Skip to main content
Erschienen in: Drugs & Aging 8/2003

01.07.2003 | Therapy In Practice

Sleep Apnoea In The Older Adult

Pathophysiology, Epidemiology, Consequences And Management

verfasst von: Dr Tamar Shochat, Giora Pillar

Erschienen in: Drugs & Aging | Ausgabe 8/2003

Einloggen, um Zugang zu erhalten

Abstract

Sleep apnoea is a breathing disorder in sleep usually caused by repetitive upper airway obstruction. Its primary symptoms include snoring, daytime sleepiness and decreased cognitive functioning. Risk factors for the condition include obesity, anatomical abnormalities, aging, and family history. It has been associated with hypertension, cardiovascular and pulmonary diseases and increased mortality. The prevalence of sleep apnoea increases with age, although the severity of the disorder, as well as the morbidity and mortality associated with it, may actually decrease in the elderly. A decline in cognitive functioning in older adults with sleep apnoea may resemble dementia.
Medical management of sleep apnoea rarely relies on drug treatment, as the few drugs (antidepressants and respiratory stimulants) tested for treatment have been found to be ineffective, or cause tolerance or serious adverse effects and complications. The treatment of choice for sleep apnoea is continuous positive airway pressure, a device which generates positive air pressure through a nose mask, creating a splint which keeps the airway unobstructed throughout the night. Weight loss significantly decreases or eliminates apnoeas. Oral appliances are used to enlarge the airway at night by moving the tongue and mandible forward. Positional therapy involves avoiding the supine position during sleep in patients who mostly have apnoeas while lying on their back. Surgical management may also be considered, although with great caution in the elderly, because of their increased risk of complications related to surgery. Surgical procedures include nasal reconstruction, somnoplasty, laser-assisted uvuloplasty, uvulopalato-pharyngoplasty, genioglossus advancement and hyoid myotomy, and maxillo-mandibular advancement for severe cases when other treatments have failed. As a last option, tracheostomy may be performed.
Literatur
1.
Zurück zum Zitat Guilleminault C, Tilkian A, Dement WC. The sleep apnea syndromes. Annu Rev Med 1976; 27: 465–84PubMedCrossRef Guilleminault C, Tilkian A, Dement WC. The sleep apnea syndromes. Annu Rev Med 1976; 27: 465–84PubMedCrossRef
3.
Zurück zum Zitat Isono S, Remmers JE, Tanaka A, et al. Anatomy of pharynx in patients with obstructive sleep apnea and in normal subjects. J Appl Physiol 1997 Apr; 82(4): 1319–26PubMed Isono S, Remmers JE, Tanaka A, et al. Anatomy of pharynx in patients with obstructive sleep apnea and in normal subjects. J Appl Physiol 1997 Apr; 82(4): 1319–26PubMed
4.
Zurück zum Zitat Mezzanotte WS, Tangel DJ, White DP. Waking genioglossal EMG in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J Clin Invest 1992 May; 89(5): 1571–9PubMedCrossRef Mezzanotte WS, Tangel DJ, White DP. Waking genioglossal EMG in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J Clin Invest 1992 May; 89(5): 1571–9PubMedCrossRef
5.
Zurück zum Zitat Malhotra A, Crowley S, Pillar G, et al. Age-related changes in pharyngeal structure and function in normal subjects [abstract]. Sleep 2000 Apr; 161Suppl. 2: A42 Malhotra A, Crowley S, Pillar G, et al. Age-related changes in pharyngeal structure and function in normal subjects [abstract]. Sleep 2000 Apr; 161Suppl. 2: A42
6.
Zurück zum Zitat Naughton MT, Bradley TD. Sleep apnea in congestive heart failure. Clin Chest Med 1998 Mar; 19(1): 99–113PubMedCrossRef Naughton MT, Bradley TD. Sleep apnea in congestive heart failure. Clin Chest Med 1998 Mar; 19(1): 99–113PubMedCrossRef
7.
Zurück zum Zitat Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993 Apr; 328(17): 1230–5PubMedCrossRef Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993 Apr; 328(17): 1230–5PubMedCrossRef
8.
Zurück zum Zitat Ohayon MM, Guilleminault C, Priest RG, et al. Snoring and breathing pauses during sleep: telephone interview survey of a United Kingdom population sample. BMJ 1997 Mar 22; 314(7084): 860–3PubMedCrossRef Ohayon MM, Guilleminault C, Priest RG, et al. Snoring and breathing pauses during sleep: telephone interview survey of a United Kingdom population sample. BMJ 1997 Mar 22; 314(7084): 860–3PubMedCrossRef
9.
Zurück zum Zitat Enright PL, Newman AB, Wahl PW, et al. Prevalence and correlates of snoring and observed apneas in 5201 older adults. Sleep 1996 Sep; 19(7): 531–8PubMed Enright PL, Newman AB, Wahl PW, et al. Prevalence and correlates of snoring and observed apneas in 5201 older adults. Sleep 1996 Sep; 19(7): 531–8PubMed
10.
Zurück zum Zitat Ancoli-Israel S, Kripke DF, Klauber MR, et al. Sleep disordered breathing in community-dwelling elderly. Sleep 1991 Dec; 14(6): 486–95PubMed Ancoli-Israel S, Kripke DF, Klauber MR, et al. Sleep disordered breathing in community-dwelling elderly. Sleep 1991 Dec; 14(6): 486–95PubMed
11.
Zurück zum Zitat Peppard PE, Young T, Palta M, et al. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA 2000 Dec; 284(23): 3015–21PubMedCrossRef Peppard PE, Young T, Palta M, et al. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA 2000 Dec; 284(23): 3015–21PubMedCrossRef
12.
Zurück zum Zitat Ancoli-Israel S, Gehrman P, Kripke DF, et al. Long-term follow up of sleep disordered breathing in older adults. Sleep Med 2001 Nov; 2(6): 511–6PubMedCrossRef Ancoli-Israel S, Gehrman P, Kripke DF, et al. Long-term follow up of sleep disordered breathing in older adults. Sleep Med 2001 Nov; 2(6): 511–6PubMedCrossRef
13.
Zurück zum Zitat Redline S, Tishler PV, Tosteson TD, et al. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med 1995 Mar; 151 (3 pt 1): 682–7PubMed Redline S, Tishler PV, Tosteson TD, et al. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med 1995 Mar; 151 (3 pt 1): 682–7PubMed
14.
Zurück zum Zitat Guilleminault C, Partinen M, Hollman K, et al. Familial aggregates in obstructive sleep apnea syndrome. Chest 1995 Jun; 107(6): 1545–51PubMedCrossRef Guilleminault C, Partinen M, Hollman K, et al. Familial aggregates in obstructive sleep apnea syndrome. Chest 1995 Jun; 107(6): 1545–51PubMedCrossRef
15.
Zurück zum Zitat Pillar G, Lavie P. Assessment of the role of inheritance in sleep apnea syndrome. Am J Respir Crit Care Med 1995 Mar; 151 (3 pt 1): 688–91PubMed Pillar G, Lavie P. Assessment of the role of inheritance in sleep apnea syndrome. Am J Respir Crit Care Med 1995 Mar; 151 (3 pt 1): 688–91PubMed
16.
Zurück zum Zitat Pillar G, Schnall RP, Peled N, et al. Impaired respiratory response to resistive loading during sleep in healthy offspring of patients with obstructive sleep apnea. Am J Respir Crit Care Med 1997 May; 155(5): 1602–8PubMed Pillar G, Schnall RP, Peled N, et al. Impaired respiratory response to resistive loading during sleep in healthy offspring of patients with obstructive sleep apnea. Am J Respir Crit Care Med 1997 May; 155(5): 1602–8PubMed
17.
Zurück zum Zitat Grunstein RR, Sullivan CE. Sleep apnea and hypothyroidism: mechanisms and management. Am J Med 1988 Dec; 85(6): 775–9PubMedCrossRef Grunstein RR, Sullivan CE. Sleep apnea and hypothyroidism: mechanisms and management. Am J Med 1988 Dec; 85(6): 775–9PubMedCrossRef
18.
Zurück zum Zitat Rosenow F, McCarthy V, Caruso AC. Sleep apnoea in endocrine diseases. J Sleep Res 1998; 7(1): 3–11PubMedCrossRef Rosenow F, McCarthy V, Caruso AC. Sleep apnoea in endocrine diseases. J Sleep Res 1998; 7(1): 3–11PubMedCrossRef
19.
Zurück zum Zitat Weiss V, Sonka K, Pretl M, et al. Prevalence of the sleep apnea syndrome in acromegaly population. J Endocrinol Invest 2000; 23(8): 515–9PubMed Weiss V, Sonka K, Pretl M, et al. Prevalence of the sleep apnea syndrome in acromegaly population. J Endocrinol Invest 2000; 23(8): 515–9PubMed
20.
Zurück zum Zitat Lavie P, Herer P, Hoffstein V. Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study. BMJ 2000 Feb; 320(7233): 479–82PubMedCrossRef Lavie P, Herer P, Hoffstein V. Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study. BMJ 2000 Feb; 320(7233): 479–82PubMedCrossRef
21.
Zurück zum Zitat Bixler EO, Vgontzas AN, Lin HM, et al. Association of hypertension and sleep-disordered breathing. Arch Intern Med 2000 Aug; 160(15): 2289–95PubMedCrossRef Bixler EO, Vgontzas AN, Lin HM, et al. Association of hypertension and sleep-disordered breathing. Arch Intern Med 2000 Aug; 160(15): 2289–95PubMedCrossRef
22.
Zurück zum Zitat Nieto FJ, Young TB, Lind BK, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 2000 Apr; 283(14): 1829–36PubMedCrossRef Nieto FJ, Young TB, Lind BK, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 2000 Apr; 283(14): 1829–36PubMedCrossRef
23.
Zurück zum Zitat Shahar E, Whitney CW, Redline S, et al. Sleep disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med 2001 Jan; 163(1): 19–25PubMed Shahar E, Whitney CW, Redline S, et al. Sleep disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med 2001 Jan; 163(1): 19–25PubMed
24.
Zurück zum Zitat Fisher D, Pillar G, Malhotra A, et al. Long term follow up of untreated patients with sleep apnea. Sleep Med 2002; 96: 337–43 Fisher D, Pillar G, Malhotra A, et al. Long term follow up of untreated patients with sleep apnea. Sleep Med 2002; 96: 337–43
25.
Zurück zum Zitat Lavie P, Herer P, Peled R, et al. Mortality in sleep apnea patients: a multivariate analysis of risk factors. Sleep 1995 Apr; 18(3): 149–57PubMed Lavie P, Herer P, Peled R, et al. Mortality in sleep apnea patients: a multivariate analysis of risk factors. Sleep 1995 Apr; 18(3): 149–57PubMed
26.
Zurück zum Zitat Ancoli-Israel S, Kripke DF, Klauber MR, et al. Morbidity, mortality and sleep disordered breathing in community dwelling elderly. Sleep 1996 May; 19(4): 277–82PubMed Ancoli-Israel S, Kripke DF, Klauber MR, et al. Morbidity, mortality and sleep disordered breathing in community dwelling elderly. Sleep 1996 May; 19(4): 277–82PubMed
27.
Zurück zum Zitat He J, Kryger MH, Zorik FJ, et al. Mortality and apnoea index in obstructive sleep apnea: experience in 385 male patients. Chest 1988 Jul; 94(1): 9–14PubMedCrossRef He J, Kryger MH, Zorik FJ, et al. Mortality and apnoea index in obstructive sleep apnea: experience in 385 male patients. Chest 1988 Jul; 94(1): 9–14PubMedCrossRef
28.
Zurück zum Zitat Mosko SS, Dickel MJ, Paul T, et al. Sleep apnea and sleep-related periodic leg movements in community resident seniors. J Am Geriatr Soc 1988 Jun; 36(6): 502–8PubMed Mosko SS, Dickel MJ, Paul T, et al. Sleep apnea and sleep-related periodic leg movements in community resident seniors. J Am Geriatr Soc 1988 Jun; 36(6): 502–8PubMed
29.
Zurück zum Zitat Bliwise DL. Sleep in normal aging and dementia. Sleep 1993 Jan; 16(1): 40–81PubMed Bliwise DL. Sleep in normal aging and dementia. Sleep 1993 Jan; 16(1): 40–81PubMed
30.
Zurück zum Zitat Findley LJ, Barth JT, Powers DC, et al. Cognitive impairment in patients with obstructive sleep apnea and associated hypoxemia. Chest 1986 Nov; 90(5): 686–90PubMedCrossRef Findley LJ, Barth JT, Powers DC, et al. Cognitive impairment in patients with obstructive sleep apnea and associated hypoxemia. Chest 1986 Nov; 90(5): 686–90PubMedCrossRef
31.
Zurück zum Zitat Greenberg GD, Watson RK, Deptula D. Neuropsychological dysfunction in sleep apnea. Sleep 1987 Jun; 10(3): 254–62PubMed Greenberg GD, Watson RK, Deptula D. Neuropsychological dysfunction in sleep apnea. Sleep 1987 Jun; 10(3): 254–62PubMed
32.
Zurück zum Zitat Redline S, Strauss ME, Adams N, et al. Neuropsychological function in mild sleep disordered breathing. Sleep 1997 Feb; 20(2): 160–7PubMed Redline S, Strauss ME, Adams N, et al. Neuropsychological function in mild sleep disordered breathing. Sleep 1997 Feb; 20(2): 160–7PubMed
33.
Zurück zum Zitat Cohen-Zion M, Stepnowsky C, Marler M, et al. Changes in cognitive function associated with sleep disordered breathing in older people. J Am Geriatr Soc 2001 Dec; 49(12): 1622–7PubMedCrossRef Cohen-Zion M, Stepnowsky C, Marler M, et al. Changes in cognitive function associated with sleep disordered breathing in older people. J Am Geriatr Soc 2001 Dec; 49(12): 1622–7PubMedCrossRef
34.
Zurück zum Zitat Bedard MA, Montplaisir J, Richer F, et al. Obstructive sleep apnea syndrome: pathogenesis of neuropsychological deficits. J Clin Exp Neuropsych 1991 Nov; 13(6): 950–64CrossRef Bedard MA, Montplaisir J, Richer F, et al. Obstructive sleep apnea syndrome: pathogenesis of neuropsychological deficits. J Clin Exp Neuropsych 1991 Nov; 13(6): 950–64CrossRef
35.
Zurück zum Zitat Pillar G, Lavie P. Psychiatric symptoms in sleep apnea syndrome: effects of gender and respiratory disturbance index. Chest 1998; 114: 697–703PubMedCrossRef Pillar G, Lavie P. Psychiatric symptoms in sleep apnea syndrome: effects of gender and respiratory disturbance index. Chest 1998; 114: 697–703PubMedCrossRef
36.
Zurück zum Zitat Ancoli-Israel S, Klauber MR, Butters N, et al. Dementia in institutionalized elderly: relation to sleep apnea. J Am Geriatr Soc 1991 Mar; 39(3): 258–63PubMed Ancoli-Israel S, Klauber MR, Butters N, et al. Dementia in institutionalized elderly: relation to sleep apnea. J Am Geriatr Soc 1991 Mar; 39(3): 258–63PubMed
37.
Zurück zum Zitat Hoch CC, Reynolds III CF, Kupfer DJ, et al. Sleep disordered breathing in normal and pathological aging. J Clin Psychiatry 1986 Oct; 47(10): 499–503PubMed Hoch CC, Reynolds III CF, Kupfer DJ, et al. Sleep disordered breathing in normal and pathological aging. J Clin Psychiatry 1986 Oct; 47(10): 499–503PubMed
38.
Zurück zum Zitat Erkinjuntti T, Partinen M, Sulkava R, et al. Sleep apnea in multiinfarct dementia and Alzheimer’s disease. Sleep 1987 Oct; 10(5): 419–25PubMed Erkinjuntti T, Partinen M, Sulkava R, et al. Sleep apnea in multiinfarct dementia and Alzheimer’s disease. Sleep 1987 Oct; 10(5): 419–25PubMed
39.
Zurück zum Zitat Bliwise DL, Yesavage JA, Tinklenberg JR, et al. Sleep apnea in Alzheimer’s disease. Neurobiol Aging 1989 Jul–Aug; 10(4): 343–6PubMedCrossRef Bliwise DL, Yesavage JA, Tinklenberg JR, et al. Sleep apnea in Alzheimer’s disease. Neurobiol Aging 1989 Jul–Aug; 10(4): 343–6PubMedCrossRef
40.
Zurück zum Zitat Dickel MJ, Mosko SS. Morbidity cut-offs for sleep apnea and periodic leg movements in predicting subjective complaints in seniors. Sleep 1990 Apr; 13(2): 155–66PubMed Dickel MJ, Mosko SS. Morbidity cut-offs for sleep apnea and periodic leg movements in predicting subjective complaints in seniors. Sleep 1990 Apr; 13(2): 155–66PubMed
41.
Zurück zum Zitat Sullivan CE, Issa FG, Berthon-Jones M, et al. Reversal of obstructive sleep apnea by continuous positive airway pressure applied through the nares. Lancet 1981 Apr; I(8225): 862–5CrossRef Sullivan CE, Issa FG, Berthon-Jones M, et al. Reversal of obstructive sleep apnea by continuous positive airway pressure applied through the nares. Lancet 1981 Apr; I(8225): 862–5CrossRef
42.
Zurück zum Zitat Strollo Jr PJ, Sanders MH, Atwood CW. Positive pressure therapy. Clin Chest Med 1998 Mar; 19(1): 55–68PubMedCrossRef Strollo Jr PJ, Sanders MH, Atwood CW. Positive pressure therapy. Clin Chest Med 1998 Mar; 19(1): 55–68PubMedCrossRef
43.
Zurück zum Zitat Aloia MS, Dio LD, Ilniczky N, et al. Improving compliance with nasal CPAP and vigilance in older adults with OSAHS. Sleep Breath 2001; 5(1): 13–22PubMedCrossRef Aloia MS, Dio LD, Ilniczky N, et al. Improving compliance with nasal CPAP and vigilance in older adults with OSAHS. Sleep Breath 2001; 5(1): 13–22PubMedCrossRef
44.
Zurück zum Zitat Douglas NJ, Engleman HM. CPAP therapy: outcomes and patient use. Thorax 1998 Oct; 53Suppl. 3: S47–8PubMed Douglas NJ, Engleman HM. CPAP therapy: outcomes and patient use. Thorax 1998 Oct; 53Suppl. 3: S47–8PubMed
45.
Zurück zum Zitat Shochat T, Cohen-Zion M, Ancoli-Israel S. The effects of CPAP treatment on cognitive function in dementia: a pilot study [abstract]. Sleep 2000; 23Suppl. 2: A218 Shochat T, Cohen-Zion M, Ancoli-Israel S. The effects of CPAP treatment on cognitive function in dementia: a pilot study [abstract]. Sleep 2000; 23Suppl. 2: A218
46.
Zurück zum Zitat Liu Y, Lowe AA, Fleetham JA, et al. Cephalometric and physiological predictors of the efficacy of an adjustable oral appliance for treating obstructive sleep apnea. Am J Orthod Dentofacial Orthop 2001 Dec; 120(6): 639–47PubMedCrossRef Liu Y, Lowe AA, Fleetham JA, et al. Cephalometric and physiological predictors of the efficacy of an adjustable oral appliance for treating obstructive sleep apnea. Am J Orthod Dentofacial Orthop 2001 Dec; 120(6): 639–47PubMedCrossRef
47.
Zurück zum Zitat Cartwright RD. Effect of sleep position on sleep apnea severity. Sleep 1984; 7(2): 110–4PubMed Cartwright RD. Effect of sleep position on sleep apnea severity. Sleep 1984; 7(2): 110–4PubMed
48.
Zurück zum Zitat Oksenberg A, Silverberg DS, Arons E, et al. Positional vs nonpositional obstructive sleep apnea patients: anthropomorphic, nocturnal polysomnographic, and multiple sleep latency test data. Chest 1997 Sep; 112(3): 629–39PubMedCrossRef Oksenberg A, Silverberg DS, Arons E, et al. Positional vs nonpositional obstructive sleep apnea patients: anthropomorphic, nocturnal polysomnographic, and multiple sleep latency test data. Chest 1997 Sep; 112(3): 629–39PubMedCrossRef
49.
Zurück zum Zitat Oksenberg A, Khamaysi I, Silverberg DS, et al. Association of body position with severity of apneic events in patients with severe nonpositional obstructive sleep apnea. Chest 2000 Oct; 118(4): 1018–24PubMedCrossRef Oksenberg A, Khamaysi I, Silverberg DS, et al. Association of body position with severity of apneic events in patients with severe nonpositional obstructive sleep apnea. Chest 2000 Oct; 118(4): 1018–24PubMedCrossRef
50.
Zurück zum Zitat Brownell LG, West P, Sweatman P, et al. Protriptyline in obstructive sleep apnea: a double blind trial. N Engl J Med 1982 Oct; 307(17): 1037–42PubMedCrossRef Brownell LG, West P, Sweatman P, et al. Protriptyline in obstructive sleep apnea: a double blind trial. N Engl J Med 1982 Oct; 307(17): 1037–42PubMedCrossRef
51.
Zurück zum Zitat Hanzel DA, Priora NG, Hudgel DW. Response of obstructive sleep apnea to fluoxetine and protriptyline. Chest 1991 Aug; 100(2): 416–21PubMedCrossRef Hanzel DA, Priora NG, Hudgel DW. Response of obstructive sleep apnea to fluoxetine and protriptyline. Chest 1991 Aug; 100(2): 416–21PubMedCrossRef
52.
Zurück zum Zitat Cook WR, Benich JJ, Wooten SA. Indices of severity of obstructive sleep apnea syndrome do not change during medroxyprogesterone acetate therapy. Chest 1989 Aug; 96(2): 262–6PubMedCrossRef Cook WR, Benich JJ, Wooten SA. Indices of severity of obstructive sleep apnea syndrome do not change during medroxyprogesterone acetate therapy. Chest 1989 Aug; 96(2): 262–6PubMedCrossRef
53.
Zurück zum Zitat Orr WC, Imes KN, Martin IJ. Progesterone therapy in obese patients with sleep apnea. Arch Intern Med 1979; 139: 109–11PubMedCrossRef Orr WC, Imes KN, Martin IJ. Progesterone therapy in obese patients with sleep apnea. Arch Intern Med 1979; 139: 109–11PubMedCrossRef
54.
Zurück zum Zitat Rajagopal KR, Abbrecht PH, Jabbari B. Effects of medroxyprogesterone acetate in obstructive sleep apnea. Chest 1986; 90: 815–21PubMedCrossRef Rajagopal KR, Abbrecht PH, Jabbari B. Effects of medroxyprogesterone acetate in obstructive sleep apnea. Chest 1986; 90: 815–21PubMedCrossRef
55.
Zurück zum Zitat Lin C, Tsan K, Chen P. The relationship between sleep apnea syndrome and hypothyroidism. Chest 1992 Dec; 102(6): 1663–7PubMedCrossRef Lin C, Tsan K, Chen P. The relationship between sleep apnea syndrome and hypothyroidism. Chest 1992 Dec; 102(6): 1663–7PubMedCrossRef
56.
Zurück zum Zitat Rajagopal KR, Abbrecht PH, Derderian SS, et al. Obstructive sleep apnea in hypothyroidism. Ann Intern Med 1984 Oct; 101(4): 491–4PubMed Rajagopal KR, Abbrecht PH, Derderian SS, et al. Obstructive sleep apnea in hypothyroidism. Ann Intern Med 1984 Oct; 101(4): 491–4PubMed
57.
Zurück zum Zitat Veasey SC, Fenik P, Panckeri K, et al. The effects of trazodone with l-tryptophan on sleep disordered breathing in the English bulldog. Am J Respir Crit Care Med 1999 Nov; 160(5): 1659–67PubMed Veasey SC, Fenik P, Panckeri K, et al. The effects of trazodone with l-tryptophan on sleep disordered breathing in the English bulldog. Am J Respir Crit Care Med 1999 Nov; 160(5): 1659–67PubMed
58.
Zurück zum Zitat Carley DW, Radulovacki M. Mirtazapine, a mixed profile serotonin agonist/antagonist, suppresses sleep apnea in the rat. Am J Respir Crit Care Med 1999 Dec; 160(6): 1824–9PubMed Carley DW, Radulovacki M. Mirtazapine, a mixed profile serotonin agonist/antagonist, suppresses sleep apnea in the rat. Am J Respir Crit Care Med 1999 Dec; 160(6): 1824–9PubMed
59.
Zurück zum Zitat Wetter DW, Young TB, Bidwell TR, et al. Smoking as a risk factor for sleep-disordered breathing. Arch Intern Med 1994 Oct; 154(19): 2219–24PubMedCrossRef Wetter DW, Young TB, Bidwell TR, et al. Smoking as a risk factor for sleep-disordered breathing. Arch Intern Med 1994 Oct; 154(19): 2219–24PubMedCrossRef
60.
Zurück zum Zitat Isono S, Shimada A, Tanaka A, et al. Efficacy of endoscopic static pressure/area assessment of the passive pharynx in predicting uvulopalatopharyngoplasty outcomes. Laryngoscope 1999; 109(5): 796–64CrossRef Isono S, Shimada A, Tanaka A, et al. Efficacy of endoscopic static pressure/area assessment of the passive pharynx in predicting uvulopalatopharyngoplasty outcomes. Laryngoscope 1999; 109(5): 796–64CrossRef
61.
Zurück zum Zitat Riley R, Powell N, Guilleminault C. Current surgical concepts for treating obstructive sleep apnea syndrome. J Oral Maxil-lofac Surg 1987; 43: 149–57CrossRef Riley R, Powell N, Guilleminault C. Current surgical concepts for treating obstructive sleep apnea syndrome. J Oral Maxil-lofac Surg 1987; 43: 149–57CrossRef
62.
Zurück zum Zitat Pillar G, Schnall R, Lavie P. Sleep apnea and surgery. Curr Opin Anesthesiol 1996; 9: 536–41 Pillar G, Schnall R, Lavie P. Sleep apnea and surgery. Curr Opin Anesthesiol 1996; 9: 536–41
63.
Zurück zum Zitat Sher AE, Schechtman KB, Piccirillo JF. The efficacy of surgical modifications of the upper airway in adults with obstructive sleep apnea syndrome. Sleep 1996; 19: 156–77PubMed Sher AE, Schechtman KB, Piccirillo JF. The efficacy of surgical modifications of the upper airway in adults with obstructive sleep apnea syndrome. Sleep 1996; 19: 156–77PubMed
64.
Zurück zum Zitat Riley RW, Powell NB, Li KK, et al. Surgical therapy for obstructive sleep apnea-hypopnea syndrome. In: Kryger MH, Roth T, Dement WC, editors. Principles and practice of sleep medicine. 3rd ed. Philadelphia (PA): WB Saunders, 2000: 913–28 Riley RW, Powell NB, Li KK, et al. Surgical therapy for obstructive sleep apnea-hypopnea syndrome. In: Kryger MH, Roth T, Dement WC, editors. Principles and practice of sleep medicine. 3rd ed. Philadelphia (PA): WB Saunders, 2000: 913–28
65.
Zurück zum Zitat Powell NB, Riley RW, Troell RJ, et al. Radiofrequency volumetric tissue reduction of the palate in subjects. Chest 1998 May; 113(5): 1163–74PubMedCrossRef Powell NB, Riley RW, Troell RJ, et al. Radiofrequency volumetric tissue reduction of the palate in subjects. Chest 1998 May; 113(5): 1163–74PubMedCrossRef
Metadaten
Titel
Sleep Apnoea In The Older Adult
Pathophysiology, Epidemiology, Consequences And Management
verfasst von
Dr Tamar Shochat
Giora Pillar
Publikationsdatum
01.07.2003
Verlag
Springer International Publishing
Erschienen in
Drugs & Aging / Ausgabe 8/2003
Print ISSN: 1170-229X
Elektronische ISSN: 1179-1969
DOI
https://doi.org/10.2165/00002512-200320080-00001

Weitere Artikel der Ausgabe 8/2003

Drugs & Aging 8/2003 Zur Ausgabe

Adis Drug Evaluation

Latanoprost

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.