Background
Methods
Patients
Radiotherapy and chemotherapy
Follow up and evaluation
Statistical analysis
Results
Patient characteristics
Factors | RT group (n = 13) | Non-RT group (n = 14) | p-value | |
---|---|---|---|---|
Age, yr. (mean ± SD) | 66 ± 5 | 68 ± 7.4 | 0.31 | |
Gender | Male | 10 | 12 | 0.65 |
Female | 3 | 2 | ||
Number of primary tumors | Single | 12 | 10 | 0.36 |
Multiple | 1 | 4 | ||
Location of tumor | Ut | 3 | 2 | 0.59 |
Mt | 8 | 11 | ||
Lt | 2 | 1 | ||
Invasion depth | pT1a-MM | 6 | 10 | 0.25 |
pT1b-SM1 | 7 | 4 | ||
Circumferential extent of ESD | < 3/4 | 7 | 10 | 0.44 |
≥3/4 | 6 | 4 | ||
Longitudinal diameter of ESD (mm; mean ± SD) | 43 ± 17 | 42 ± 21 | 0.88 | |
Positive resection margin | 1 | 0 | 1.00 | |
Positive lymphatic invasion | 1 | 0 | 0.48 | |
Positive vascular invasion | 0 | 0 | 1.00 | |
Additional chemotherapy | (+) | 4 | 4 | 1.00 |
(−) | 9 | 10 |
Additional radiotherapy improved locoregional control but not survival
Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|
Factors | Number | 3-year LRC (%) | p-value | p-value | |
Age, yr | ≥65 | 18 | 86 | 0.51 | (−) |
< 65 | 9 | 67 | |||
Gender | Male | 22 | 78 | 0.46 | (−) |
Female | 5 | 100 | |||
Number of primary tumors | Single | 22 | 82 | 0.48 | (−) |
Multiple | 5 | 75 | |||
Invasion depth | pT1a-MM | 16 | 71 | 0.24 | (−) |
pT1b-SM1 | 11 | 90 | |||
Circumferential extent of ESD | < 3/4 | 17 | 83 | 0.71 | (−) |
≥3/4 | 10 | 77 | |||
Longitudinal diameter of ESD (mm) | < 40 | 13 | 76 | 0.77 | (−) |
≥40 | 14 | 83 | |||
Additional chemotherapy | (+) | 8 | 60 | 0.16 | 0.039* |
(−) | 19 | 87 | |||
Additional RT | (+) | 13 | 100 | 0.022* | 0.0022* |
(−) | 14 | 58 |
Treatment-related esophageal stricture and other adverse events
Additional RT | Toxicity grade | Invasion depth | Circumference of ESDa | Longitudinal diameter of ESD (mm) | Treatment of strictures | Outcome of strictures |
---|---|---|---|---|---|---|
(+) | Grade 2 | pT1a-MM | 5/6 | 68 | EBD | Improved |
(+) | Grade 3 | pT1b-SM1 | Complete | 75 | EBD, stent | Remained |
(−) | Grade 2 | pT1a-MM | 3/4 | 55 | EBD | Improved |
(−) | Grade 3 | pT1a-MM | Complete | 90 | EBD | Remained |
Factors | Esophageal stricture (n = 4) | No esophageal stricture (n = 23) | p-Value | |
---|---|---|---|---|
Age (years; mean ± SD) | 65 ± 6.5 | 67 ± 1.4 | 0.61 | |
Gender | Male | 2 | 20 | 0.14 |
Female | 2 | 3 | ||
Number of primary tumors | Single | 1 | 21 | 0.013* |
Multiple | 3 | 2 | ||
Invasion depth | pT1a-MM | 3 | 13 | 0.62 |
pT1b-SM1 | 1 | 10 | ||
Circumferential extent of ESD | < 3/4 | 0 | 17 | 0.012* |
≥3/4 | 4 | 6 | ||
Longitudinal diameter of ESD (mm; mean ± SD) | 72 ± 14 | 38 ± 14 | 0.0033* | |
Additional chemotherapy | (+) | 1 | 7 | 1.00 |
(−) | 3 | 16 | ||
Additional RT | (+) | 2 | 11 | 1.00 |
(−) | 2 | 12 |