Background
Materials and methods
Subjects
Urine sampling
Assessment of urinary steroid hormones by GC-MS
Assessment of urinary creatinine concentrations
Statistics
Results
Participants
Parameter | Bern | Glasgow | Graz |
---|---|---|---|
Maternal Age (yrs) | 31.5 ± 3.8 | 29.6 ± 6.3 | 31.8 ± 5.3 |
Booking BMI (kg/m2) | 25.5 ± 3.8 | 24.3 ± 5.4 | 23.8 ± 3.7 |
Gestational age at delivery (Wks) | 39 ± 1.2 | 40 ± 1.2 | 39 ± 1.3 |
Birthweight (g) | 3505 ± 658 | 3477 ± 530 | 3304 ± 346 |
Baby gender (% male) | 51 | 46 | 40 |
Reference intervals
1st trimester (n = 81) | 2nd trimester (n = 40) | 3rd trimester (n = 40) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Reference intervals | Reference intervals | Reference intervals | ||||||||||
move to a separate row | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] |
Androsterone | 322 ± 196 | 289 | 40.0 [36.0, 91.7] | 764 [740, 780] | 209 ± 172 | 159 | 17.3 [16.6, 55.5] | 746 [665, 748] | 237 ± 274 | 134 | 5.9 [5.5, 38.0] | 1409 [844, 1423] |
Etiocholanolone | 231 ± 141 | 211 | 31.0 [30.9, 65.3] | 617 [542, 688] | 149 ± 95.4 | 126 | 24.0 [23.7, 61.5] | 518 [355, 522] | 163 ± 176 | 108 | 6.5 [6.0, 34.9] | 774 [707, 776] |
11-Oxo-Etiocholanolon | 38.6 ± 18.7 | 37.6 | 6.3 [1.7, 11.5] | 84.4 [74.1, 87.0] | 38.0 ± 19.0 | 35.1 | 6.4 [6.3, 15.3] | 77.8 [72.7, 77.9] | 49.1 ± 52.3 | 36.7 | 5.8 [5.8, 13.5] | 325 [125, 325] |
11β-Hydroxy-Androsterone | 89.8 ± 53.3 | 75.1 | 20.8 [17.1, 23.1] | 233 [212, 234] | 70.8 ± 44.3 | 62.6 | 7.3 [7.1, 21.2] | 192 [188, 193] | 94.3 ± 123 | 58.7 | 4.9 [4.5, 21.4] | 716 [315, 726] |
11β-Hydroxy-Etiocholanolon | 31.5 ± 22.1 | 29.3 | 5.7 [4.8, 8.6] | 83.8 [65.3, 163] | 39.5 ± 28.6 | 28.6 | 3.2 [3.1, 11.6] | 112 [97.7, 112] | 43.4 ± 28.8 | 37.0 | 10.6 [10.5, 12.7] | 141 [105, 141] |
Dehydroepiandrosterone | 86.2 ± 158 | 23.1 | 1.5 [1.5, 4.4] | 759 [569, 774] | 49.6 ± 87.5 | 18.4 | 0.7 [0.7, 2.1] | 380 [348, 380] | 61.6 ± 167 | 12.0 | 1.3 [1.3, 2.5] | 919 [520, 929] |
5-Androstene-3β,17β-diol | 26.8 ± 25.6 | 18.8 | 1.4 [0.9, 4.1] | 125 [78.0, 144] | 20.1 ± 16.1 | 16.0 | 0.9 [0.9, 5.1] | 85.3 [55.2, 86] | 25.5 ± 29.8 | 17.9 | 1.0 [1.0, 5.5] | 175 [69.0, 175] |
5-Androstene-3β,17β-triol | 17.3 ± 57.2 | 5.3 | 0.7 [0.7, 1.8] | 225 [92.6, 454] | 10.9 ± 33.0 | 2.6 | 0.8 [0.8, 1.0] | 164 [139, 165] | 9.9 ± 20.8 | 2.6 | 0.7 [0.7, 0.9] | 115 [51.5, 115] |
16α-Hydroxy-dehydroepiandrostrerone | 96.4 ± 101 | 60.7 | 2.9 [1.2, 14.4] | 415 [277, 600] | 107 ± 107 | 88.7 | 2.1 [2.0, 12.5] | 569 [259, 577] | 154 ± 340 | 77.5 | 3.4 [3.3, 13.0] | 2139 [376, 2139] |
5-Androstene-3β,16α,17β-triol | 84.3 ± 75.0 | 55.8 | 9.2 [7.5, 22.2] | 278 [209, 306] | 65.4 ± 60.0 | 52.8 | 11.7 [11.7, 27.7] | 313 [127, 317] | 107 ± 155 | 60.2 | 12.4 [12.3, 18.5] | 868 [454, 868] |
5-Pregnene-3β,16α,17,20α-triol | 48.2 ± 56.5 | 36.8 | 1.2 [0.9, 3.5] | 317 [161, 397] | 20.6 ± 25.5 | 13.6 | 0.9 [0.9, 2.1] | 151 [50.7, 154] | 38.1 ± 111 | 11.4 | 1.7 [1.7, 2.9] | 690 [107, 690] |
Testosterone | 2.0 ± 1.8 | 1.6 | 0.3 [0.2, 0.5] | 9.4 [6, 11.1] | 2.4 ± 3.2 | 1.3 | 0.3 [0.3, 0.4] | 18.5 [7.4, 18.8] | 3.6 ± 5.6 | 2.0 | 0.5 [0.5, 0.7] | 27.8 [27.8, 28.1] |
5α-Dihydrotestosterone | 4.6 ± 3.2 | 3.6 | 0.6 [0.5, 1.1] | 12.3 [11.4, 12.9] | 3.7 ± 2.6 | 3.2 | 0.5 [0.5, 1.2] | 11.1 [10.1, 11.1] | 5.7 ± 3.7 | 4.6 | 0.4 [0.4, 1.7] | 19.1 [11.3, 19.3] |
1st trimester (n = 81) | 2nd trimester (n = 40) | 3rd trimester (n = 40) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Reference intervals | Reference intervals | Reference intervals | ||||||||||
move to a separate row | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] |
Estriol | 135 ± 151 | 79.9 | 10.6 [3.5, 17.0] | 545 [489, 901] | 975 ± 584 | 836 | 143 [143, 2881] | 2877 [2660, 2881] | 2651 ± 2651 | 1955 | 636 [636, 764] | 15192 [9171, 15116] |
17β-Estradiol | 9.1 ± 6.7 | 7.3 | 0.7 [0.6, 2.1] | 26.4 [24.8, 28.8] | 16.6 ± 12.0 | 14.5 | 1.8 [1.8, 4.6] | 63.5 [45.0, 64.0] | 25.2 ± 25.2 | 24.0 | 2.3 [2.3, 8.9] | 117 [111, 117] |
Progesterone metabolites | ||||||||||||
Pregnenolone | 14.2 ± 10.0 | 12.5 | 2.8 [2.6, 4.2] | 53.0 [41.3, 54] | 18.0 ± 14.7 | 14.9 | 1.9 [1.9, 3.3] | 65.3 [57.3, 65.5] | 27.9 ± 42.4 | 16.9 | 4.2 [4.2, 6.2] | 265 [94.2, 265] |
17-Hydroxypregnanolone | 91.0 ± 76.4 | 79.5 | 14.6 [9.1, 23.1] | 229 [202, 599] | 88.3 ± 55.5 | 72.8 | 18.8 [18.7, 41.9] | 247 [238, 247] | 189 ± 253 | 113 | 34.1 [34.2, 50.6] | 1298 1051, 1298] |
Pregnanediol | 1269 ± 830 | 1110 | 215 [154, 416] | 4257 [3093, 4405] | 1765 ± 1291 | 1461 | 459 [457, 633] | 7514 [4181, 7602] | 3982 ± 3762 | 2877 | 785 [779, 1162] | 21112 [11216, 21112] |
Pregnanetriol | 209 ± 114 | 191 | 53.9 [34.2, 80.9] | 455 [378, 774] | 182 ± 94.0 | 153 | 35.8 [34.6, 99.6] | 480 [443, 481] | 287 ± 321 | 191 | 53.9 [53.4, 89.2] | 1865 [970, 1865] |
11-Oxopregnanetriol | 2.7 ± 2.7 | 2.0 | 0.4 [0.3, 0.7] | 11.8 [10.5, 14.7] | 2.8 ± 4.4 | 1.5 | 0.3 [0.3, 0.7] | 26.4 [10.0, 26.9] | 11.3 ± 29.2 | 1.9 | 0.2 [0.2, 0.5] | 151 [99.2, 1501] |
1st trimester (n = 81) | 2nd trimester (n = 40) | 3rd trimester (n = 40) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Reference intervals | Reference intervals | Reference intervals | ||||||||||
move to a separate row | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] |
Tetrahydro-11-deoxycortisol | 17.1 ± 10.1 | 15.5 | 2.7 [1.2, 6.9] | 43.1 [35.1, 62.5] | 23.2 ± 11.5 | 21.2 | 5.2 [5.1, 11.3] | 56.2 [51.9, 56.3] | 37.1 ± 27.4 | 31.6 | 8.9 [8.9, 11.4] | 146 [110, 147] |
Tetrahydro-11-deoxycorticosterone | 12.5 ± 8.8 | 10.2 | 1.7 [0.9, 3.8] | 40.1 [33.9, 46.6] | 35.3 ± 102 | 16.1 | 4.1 [4.1, 5.9] | 643 [466, 629] | 588 ± 1681 | 31.6 | 6.1 [6.1, 14.7] | 8789 [5075, 8875] |
Corticosterone metabolites | ||||||||||||
Tetrahydroaldosterone | 15.4 ± 10.7 | 12.0 | 2.7 [2.1, 5.0] | 49.8 [36.5, 65.6] | 18.2 ± 19.5 | 11.4 | 1.6 [1.6, 3.9] | 114 [40.6, 116] | 22.9 ± 16.6 | 18.2 | 2.1 [2.1, 7.1] | 87.1 [55.1, 87.9] |
Tetrahydro-11-dehydrocorticosterone | 33.6 ± 23.7 | 26.7 | 3.9 [3.2, 10.9] | 108 [88.5, 130] | 35.1 ± 19.3 | 30.3 | 10.2 [10.1, 15.8] | 89.4 [87.1, 89.4] | 88.0 ± 88.9 | 56.1 | 13.4 [13.3, 27.4] | 385 [371, 386] |
Tetrahydrocorticosterone | 23.1 ± 12.7 | 21.4 | 3.4 [3.0, 8.1] | 57.8 [48.5, 63.4] | 25.8 ± 13.2 | 22.3 | 3.3 [3.2, 8.5] | 57.9 [55.0, 58.0] | 83.0 ± 107.3 | 43.4 | 15.2 [15.1, 22.5] | 586 [344, 591] |
5α-Tetrahydro-corticosterone | 51.5 ± 39.3 | 39.8 | 5.9 [4.3, 13.9] | 189 [143, 194] | 33.8 ± 21.6 | 30.0 | 1.7 [1.6, 9.8] | 93.0 [91.7, 93] | 59.0 ± 62.4 | 33.8 | 5.6 [5.6, 15.0] | 304 [241, 306] |
1st trimester (n = 81) | 2nd trimester (n = 40) | 3rd trimester (n = 40) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Reference intervals | Reference intervals | Reference intervals | ||||||||||
move to a separate row | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] |
Cortisone | 34.6 ± 25.2 | 28.4 | 4.7 [4.4, 10.2] | 110 [97.7, 113] | 64.5 ± 39.8 | 53.3 | 14.1 [14.0, 25.8] | 165 [161, 165] | 79.1 ± 43.0 | 82.3 | 4.8 [4.7, 22.6] | 180 [144, 181] |
Tetrahydrocortisone | 368 ± 165 | 349 | 77.6 [73.4, 162] | 780 [644, 624] | 308 ± 190 | 255 | 73.8 [73.4, 90.5] | 948 [926, 947] | 321 ± 210 | 267 | 5.9 [4.7, 101] | 923 [748, 922] |
α-Cortolon | 227 ± 170 | 211 | 27.6 [17.7, 35.8] | 715 [641, 725] | 112 ± 138 | 75.9 | 15.7 [15.7, 26.0] | 826 [583, 825] | 148 ± 196 | 68.7 | 17.5 [17.5, 22.5] | 752 [741, 752] |
β-Cortolon | 47.9 ± 37.9 | 43.4 | 2.5 [1.5, 5.1] | 141 [122, 167] | 27.5 ± 36.5 | 13.3 | 3.8 [3.8, 4.8] | 179 [148, 178] | 35.0 ± 55.1 | 11.2 | 3.6 [3.5, 7.5] | 303 [122, 308] |
Cortisone | 34.6 ± 25.2 | 28.4 | 4.7 [4.4, 10.2] | 110 [97.7, 113] | 64.5 ± 39.8 | 53.3 | 14.1 [14.0, 25.8] | 165 [161, 165] | 79.1 ± 43.0 | 82.3 | 4.8 [4.7, 22.6] | 180 [144, 181] |
20α-Dihydrocortisone | 5.4 ± 3.2 | 4.3 | 1.5 [1.4, 2.2] | 14.9 [12.9, 15.2] | 8.2 ± 3.8 | 7.2 | 2.4 [2.4, 4.2] | 15.0 [14.3, 15.0] | 9.8 ± 4.7 | 9.4 | 1.4 [1.4, 4.3] | 19.1 [18.9, 19.1] |
20β-Dihydrocortisone | 22.2 ± 11.9 | 21.2 | 4.2 [3.7, 8.2] | 52.7 [49.9, 54.2] | 34.0 ± 16.5 | 35.3 | 5.7 [5.6, 12.6] | 70.0 [67.4, 70.0] | 45.8 ± 26.9 | 37.7 | 1.8 [1.7, 14.2] | 109 [104, 109] |
Cortisol metabolites | ||||||||||||
Cortisol | 29.1 ± 23.4 | 20 | 4.7 [1.5, 7.6] | 102 [83.7, 119] | 52.3 ± 42.3 | 38.8 | 7.9 [7.8, 17.3] | 210 [168, 210] | 98.2 ± 109 | 69.6 | 2.7 [2.5, 24.5] | 641 [285, 650] |
Tetrahydrocortisol | 191 ± 99.6 | 178 | 26.2 [22.2, 73.1] | 405 [389, 519] | 136 ± 68.1 | 131 | 31.4 [31.2, 58.8] | 296 [277, 296] | 182 ± 202 | 123 | 15.7 [15.6, 52.9] | 923 [823, 926] |
5α-Tetrahydrocortisol | 126 ± 111 | 90.0 | 13.2 [9.6, 27.8] | 412 [379, 538] | 54.7 ± 42.2 | 54.7 | 4.6 [4.6, 18.4] | 158 [157, 158] | 46.7 ± 55.2 | 29.2 | 1.3 [1.2, 10.3] | 258 [218, 259] |
α-Cortol | 55.5 ± 32.0 | 49.9 | 8.9 [8.2, 18.5] | 145 [111, 192] | 37.4 ± 17.9 | 34.6 | 7.1 [6.9, 18.6] | 107 [73.5, 108] | 51.1 ± 56.5 | 35.1 | 6.0 [5.9, 12] | 248 [235, 248] |
β-Cortol | 45.6 ± 22.8 | 39.9 | 14.9 [11.8, 21.0] | 118 [10.0, 122] | 32.4 ± 16.7 | 26.6 | 6.9 [6.7, 15.2] | 80.0 [68.2, 80.3] | 36.3 ± 33.5 | 24.1 | 6.3 [6.2, 13.2] | 187 [101, 189] |
20α-Dihydrocortisol | 30.0 ± 33.7 | 19.7 | 1.9 [1.8, 6.6] | 180 [117, 215] | 60.4 ± 60.2 | 37.3 | 1.7 [1.6, 9.5] | 258 [246, 258] | 145 ± 203 | 74.8 | 5.1 [4.9, 18.3] | 1049 [623, 1060] |
6 weeks postpartum (n = 40) | ||||
---|---|---|---|---|
Steroid μg per mmol creatinine | Reference intervals | |||
move to a separate row | Mean ± SD | Median | 2.5th percentile [90 % CI] | 97.5th percentile [90 % CI] |
Androsterone | 130 ± 116 | 99.8 | 6.5 [6.2, 24.2] | 524 [482, 525] |
Etiocholanolone | 180 ± 120 | 149 | 19.4 [19.3, 42.7] | 456 [423, 457] |
11-Oxo-Etiocholanolone | 51.0 ± 35.1 | 42.1 | 8.0 [8.0, 14.9] | 156 [149, 156] |
11β-Hydroxy-Androsterone | 77.5 ± 51.4 | 71.1 | 4.4 [4.2, 19.1] | 262 [149, 156] |
11β-Hydroxy-Etiocholanolone | 46.4 ± 36.6 | 38.3 | 4.8 [4.8, 9.3] | 161 [150, 161] |
Dehydroepiandrosterone | 33.5 ± 57.1 | 10.4 | 0.8 [0.8, 2.7] | 291 [160, 294] |
5-Androstene-3β,17β-diol | 14.2 ± 15.1 | 9.4 | 0.4 [0.4, 1.6] | 68.0 [50.0, 68.4] |
5-Androstene-3β,17β-triol | 9.8 ± 21.5 | 3.1 | 0.2 [0.2, 0.6] | 113 [76.5, 114] |
16α-Hydroxy-dehydroepiandrostrerone | 46.8 ± 86.8 | 22.8 | 0.9 [0.9, 3.1] | 502 [212, 510] |
5-Androstene-3β,16α,17β-triol | 40.4 ± 45.9 | 29.6 | 3.7 [3.6, 9.5] | 271 [116, 275] |
5-Pregnene-3β,16α,17,20α-triol | 13.5 ± 12.5 | 10.7 | 0.4 [0.4, 1.3] | 59.5 [38.9, 60.0] |
Testosterone | 3.7 ± 5.7 | 1.4 | 0.1 [0.1, 0.5] | 26.0 [22.9, 26.1] |
5α-Dihydrotestosterone | 2.5 ± 2.3 | 2.2 | 0.1 [0.1, 0.6] | 12.4 [8.2, 12.3] |
Oestrogen metabolites | ||||
Estriol | 119 ± 339 | 17.6 | 0.9 [0.9, 1.4] | 2011 [557, 2049] |
17β-Estradiol | 2.9 ± 9.6 | 0.5 | 0.1 [0.05, 0.1] | 58.7 [9.0, 60.0] |
Progesterone precursor and metabolites | ||||
Pregnenolone | 9.8 ± 13.4 | 4.7 | 0.2 [0.2, 0.7] | 52.5 [49.7, 52.2] |
17-Hydroxypregnanolone | 20.2 ± 41.4 | 9.9 | 0.9 [0.9, 2.4] | 257 [76.6, 262] |
Pregnanediol | 257 ± 668 | 76.2 | 10.4 [10.3, 29.5] | 4052 [1173, 4126] |
Pregnanetriol | 56.0 ± 49.7 | 44.3 | 5.9 [5.7, 20.8] | 297 [144, 301] |
11-Oxo-Pregnanetriol | 2.8 ± 3.4 | 1.6 | 0.4 [0.4, 0.7] | 17.7 [10.1, 17.8] |
11-Deoxysteroid metabolites | ||||
Tetrahydro-11-deoxycortisol | 11.1 ± 8.6 | 9.8 | 0.7 [0.7, 3.0] | 43.1 [30.6, 42.8] |
Tetrahydro-11-deoxycorticosterone | 28.2 ± 160 | 1.3 | 0.1 [0.1, 0.4] | 989 [27.0, 1014] |
Corticosterone metabolites | ||||
Tetrahydroaldosterone | 4.2 ± 4.6 | 2.6 | 0.5 [0.5, 1.1] | 21.9 [19.3, 21.9] |
Tetrahydro-11-dehydrocorticosterone | 20.7 ± 23.5 | 14.6 | 0.4 [0.4, 3.3] | 139 [53.9, 142] |
Tetrahydrocorticosterone | 23.8 ± 16.7 | 20.1 | 2.2 [2.2, 6.8] | 71.3 [69.3, 71.3] |
5a-Tetrahydrocorticosterone | 35.7 ± 28.1 | 28.8 | 1.7 [1.6, 6.3] | 143 [113, 143] |
Cortisone metabolite | ||||
Cortisone | 28.2 ± 20.1 | 23.4 | 1.0 [1.0, 10.3] | 101 [74.8, 101] |
Tetrahydrocortisone | 397 ± 233 | 373 | 58.8 [58.2, 120] | 1034 [906, 1037] |
α-Cortolon | 122 ± 117 | 90.5 | 18.1 [18, 33.5] | 707 [286, 718] |
β-Cortolon | 30.6 ± 40.4 | 6.1 | 0.2 [0.2, 1.5] | 156 [141, 155] |
20α-Dihydrocortisone | 3.4 ± 2.7 | 2.7 | 0.2 [0.2, 1.1] | 13.5 [9.7, 13.6] |
20β-Dihydrocortisone | 9.2 ± 6.9 | 8.1 | 0.5 [0.4. 3.1] | 34.3 [24.5, 34.5] |
Cortisol metabolites | ||||
Cortisol | 20.8 ± 19.1 | 13.8 | 0.9 [0.8, 4.1] | 99.7 [66.7, 99.7] |
Tetrahydrocortisol | 256 ± 153 | 243 | 30.7 [30.3, 80.3] | 723 [599, 726] |
5α-Tetrahydrocortisol | 97.1 ± 81.2 | 78.3 | 5.8 [5.4, 22.7] | 381 [302, 383] |
α-Cortol | 41.1 ± 32.6 | 35.5 | 3.9 [3.8, 17.7] | 203 [98.2, 206] |
β-Cortol | 55.3 ± 29.2 | 50.1 | 10.0 [9.9, 25.8] | 130 [114, 130] |
20α-Dihydrocortisol | 17.3 ± 22.6 | 9.3 | 0.2 [0.2, 3] | 127 [50.7, 127] |
6β-Hydroxycortisol | 149 ± 25.8 | 26.5 | 0.9 [0.9, 8.1] | 149 [77.9, 149] |
18-Hydroxycortisol | 322 ± 55.1 | 41.7 | 1.5 [1.4, 4.9] | 322 [130, 322] |
Androgen metabolites
Oestrogen metabolites
Progesterone precursor and metabolites
11-deoxysteroid hormone metabolites
Corticosterone metabolites
Cortisol and cortisone metabolites
Discussion
Full trivial name | Reference | Analyzed enzyme system |
---|---|---|
Androgen metabolites | ||
Androsterone | Androstenedione, testosterone, 5α-dihydrotestosterone, dehydroepiandrosterone | CYP17A1, POR, SRD5A2, HSD17B3 |
Etiocholanolone | Testosterone, dehydroepiandrosterone | CYP17A1, POR, SRD5A2, HSD17B3 |
11β-Hydroxy-androsterone | 11β-hydroxy-androstenedione, cortisol | |
Dehydroepiandrosterone | Dehydroepiandrosterone | HSD3B2 |
5-Androstene-3β,17β-diol | Testosterone, dehydroepiandrosterone | |
5-Androstene-3β,17β-triol | Testosterone, dehydroepiandrosterone | |
16α-Hydroxy-dehydroepiandrosterone | Dehydroepiandrosterone | |
5-Androstene-3β,16α,17β-triol | Testosterone, dehydroepiandrosterone | |
11β-Hydroxy-etiocholanolone | Testosterone, dehydroepiandrosterone, cortisol | |
11-Oxo-etiocholanolone | Testosterone, dehydroepiandrosterone, cortisol | |
Testosterone | Testosterone | |
5α-Dihydrotestosterone | Testosterone | |
Oestrogen metabolites | ||
Estriol | Estradiol | |
17β-Estradiol | Estradiol | |
Progesterone metabolites | ||
Pregnenolone | Pregnenolone | |
17-Hydroxypregnanolone | 17-Hydroxy-progesterone | CYP17A1, POR |
Pregnanediol | Pregnenolone | POR |
Pregnanetriol | 17-Hydroxy-progesterone | CYP21A2, POR |
11-Oxopregnanetriol | 17-Hydroxy-progesterone | CYP21A2 |
5-Pregnene-3β,16α,17,20α-triol | 17-Hydroxy-pregnenolone | HSD3B2 |
11-Deoxysteroid hormone metabolites | ||
Tetrahydro-11-deoxycortisol | 11-Deoxycortisol | CYP11B1 |
Tetrahydro-11-deoxycorticosterone | Corticosterone | |
Corticosterone metabolites | ||
Tetrahydrocorticosterone | 11-Deoxycorticosterone | CYP17A1, POR, SRD5A2 |
5α-Tetrahydrocorticosterone | 11-Deoxycorticosterone | CYP17A1, POR, SRD5A2 |
Tetrahydro-11-dehydrocorticosterone | Corticosterone | CYP17A1, POR |
Tetrahydroaldosterone | Aldosterone | |
Cortisol metabolites | ||
Cortisol | Cortisol | HSD11B2 |
Tetrahydrocortisol | Cortisol | CYP21A2, CYP11B1, CYP17A1, HSD3B2, POR, HSD11B2, H6PDH, HSD17B3 |
5α-Tetrahydrocortisol | Cortisol | CYP21A2, CYP11B1, CYP17A1, HSD3B2, POR, HSD11B2, H6PDH, HSD17B3, SRD5A2 |
α-Cortol | Cortisol | HSD11B2 |
β-Cortol | Cortisol | HSD11B2 |
20α-Dihydrocortisol | Cortisol | |
6β-Hydroxycortisol | Cortisol | |
18-Hydroxycortisol | Cortisol | |
Cortisone metabolites | ||
Cortisone | Cortisol, cortisone | HSD11B2 |
Tetrahydrocortisone | Cortisol, cortisone | CYP21A2, CYP11B1, CYP17A1, HSD3B2, POR, HSD11B2, H6PDH, HSD17B3 |
α-Cortolone | Cortisol, cortisone | HSD11B2 |
β-Cortolone | Cortisol, cortisone | HSD11B2 |
20α-Dihydrocortisone | Cortisol, cortisone | |
20β-Dihydrocortisone | Cortisol, cortisone |