22F
| 0.6 | 3.5 |
0.0002
| 2.0 | 26 |
15C
| 0.6 | 0.3 | 0.4771 | 0.5 | 7 |
23A
| 0.5 | 1.7 | 0.0547 | 1.1 | 14 |
6C
| 0.5 | 0.5 | 1.0000 | 0.5 | 7 |
5
| 0.5 | 0.2 | 0.3934 | 0.4 | 5 |
12F
| 0.4 | 1.7 | 0.0220 | 1.0 | 13 |
17F
| 0.4 | 1.0 | 0.1912 | 0.7 | 9 |
23B
| 0.3 | 0.5 | 0.6588 | 0.4 | 5 |
20
| 0.3 | 0.3 | 1.0000 | 0.3 | 4 |
2
| 0.1 | 0.3 | 0.5845 | 0.2 | 3 |
35B
| 0.1 | 0.0 | 1.0000 | 0.1 | 1 |
others
| 8.5 | 10.9 | 0.1402 | 10.0 | 132 |
Serotype | Percent of isolates, children | Percent of isolates, adults | P value | Percent of isolates, overall | No of isolates, overall |
---|---|---|---|---|---|
7F
| 8.8 | 9.1 | 1.0000 | 8.8 | 56 |
19A
| 7.2 | 6.6 | 0.7289 | 6.6 | 42 |
10A
| 7.2 | 4.0 | 0.0737 | 4.9 | 31 |
23B
| 7.2 | 9.6 | 0.4467 | 8.6 | 55 |
12F
| 6.2 | 5.9 | 0.8541 | 5.8 | 37 |
3
| 5.7 | 9.4 | 0.2035 | 8.0 | 51 |
15C
| 5.7 | 2.8 | 0.1029 | 3.6 | 23 |
22F
| 4.1 | 5.9 | 0.5604 | 5.2 | 33 |
35B
| 4.1 | 1.2 | 0.0273 | 2.0 | 13 |
19F
| 2.6 | 3.3 | 0.8044 | 3.0 | 19 |
11A
| 2.6 | 4.0 | 0.4894 | 3.4 | 22 |
33F
| 2.6 | 1.9 | 0.5481 | 2.0 | 13 |
6B
| 2.1 | 0.7 | 0.2081 | 1.1 | 7 |
8
| 2.1 | 3.3 | 0.6054 | 2.8 | 18 |
15B
| 2.1 | 3.0 | 0.7897 | 2.7 | 17 |
9N
| 1.5 | 3.0 | 0.4139 | 2.5 | 16 |
6C
| 1.5 | 2.1 | 1.0000 | 1.9 | 12 |
23A
| 1.5 | 4.2 | 0.1462 | 3.3 | 21 |
18C
| 1.0 | 2.1 | 0.5180 | 1.7 | 11 |
23F
| 0.5 | 1.2 | 0.6731 | 0.9 | 6 |
1
| 0.5 | 2.1 | 0.2966 | 1.6 | 10 |
5
| 0.5 | 0.0 | 0.3041 | 0.2 | 1 |
6A
| 0.5 | 1.9 | 0.2892 | 1.4 | 9 |
4
| 0.0 | 0.7 | 0.5571 | 0.5 | 3 |
9V
| 0.0 | 0.5 | 1.0000 | 0.3 | 2 |
14
| 0.0 | 1.9 | 0.1140 | 1.3 | 8 |
2
| 0.0 | 0.0 | 1.0000 | 0.0 | 0 |
17F
| 0.0 | 0.7 | 0.5571 | 0.5 | 3 |
20
| 0.0 | 0.9 | 0.3197 | 0.6 | 4 |
others
| 22.2 | 12.2 |
0.0010
| 14.9 | 95 |
Serotype | Percent of isolates, children | Percent of isolates, adults | P value | Percent of isolates, overall | No of isolates, overall |
---|---|---|---|---|---|
7F
| 16.7 | 6.9 |
0.0001
| 9.6 | 74 |
18C
| 7.9 | 2.5 |
0.0011
| 4.0 | 31 |
1
| 7.0 | 2.9 | 0.0149 | 4.0 | 31 |
14
| 4.8 | 2.7 | 0.1817 | 3.3 | 25 |
3
| 4.8 | 12.8 |
0.0007
| 10.2 | 78 |
6A
| 4.8 | 5.4 | 0.8593 | 5.1 | 39 |
6B
| 4.4 | 1.1 | 0.0100 | 2.1 | 16 |
22F
| 4.4 | 6.3 | 0.3927 | 5.6 | 43 |
19A
| 4.0 | 5.0 | 0.7066 | 4.6 | 35 |
15C
| 4.0 | 1.3 | 0.0288 | 2.1 | 16 |
10A
| 3.5 | 5.0 | 0.4487 | 4.4 | 34 |
19F
| 2.2 | 4.8 | 0.1081 | 3.9 | 30 |
23F
| 2.2 | 3.4 | 0.4908 | 3.0 | 23 |
8
| 2.2 | 2.7 | 0.8052 | 2.5 | 19 |
12F
| 2.2 | 2.7 | 0.8052 | 2.5 | 19 |
15B
| 1.8 | 3.1 | 0.4595 | 2.6 | 20 |
23A
| 1.8 | 2.9 | 0.4569 | 2.5 | 19 |
9N
| 1.3 | 2.9 | 0.2992 | 2.3 | 18 |
17F
| 1.3 | 0.6 | 0.3740 | 0.8 | 6 |
33F
| 1.3 | 1.9 | 0.7640 | 1.7 | 13 |
9V
| 0.9 | 2.3 | 0.2484 | 1.8 | 14 |
6C
| 0.9 | 2.9 | 0.1126 | 2.2 | 17 |
35B
| 0.9 | 1.3 | 0.7305 | 1.2 | 9 |
4
| 0.4 | 2.3 | 0.1232 | 1.7 | 13 |
11A
| 0.4 | 2.1 | 0.1196 | 1.6 | 12 |
23B
| 0.4 | 2.1 | 0.1196 | 1.6 | 12 |
5
| 0.0 | 0.2 | 1.0000 | 0.1 | 1 |
2
| 0.0 | 0.0 | 1.0000 | 0.0 | 0 |
20
| 0.0 | 0.6 | 0.5575 | 0.4 | 3 |
others
| 13.2 | 9.6 | 0.1564 | 10.4 | 80 |
Children | 1992/93-2005/06 | 2007/08-2009/10 | 2010/11-2012/13 | P values | |||||
---|---|---|---|---|---|---|---|---|---|
Serotypes | (n) | % | (n) | % | (n) | % | Pre PCV 7 vs post PCV7+13 | Pre PCV7 vs post PCV7 | Post PCV7 vs post PCV13 |
4
| 27 | 3.5 | 1 | 0.4 | 0 | 0.0 |
0.0002↓
| 0.0105↓ | 1.0000 |
6B
| 71 | 9.1 | 10 | 4.4 | 4 | 2.1 |
0.0001↓
| 0.0188↓ | 0.2755↓ |
9V
| 13 | 1.7 | 2 | 0.9 | 0 | 0.0 | 0.1015↓ | 0.5414↓ | 0.5019↓ |
14
| 184 | 23.7 | 11 | 4.8 | 0 | 0.0 |
<0.0001↓
|
<0.0001↓
| 0.0012↓ |
18C
| 66 | 8.5 | 18 | 7.9 | 2 | 1.0 | 0.0186↓ | 0.8918↓ | 0.0008↓ |
19F
| 72 | 9.3 | 5 | 2.2 | 5 | 2.6 |
<0.0001↓
|
0.0002↓
| 1.0000 |
23F
| 53 | 6.8 | 5 | 2.2 | 1 | 0.5 |
<0.0001↓
| 0.0088↓ | 0.2241↓ |
PCV 7
| 486 | 62.5 | 52 | 22.9 | 12 | 6.2 |
<0.0001↓
|
<0.0001↓
|
<0.0001↓
|
1
| 22 | 2.8 | 16 | 7.0 | 1 | 0.5 | 0.3062↑ | 0.0087↑ |
0.0007↓
|
5
| 4 | 0.5 | 0 | 0.0 | 1 | 0.5 | 0.6624↓ | 0.5799↓ | 0.4608↑ |
7F
| 49 | 6.3 | 38 | 16.7 | 17 | 8.8 |
0.0001↑
|
<0.0001↑
| 0.0197↓ |
PCV10
| 561 | 72.2 | 106 | 46.7 | 31 | 16.0 |
<0.0001↓
|
<0.0001↓
|
<0.0001↓
|
3
| 15 | 1.9 | 11 | 4.8 | 11 | 5.7 | 0.0025↑ | 0.0287↑ | 0.8269↑ |
6A
| 34 | 4.4 | 11 | 4.8 | 1 | 0.5 | 0.2106↑ | 0.7184↑ | 0.0074↓ |
19A
| 19 | 2.4 | 9 | 4.0 | 14 | 7.2 | 0.0084↑ | 0.2504↑ | 0.1961↑ |
PCV13
| 629 | 81.0 | 137 | 60.4 | 57 | 29.4 |
<0.0001↓
|
<0.0001↓
|
<0.0001↓
|
2
| 1 | 0.1 | 0 | 0.0 | 0 | 0.0 | 1.0000 | 1.0000 | 1.0000 |
8
| 10 | 1.3 | 5 | 2.2 | 4 | 2.1 | 0.3323↑ | 0.3497↑ | 1.0000 |
9N
| 6 | 0.8 | 3 | 1.3 | 3 | 1.5 | 0.3624↑ | 0.4309↑ | 1.0000 |
10A
| 14 | 1.8 | 8 | 3.5 | 14 | 7.2 | 0.0021↑ | 0.1255↑ | 0.1230↑ |
11A
| 7 | 0.9 | 1 | 0.4 | 5 | 2.6 | 0.3969↑ | 0.6912↓ | 0.0991↑ |
12F
| 3 | 0.4 | 5 | 2.2 | 12 | 6.2 |
<0.0001↑
| 0.0174↑ | 0.0472↑ |
15B
| 7 | 0.9 | 4 | 1.8 | 4 | 2.1 | 0.1734↑ | 0.2811↑ | 1.0000 |
17F
| 3 | 0.4 | 3 | 1.3 | 0 | 0.0 | 0.4295↑ | 0.1329↑ | 0.2528↓ |
20
| 2 | 0.3 | 0 | 0.0 | 0 | 0.0 | 0.5438↓ | 1.0000 | 1.0000 |
22F
| 5 | 0.6 | 10 | 4.4 | 8 | 4.1 |
<0.0001↑
|
0.0003↑
| 1.0000 |
33F
| 8 | 1.0 | 3 | 1.3 | 5 | 2.6 | 0.2906↑ | 0.7189↑ | 0.4793↑ |
PPV23
| 729 | 93.8 | 199 | 87.7 | 137 | 70.6 |
<0.0001↓
| 0.6504↓ |
<0.0001↓
|
6C
| 4 | 0.5 | 2 | 0.9 | 3 | 1.5 | 0.2917↑ | 0.6226↑ | 0.6653↑ |
15C
| 5 | 0.6 | 9 | 4.0 | 11 | 5.7 |
<0.0001↑
| 0.0009↑ | 0.4930↑ |
23A
| 4 | 0.5 | 4 | 1.8 | 3 | 1.5 | 0.0588↑ | 0.0826↑ | 1.0000 |
23B
| 2 | 0.3 | 1 | 0.4 | 14 | 7.2 |
<0.0001↑
| 0.5369↑ |
0.0002↑
|
35B
| 1 | 0.1 | 2 | 0.9 | 8 | 4.1 |
0.0002↑
| 0.1300↑ | 0.0492↑ |
others
| 66 | 8.5 | 30 | 13.2 | 43 | 22.2 |
<0.0001↑
| 0.0388↑ | 0.0201↑ |
NVT
| 82 | 10.6 | 48 | 21.1 | 82 | 42.3 |
<0.0001↑
|
0.0001↑
|
<0.0001↑
|
Adults | 1992/93-2005/06 | 2007/08-2009/10 | 2010/11-2012/13 | P values | |||||
---|---|---|---|---|---|---|---|---|---|
Serotypes | (n) | % | (n) | % | (n) | % | pre PCV7 vs post PCV7+13 | pre PCV7 vs post PCV7 | post PCV7 vs post PCV13 |
4
| 43 | 7.1 | 12 | 2.3 | 3 | 0.7 |
<0.0001↓
|
0.0001↓
| 0.0644↓ |
6B
| 31 | 5.1 | 6 | 1.1 | 3 | 0.7 |
<0.0001↓
|
0.0002↓
| 0.5189↓ |
9V
| 34 | 5.6 | 12 | 2.3 | 2 | 0.5 |
<0.0001↓
| 0.0060↓ | 0.0270↓ |
14
| 48 | 7.9 | 14 | 2.7 | 8 | 1.9 |
<0.0001↓
| 0.0001↓ | 0.3952↓ |
18C
| 17 | 2.8 | 13 | 2.5 | 9 | 2.1 | 0.5094↓ | 0.8533↓ | 0.6715↓ |
19F
| 36 | 6.0 | 25 | 4.8 | 14 | 3.3 | 0.0892↓ | 0.4295↓ | 0.2510↓ |
23F
| 54 | 8.9 | 18 | 3.4 | 5 | 1.2 |
<0.0001↓
|
0.0001↓
| 0.0198↓ |
PCV 7
| 263 | 43.5 | 100 | 19.1 | 44 | 9.9 |
<0.0001↓
|
<0.0001↓
|
0.0001↓
|
1
| 10 | 1.7 | 15 | 2.9 | 9 | 2.1 | 0.2918↑ | 0.2232↑ | 0.5347↓ |
5
| 1 | 0.2 | 1 | 0.2 | 0 | 0.0 | 1.0000 | 1.0000 | 1.0000 |
7F
| 28 | 4.6 | 36 | 6.9 | 39 | 9.1 | 0.0158↑ | 0.1212↑ | 0.2799↑ |
PCV10
| 302 | 49.9 | 152 | 29.1 | 92 | 9.4 |
<0.0001↓
|
<0.0001↓
| 0.0030↓ |
3
| 43 | 7.1 | 67 | 12.8 | 40 | 9.4 | 0.0103↑ | 0.0017↑ | 0.0645↓ |
6A
| 33 | 5.5 | 28 | 5.4 | 8 | 1.9 | 0.1283↓ | 1.0000 | 0.0035↓ |
19A
| 18 | 3.0 | 26 | 5.0 | 28 | 6.6 | 0.0180↑ | 0.0912↑ | 0.4007↑ |
PCV13
| 396 | 65.5 | 273 | 52.2 | 168 | 17.2 |
<0.0001↓
|
<0.0001↓
|
<0.0001↓
|
2
| 2 | 0.3 | 0 | 0.0 | 0 | 0.0 | 0.1480↓ | 0.5022↓ | 1.0000 |
8
| 19 | 3.1 | 14 | 2.7 | 14 | 3.3 | 0.7636↓ | 0.7246↓ | 0.7032↑ |
9N
| 14 | 2.3 | 15 | 2.9 | 13 | 3.0 | 0.5245↑ | 0.5768↑ | 1.0000 |
10A
| 22 | 3.6 | 26 | 5.0 | 17 | 4.0 | 0.5154↑ | 0.3016↑ | 0.4360↓ |
11A
| 13 | 2.1 | 11 | 2.1 | 17 | 4.0 | 0.4186↓ | 1.0000 | 0.1256↑ |
12F
| 10 | 1.7 | 14 | 2.7 | 25 | 5.9 | 0.0072↑ | 0.3013↑ | 0.0219↑ |
15B
| 6 | 1.0 | 16 | 3.1 | 13 | 3.0 | 0.0080↑ | 0.0161↑ | 1.0000 |
17F
| 6 | 1.0 | 3 | 0.6 | 3 | 0.7 | 0.5530↓ | 0.5165↓ | 1.0000 |
20
| 2 | 0.3 | 3 | 0.6 | 4 | 0.9 | 0.4958↑ | 0.6677↑ | 0.7091↑ |
22F
| 21 | 3.5 | 33 | 6.3 | 25 | 5.9 | 0.0321↑ | 0.0351↑ | 0.6856↓ |
33F
| 10 | 1.7 | 10 | 1.9 | 8 | 1.9 | 0.8463↑ | 0.8227↑ | 1.0000 |
PPV23
| 488 | 80.7 | 511 | 97.7 | 375 | 68 |
<0.0001↑
| 0.0146↑ | 0.0153↓ |
6C
| 3 | 0.5 | 15 | 2.9 | 9 | 2.1 | 0.0023↑ | 0.0016↑ | 0.5347↓ |
15C
| 2 | 0.3 | 7 | 1.3 | 12 | 2.8 | 0.0055↑ | 0.0900↑ | 0.1634↑ |
23A
| 10 | 1.7 | 15 | 2.9 | 18 | 4.2 | 0.0392↑ | 0.2232↑ | 0.3749↑ |
23B
| 3 | 0.5 | 11 | 2.1 | 41 | 9.6 |
<0.0001↑
| 0.0272↑ |
<0.0001
|
35B
| 0 | 0.0 | 7 | 1.3 | 5 | 1.2 | 0.0048↑ | 0.0045↑ | 1.0000 |
others
| 66 | 10.9 | 50 | 9.6 | 52 | 12.2 | 0.8668↓ | 0.4921↓ | 0.2945↑ |
NVT
| 84 | 13.9 | 105 | 20.1 | 137 | 32.1 |
<0.0001↑
| 0.0065↑ |
0.0001↑
|
Children <16 years | Adults ≥16 years | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Year | 7v | 10v | 13v | 13v non 7v | 23v | 7v | 10v | 13v | 13v non 7v | 23v |
1992-1993 | 52.9 | 52.9 | 82.4 | 29.4 | 64.7 | 43.8 | 56.3 | 64.6 | 20.8 | 81.3 |
1993-1994 | 54.5 | 54.5 | 63.6 | 9.1 | 90.9 | 31.0 | 35.7 | 52.4 | 21.4 | 69.0 |
1994-1995 | 88.9 | 88.9 | 100.0 | 11.1 | 100.0 | 31.3 | 39.6 | 60.4 | 29.2 | 79.2 |
1995-1996 | 75.0 | 75.0 | 75.0 | 0.0 | 87.5 | 41.9 | 51.2 | 67.4 | 25.6 | 93.0 |
1996-1997 | 41.2 | 64.7 | 79.4 | 38.2 | 73.5 | 56.0 | 60.0 | 68.0 | 12.0 | 76.0 |
1997-1998 | 60.6 | 66.7 | 72.7 | 12.1 | 77.3 | 45.0 | 50.0 | 75.0 | 30.0 | 75.0 |
1998-1999 | 64.9 | 73.7 | 84.2 | 19.3 | 93.0 | 48.0 | 52.0 | 72.0 | 24.0 | 80.0 |
1999-2000 | 75.0 | 83.9 | 87.5 | 12.5 | 89.3 | 57.1 | 64.3 | 78.6 | 21.4 | 96.4 |
2000-2001 | 62.3 | 71.0 | 78.3 | 15.9 | 81.2 | 51.4 | 57.1 | 68.6 | 17.1 | 85.7 |
2001-2002 | 57.0 | 68.4 | 78.5 | 21.5 | 89.9 | 42.2 | 42.2 | 53.3 | 11.1 | 73.3 |
2002-2003 | 65.3 | 75.0 | 79.2 | 13.9 | 86.1 | 41.1 | 50.0 | 67.9 | 26.8 | 76.8 |
2003-2004 | 64.1 | 73.9 | 84.8 | 20.7 | 84.8 | 44.1 | 49.2 | 61.0 | 16.9 | 78.0 |
2004-2005 | 60.2 | 68.0 | 81.6 | 21.4 | 82.5 | 39.4 | 50.7 | 70.4 | 31.0 | 78.9 |
2005-2006 | 65.4 | 78.8 | 82.7 | 17.3 | 89.4 | 51.7 | 51.7 | 68.3 | 16.7 | 88.3 |
1992/93-2005/06 | 62.5 | 72.2 | 81.0 | 18.4 | 85.1 | 43.5 | 49.9 | 65.5 | 22.0 | 80.7 |
(pre PCV7) | ||||||||||
2006-2007 | 47.1 | 63.6 | 80.2 | 33.1 | 85.1 | 35.0 | 46.9 | 64.4 | 29.4 | 80.6 |
2007-2008 | 33.3 | 52.0 | 65.3 | 32.0 | 76.0 | 21.3 | 34.4 | 51.9 | 30.6 | 79.2 |
2008-2009 | 19.1 | 43.8 | 56.2 | 37.1 | 73.0 | 24.4 | 32.2 | 56.1 | 31.7 | 76.1 |
2009-2010 | 15.9 | 44.4 | 60.3 | 44.4 | 73.0 | 10.6 | 19.4 | 48.1 | 37.5 | 67.5 |
2007/08-2009/10 | 22.9 | 46.7 | 60.4 | 37.4 | 74.0 | 19.1 | 29.1 | 52.2 | 33.1 | 74.6 |
(post PCV7) | ||||||||||
2010-2011 | 11.4 | 21.5 | 40.5 | 29.1 | 55.7 | 13.4 | 25.6 | 49.4 | 36.0 | 74.4 |
2011-2012 | 5.6 | 24.1 | 33.3 | 27.8 | 64.8 | 9.2 | 22.0 | 36.9 | 27.7 | 67.4 |
2012-2013 | 0.0 | 1.6 | 11.5 | 11.5 | 52.5 | 6.5 | 13.7 | 25.2 | 18.7 | 59.0 |
2010/11-2012/13 | 6.2 | 16.0 | 29.4 | 23.2 | 57.2 | 9.9 | 20.7 | 37.8 | 27.9 | 67.3 |
(post PCV13) | ||||||||||
pre7 vs. post7+post13 | <0.0001 | <0.0001 | <0.0001 | 0.0137 | 0.0004 | <0.0001 | <0.0001 | 0.0001 | 0.0140 | 0.0130 |
pre7 vs. post7 | <0.0001 | 0.0010 | 0.0010 | 0.0024 | 0.0539 | 0.0001 | 0.0005 | 0.0065 | 0.0096 | 0.1900 |
post7 vs. post13 | 0.0529 | 0.0148 | 0.0243 | 0.0887 | 0.0129 | 0.1219 | 0.2328 | 0.1130 | 0.3448 | 0.2637 |
Children <16 years | Adults ≥16 years | CLSI breakpoints (mg/L) | ||||||
---|---|---|---|---|---|---|---|---|
I% | R% | n | I% | R% | n | I | R | |
Penicillin G, meningitis | 0.0 | 7.2 | 1,317 | 0.0 | 7.2 | 1,731 | - | ≥0.12 |
Cefotaxime, meningitis | 0.8 | 0.5 | 1,317 | 0.9 | 0.2 | 1,729 | 1 | ≥2 |
Macrolides* | 0.1 | 19.8 | 1,317 | 0.1 | 10.8 | 1,730 | 0.5 | ≥1 |
Clindamycin | 0.2 | 5.9 | 1,316 | 0.5 | 5.7 | 1,730 | 0.5 | ≥1 |
Tetracycline | 0.4 | 9.2 | 1,316 | 0.9 | 8.9 | 1,731 | 2 | ≥4 |
Levofloxacin | 0.2 | 0.3 | 874 | 0.2 | 0.1 | 1,326 | 4 | ≥8 |
SXT | 6.1 | 5.7 | 870 | 7.1 | 5.5 | 1,318 | 1/19-2/38 | ≥4/76 |