Background
Methods
Experimental approach to the problem
Subjects
Baseline (T1) testing
Electocardiogram (ECG)
Blood collection protocol and questionnaires
Supplementation protocol
Follow-up testing and dietary intake
Variable | T1 | T2 | T3 | Time*group | Time*group*gender |
---|---|---|---|---|---|
kcal/d | |||||
PLA | 2054 ± 700 | 2132 ± 822 | 2128 ± 778 | Time p = 0.11 | G*T*Ge p = 0.17 |
LD | 2469 ± 727 | 2450 ± 957 | 2155 ± 563 | G*T p = 0.39 | |
HD | 2478 ± 1252 | 2395 ± 1139 | 2031 ± 763 | ||
Fat g/d | |||||
PLA | 85 ± 30 | 83 ± 32 | 92 ± 50 | Time p = 0.89 | G*T*Ge p = 0.41 |
LD | 101 ± 47 | 105 ± 50 | 104 ± 30 | G*T p = 0.42 | |
HD | 100 ± 60 | 94 ± 55a
| 83 ± 35a
| ||
Protein g/d | |||||
PLA | 106 ± 32 | 94 ± 28 | 96 ± 36 |
Time
p
= 0.04
| G*T*Ge p = 0.40 |
LD | 108 ± 62 | 101 ± 46 | 90 ± 34 | G*T p = 0.48 | |
HD | 110 ± 69 | 108 ± 57 | 83 ± 48 | ||
Carb g/d | |||||
PLA | 223 ± 109 | 320 ± 297 | 234 ± 91 | Time p = 0.23 | G*T*Ge p = 0.37 |
LD | 284 ± 102 | 284 ± 119 | 266 ± 89 | G*T p = 0.52 | |
HD | 282 ± 127 | 280 ± 148 | 235 ± 102 |
Statistics
Results
Effects of TeaCrine® on macronutrient intakes
Effects of TeaCrine® on body composition
Effects of TeaCrine® on clinical safety markers
Blood pressure, heart rate, and ECG variables
Variable | T1 | T2 | T3 | Time*group | Time*group*gender |
---|---|---|---|---|---|
SBP (mm Hg) | |||||
PLA | 117 ± 15 | 116 ± 12 | 115 ± 13 | Time p = 0.45 | G*T*Ge p = 0.73 |
LD | 116 ± 9 | 115 ± 8 | 116 ± 6 | G*T p = 0.12 | |
HD | 118 ± 15 | 124 ± 12 | 122 ± 13 | ||
DBP (mm Hg) | |||||
PLA | 69 ± 9 | 68 ± 9 | 68 ± 9 | Time p = 0.58 | G*T*Ge p = 0.89 |
LD | 70 ± 7 | 67 ± 8 | 71 ± 8 | G*T p = 0.53 | |
HD | 70 ± 8 | 68 ± 8 | 73 ± 8 | ||
Heart rate (beats/min) | |||||
PLA | 60 ± 10 | 64 ± 8 | 63 ± 10 |
Time
p
= 0.032
| G*T*Ge p = 0.85 |
LD | 60 ± 15 | 59 ± 10a
| 63 ± 12a
| G*T p = 0.35 | |
HD | 59 ± 12 | 63 ± 10 | 64 ± 13 | ||
Vent Rate (breath/min) | |||||
PLA | 60 ± 9 | 61 ± 10 | 62 ± 8 | Time p = 0.43 | G*T*Ge p = 0.67 |
LD | 57 ± 13 | 59 ± 11 | 60 ± 13 | G*T p = 0.10 | |
HD | 63 ± 12 | 59 ± 11 | 61 ± 11 |
Variable | T1 | T2 | T3 | Time*group | Time*group*gender |
---|---|---|---|---|---|
RR Interval (ms) | |||||
PLA | 1011 ± 148 | 991 ± 147 | 976 ± 113 | Time p = 0.23 | G*T*Ge p = 0.68 |
LD | 1095 ± 240 | 1041 ± 185 | 1035 ± 212 | G*T p = 0.55 | |
HD | 987 ± 213 | 1043 ± 221 | 1007 ± 198 | ||
PR Interval (ms) | |||||
PLA | 155 ± 25 | 155 ± 18 | 156 ± 20 | Time p = 0.49 | G*T*Ge p = 0.42 |
LD | 153 ± 18 | 153 ± 20 | 154 ± 17 | G*T p = 0.33 | |
HD | 150 ± 24 | 144 ± 24 | 143 ± 19 | ||
QRS Duration (ms) | |||||
PLA | 95 ± 11 | 91 ± 22 | 96 ± 12 | Time p = 0.32 | G*T*Ge p = 0.25 |
LD | 93 ± 12 | 93 ± 11 | 94 ± 11 | G*T p = 0.41 | |
HD | 92 ± 13 | 92 ± 12 | 92 ± 12 | ||
QT Interval (ms) | |||||
PLA | 428 ± 27 | 424 ± 31 | 424 ± 25 | Time p = 0.33 | G*T*Ge p = 0.38 |
LD | 427 ± 40 | 424 ± 36 | 419 ± 38 | G*T p = 0.36 | |
HD | 409 ± 26 | 614 ± 904 | 418 ± 38 | ||
QTc Interval (ms) | |||||
PLA | 429 ± 17 | 426 ± 19 | 427 ± 22 | Time p = 0.89 | G*T*Ge p = 0.35 |
LD | 421 ± 24 | 422 ± 22 | 419 ± 23 | G*T p = 0.33 | |
HD | 414 ± 19 | 417 ± 20 | 419 ± 27 | ||
QT Dispersion (ms) | |||||
PLA | 38 ± 25 | 33 ± 18 | 36 ± 42 | Time p = 0.78 | G*T*Ge p = 0.11 |
LD | 35 ± 21 | 51 ± 90 | 38 ± 25 | G*T p = 0.51 | |
HD | 41 ± 27 | 32 ± 21 | 32 ± 27 | ||
P Axis (degrees) | |||||
PLA | 54 ± 31 | 65 ± 12 | 59 ± 25 | Time p = 0.66 | G*T*Ge p = 0.88 |
LD | 52 ± 37 | 53 ± 37 | 53 ± 35 |
G*T
p
= 0.033
| |
HD | 61 ± 15 | 54 ± 19 | 59 ± 17 | ||
R Axis (degrees) | |||||
PLA | 73 ± 32 | 78 ± 26 | 76 ± 33 | Time p = 0.81 | G*T*Ge p = 0.13 |
LD | 74 ± 25 | 67 ± 33 | 72 ± 26 | G*T p = 0.38 | |
HD | 85 ± 9 | 84 ± 9 | 84 ± 11 | ||
T Axis (degrees) | |||||
PLA | 54 ± 20 | 415 ± 1587 | 59 ± 14 | Time p = 0.15 | G*T*Ge p = 0.34 |
LD | 61 ± 17 | 438 ± 1653 | 60 ± 17 | G*T p = 0.90 | |
HD | 200 ± 634 | 312 ± 1160 | 60 ± 17 |
Clinical blood safety markers
Variable | T1 | T2 | T3 | Time*group | Time*group*gender |
---|---|---|---|---|---|
Cholesterol (mg/dL) | |||||
PLA | 155 ± 37 | 154 ± 34 | 161 ± 32 | Time p = 0.07 | G*T*Ge p = 0.38 |
LD | 151 ± 28 | 150 ± 26 | 160 ± 28 |
G*T
p
= 0.001
| |
HD |
174 ± 33
|
162 ± 33
†
|
160 ± 32
†
| ||
HDL (mg/dL) | |||||
PLA | 49 ± 10 | 51 ± 12 | 55 ± 12 | Time p = 0.08 | G*T*Ge p = 0.99 |
LD | 47 ± 11 | 50 ± 12 | 51 ± 12 | G*T p = 0.16 | |
HD | 53 ± 16 | 49 ± 15 | 52 ± 16 | ||
LDL (mg/dL) | |||||
PLA | 89.4 ± 28.9 | 83.4 ± 28.9 | 87.7 ± 23.9 |
Time
p
= 0.001
| G*T*Ge p = 0.38 |
LD | 85.0 ± 19.8 | 78.9 ± 17.8 | 86.9 ± 22.2 |
G*T
p
= 0.024
| |
HD |
103.0 ± 22.1
|
89.3 ± 20.5
†
|
89.2 ± 19.9
†
| ||
Cholesterol/HDL | |||||
PLA | 3.3 ± 0.9 | 3.1 ± 0.9 | 3.0 ± 0.8 | Time p = 0.19 | G*T*Ge p = 0.48 |
LD | 3.2 ± 0.8 | 3.0 ± 0.8 | 3.2 ± 0.9 | G*T p = 0.77 | |
HD | 35 ± 0.9 | 3.3 ± 0.9 | 3.3 ± 0.9 | ||
Triglycerides (mg/dL) | |||||
PLA | 67 ± 25 | 77 ± 31 | 73 ± 31 | Time p = 0.21 | G*T*Ge p = 0.73 |
LD | 80 ± 45 | 93 ± 50 | 97 ± 50 | G*T p = 0.63 | |
HD | 87 ± 39 | 92 ± 40 | 83 ± 36 | ||
Glucose (mg/dL) | |||||
PLA | 86 ± 8 | 86 ± 8 | 86 ± 6 | Time p = 0.14 | G*T*Ge p = 0.44 |
LD | 87 ± 7 | 86 ± 8 | 90 ± 8 | G*T p = 0.55 | |
HD | 84 ± 9 | 86 ± 9 | 86 ± 7 |
Variable | T1 | T2 | T3 | Time*group | Time*group*gender |
---|---|---|---|---|---|
Urea Nitrogen (mg/dL) | |||||
PLA | 16 ± 4 | 15 ± 4 | 16 ± 5 | Time p = 0.89 | G*T*Ge p = 0.39 |
LD | 14 ± 3 | 14 ± 3 | 15 ± 3 | G*T p = 0.34 | |
HD | 15 ± 4 | 13 ± 4 | 14 ± 3 | ||
Creatinine (mg/dL) | |||||
PLA | 1.18 ± 0.2 | 0.96 ± 0.2 | 0.97 ± 0.2 | Time p = 0.33 |
G*T*Ge
p
= 0.046
|
LD | 0.97 ± 0.1 | 1.02 ± 0.2 |
1.03 ± 0.2
‡
| G*T p = 0.06 | |
HD | 0.99 ± 0.2 | 1.01 ± 0.2 | 1.05 ± 0.2 | ||
Sodium (mmoL) | |||||
PLA | 140.65 ± 3 | 139.85 ± 2 | 140.95 ± 2 |
Time
p
= 0.007
| G*T*Ge p = 0.84 |
LD | 141.22 ± 2 | 140.17 ± 2 | 140.95 ± 3 | G*T p = 0.67 | |
HD | 141.19 ± 3 |
139.95 ± 2
†
| 140.24 ± 2 | ||
Potassium (mmoL) | |||||
PLA | 4.9 ± 0.4 | 4.7 ± 0.6 | 4.9 ± 0.5 | Time p = 0.22 | G*T*Ge p = 0.99 |
LD | 5.0 ± 0.6 | 4.8 ± 0.4 | 4.9 ± 0.5 | G*T p = 0.97 | |
HD | 4.9 ± 0.4 | 4.8 ± 0.4 | 4.9 ± 0.4 | ||
Chloride (mmoL) | |||||
PLA | 105.60 ± 2 |
104.45 ± 2
†
| 105.00 ± 2 |
Time
p
= 0.006
| G*T*Ge p = 0.60 |
LD | 105.89 ± 2 | 105.33 ± 2 | 104.84 ± 2 | G*T p = 0.78 | |
HD | 105.24 ± 2 |
104.33 ± 2
†
| 104.57 ± 2 | ||
Calcium (mg/dL) | |||||
PLA | 9.7 ± 0.5 | 9.5 ± 0.4 | 9.6 ± 0.4 | Time p = 0.37 | G*T*Ge p = 0.74 |
LD | 9.6 ± 0.3 | 9.6 ± 0.4 | 9.6 ± 0.3 | G*T p = 0.20 | |
HD | 9.8 ± 0.3 | 9.7 ± 0.4 | 9.7 ± 0.3 | ||
Carbon Dioxide (mmoL) | |||||
PLA | 24 ± 2 | 25 ± 2 | 24 ± 2 | Time p = 0.65 | G*T*Ge p = 0.95 |
LD | 26 ± 2 | 26 ± 2 | 25 ± 2 | G*T p = 0.85 | |
HD | 25 ± 2 | 25 ± 2 | 25 ± 2 |
Variable | T1 | T2 | T3 | Time*group | Time*group*gender |
---|---|---|---|---|---|
Serum protein (g/dL) | |||||
PLA | 7.0 ± 0.4 | 6.8 ± 0.4 | 7.0 ± 0.4 |
Time
p
= 0.011
| G*T*Ge p = 0.97 |
LD | 7.0 ± 0.5 | 6.8 ± 0.4 | 7.0 ± 0.4 |
G*T
p
= 0.006
| |
HD | 7.2 ± 0.4 | 7.0 ± 0.5 |
6.9 ± 0.3
†
| ||
Albumin (g/dL) | |||||
PLA | 4.6 ± 0.4 | 4.4 ± 0.4 | 4.5 ± 0.4 |
Time
p
= 0.023
| G*T*Ge p = 0.67 |
LD | 4.5 ± 0.3 | 4.5 ± 0.3 | 4.6 ± 0.3 | G*T p = 0.17 | |
HD | 4.5 ± 0.3 | 4.5 ± 0.3 | 4.4 ± 0.2 | ||
Globulin (g/dL) | |||||
PLA | 2.5 ± 0.3 | 2.4 ± 0.3 | 2.5 ± 0.2 | Time p = 0.15 | G*T*Ge p = 0.85 |
LD | 2.4 ± 0.4 | 2.3 ± 0.3 | 2.5 ± 0.3 | G*T p = 0.10 | |
HD | 2.6 ± 0.4 | 2.5 ± 0.4 | 2.4 ± 0.4 | ||
Albumin/Globulin | |||||
PLA | 1.9 ± 0.3 | 1.9 ± 0.3 | 1.9 ± 0.3 | Time p = 0.76 | G*T*Ge p = 0.72 |
LD | 1.9 ± 0.3 | 1.9 ± 0.3 | 1.9 ± 0.2 | G*T p = 0.66 | |
HD | 1.8 ± 0.4 | 1.8 ± 0.4 | 1.8 ± 0.3 | ||
Bilirubin (mg/dL) | |||||
PLA | 0.7 ± 0.3 | 0.7 ± 0.4 | 0.8 ± 0.5 | Time p = 0.84 | G*T*Ge p = 0.40 |
LD | 0.7 ± 0.3 | 0.7 ± 0.3 | 0.6 ± 0.3 | G*T p = 0.44 | |
HD | 0.7 ± 0.3 | 0.7 ± 0.3 | 0.6 ± 0.3 | ||
ALP (IU/L) | |||||
PLA | 58 ± 17 | 57 ± 15 | 58 ± 15 | Time p = 0.47 | G*T*Ge p = 0.36 |
LD | 53 ± 11 | 55 ± 12 | 57 ± 12 | G*T p = 0.25 | |
HD | 65 ± 13 | 60 ± 15 | 62 ± 13 | ||
AST (IU/L) | |||||
PLA | 21 ± 6 | 19 ± 5 | 20 ± 4 | Time p = 0.12 | G*T*Ge p = 0.66 |
LD | 19 ± 5 | 18 ± 4 | 20 ± 7 | G*T p = 0.81 | |
HD | 20 ± 6 | 18 ± 6 | 20 ± 7 | ||
ALT (IU/L) | |||||
PLA | 17 ± 7 | 17 ± 6 | 17 ± 6 | Time p = 0.34 | G*T*Ge p = 0.45 |
LD | 17 ± 7 | 17 ± 8 | 23 ± 24 | G*T p = 0.19 | |
HD | 19 ± 8 | 17 ± 12 | 17 ± 6 |
Variable | T1 | T2 | T3 | Time*group | Time*group*gender |
---|---|---|---|---|---|
White blood cells (103 cells/μL) | |||||
PLA | 6.0 ± 1.8 | 5.9 ± 1.7 | 6.2 ± 1.6 | Time p = 0.52 | G*T*Ge p = 0.18 |
LD | 6.5 ± 1.5 | 6.3 ± 1.5 | 6.4 ± 1.5 | G*T p = 0.52 | |
HD | 6.9 ± 1.5 | 6.5 ± 1.2 | 6.4 ± 1.8 | ||
RBC (106 cells/μl) | |||||
PLA | 4.4 ± 0.4 | 4.4 ± 0.5 | 4.5 ± 0.4 | Time p = 0.12 | G*T*Ge p = 0.10 |
LD | 4.8 ± 0.4 | 4.7 ± 0.4 | 4.8 ± 0.4 | G*T p = 0.36 | |
HD | 4.8 ± 0.4 | 4.8 ± 0.5 | 4.8 ± 0.5 | ||
Hemoglobin (g/dL) | |||||
PLA | 13.8 ± 1.0 | 13.7 ± 1.5 |
13.9 ± 1.3
‡
| Time p = 0.56 |
G*T*Ge
p
= 0.006
|
LD | 14.4 ± 1.1 | 14.3 ± 1.1 | 14.5 ± 1.1 | G*T p = 0.78 | |
HD | 14.2 ± 1.4 | 14.1 ± 1.3 | 14.1 ± 1.4 | ||
Hematocrit (%) | |||||
PLA | 41 ± 3 | 41 ± 5 |
42 ± 3
‡
| Time p = 0.23 |
G*T*Ge
p
= 0.049
|
LD | 43 ± 4 | 43 ± 3 | 44 ± 3 | G*T p = 0.85 | |
HD | 43 ± 4 | 43 ± 4 | 43 ± 4 | ||
Platelet Count (103 particles/μL) | |||||
PLA | 160 ± 46 |
191 ± 50
†
| 204 ± 89 |
Time
p
= 0.005
| G*T*Ge p = 0.16 |
LD | 148 ± 61 | 176 ± 35 | 212 ± 71 | G*T p = 0.77 | |
HD | 191 ± 40 | 216 ± 51 | 227 ± 41 | ||
Neutrophils (103 cells/μL) | |||||
PLA | 3123 ± 843 | 3441 ± 1440 | 3679 ± 1443 | Time p = 0.67 | G*T*Ge p = 0.12 |
LD | 3423 ± 920 | 3196 ± 862 | 3444 ± 881 | G*T p = 0.28 | |
HD | 3631 ± 1417 | 3570 ± 921 | 3452 ± 1423 | ||
Lymphocytes (103 cells/μL) | |||||
PLA | 1881 ± 543 | 1908 ± 479 | 1928 ± 492 | Time p = 0.20 | G*T*Ge p = 0.50 |
LD | 2393 ± 698 | 2325 ± 738 | 2232 ± 681 | G*T p = 0.13 | |
HD | 2624 ± 664 | 2200 ± 425 | 2384 ± 761 | ||
Monocytes (103 cells/μL) | |||||
PLA | 426 ± 123 | 414 ± 150 | 412 ± 131 | Time p = 0.97 | G*T*Ge p = 0.07 |
LD | 467 ± 149 | 498 ± 131 | 456 ± 156 | G*T p = 0.65 | |
HD | 424 ± 184 | 399 ± 106 | 427 ± 123 | ||
Eosinophils (103 cells/μL) | |||||
PLA | 157 ± 109 |
187 ± 125
†
| 166 ± 115 | Time p = 0.62 |
G*T*Ge
p
= 0.002
|
LD | 187 ± 108 | 187 ± 102 | 189 ± 112 |
G*T
p
= 0.041
| |
HD | 225 ± 130 | 164 ± 87 | 181 ± 83 | ||
Basophils (103 cells/μL) | |||||
PLA | 27 ± 12 | 24 ± 11 | 25 ± 12 | Time p = 0.07 | G*T*Ge p = 0.28 |
LD | 30 ± 14 | 36 ± 19 | 25 ± 11 | G*T p = 0.21 | |
HD | 32 ± 18 | 43 ± 23 | 33 ± 20 |
Effects of Teacrine® on mood and concentration profiles
Variable | T1 | T2 | T3 | Time*group | Time*group*gender |
---|---|---|---|---|---|
POMS Tension | |||||
PLA | 13 ± 4 | 13 ± 5 | 14 ± 4 | Time p = 0.09 | G*T*Ge p = 0.61 |
LD | 13 ± 3 | 14 ± 5 | 14 ± 4 | G*T p = 0.98 | |
HD | 14 ± 4 | 15 ± 4 | 15 ± 4 | ||
POMS Depression | |||||
PLA | 16 ± 3 | 16 ± 4 | 17 ± 4 | Time p = 0.12 | G*T*Ge p = 0.47 |
LD | 16 ± 2 | 17 ± 5 | 17 ± 3 | G*T p = 0.55 | |
HD | 17 ± 2 | 18 ± 6 | 17 ± 5 | ||
POMS Anger | |||||
PLA | 13.3 ± 2.4 | 13.9 ± 2.8 | 14.0 ± 3.7 | Time p = 0.50 | G*T*Ge p = 0.97 |
LD | 13.0 ± 1.8 | 13.7 ± 4.2 | 13.5 ± 3.6 | G*T p = 0.65 | |
HD | 13.7 ± 2.4 | 13.4 ± 2.1 | 13.5 ± 2.9 | ||
POMS Vigor | |||||
PLA | 22 ± 5 | 22 ± 6 | 21 ± 6 |
Time
p
= 0.021
|
G*T*Ge
p
= 0.044
|
LD | 23 ± 5 |
19 ± 6
†
|
23 ± 6
‡
|
G*T
p
= 0.006
| |
HD | 21 ± 5 | 20 ± 6 | 19 ± 5 | ||
POMS Fatigue | |||||
PLA | 11 ± 3 | 12 ± 5 | 14 ± 5 |
Time
p
= 0.031
| G*T*Ge p = 0.79 |
LD | 11 ± 4 | 12 ± 5 | 11 ± 4 | G*T p = 0.41 | |
HD | 13 ± 5 | 14 ± 5 | 15 ± 6 | ||
POMS Confusion | |||||
PLA | 12 ± 2 | 13 ± 3 | 13 ± 3 | Time p = 0.64 | G*T*Ge p = 0.22 |
LD | 13 ± 2 | 13 ± 2 | 13 ± 3 | G*T p = 0.65 | |
HD | 13 ± 3 | 14 ± 4 | 13 ± 3 | ||
POMS Total | |||||
PLA | 44 ± 13 | 45 ± 17 | 49 ± 16 |
Time
p
= 0.023
| G*T*Ge p = 0.62 |
LD | 43 ± 10 | 50 ± 20 | 45 ± 15 | G*T p = 0.50 | |
HD | 51 ± 15 | 58 ± 23 | 58 ± 20 |