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Drugs
Erschienen in: Drugs 3/2006

01.02.2006 | Adis Drug Profile

0.4% Nitroglycerin Ointment

In the Treatment of Chronic Anal Fissure Pain

verfasst von: Caroline Fenton, Keri Wellington, Stephanie E. Easthope

Erschienen in: Drugs | Ausgabe 3/2006

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Abstract

▴ 0.4% Nitroglycerin ointment is an intra-anal formulation of nitroglycerin (glyceryl trinitrate) indicated for the treatment of chronic anal fissure pain.
▴ Nitroglycerin is a nitric oxide (NO) donor, which reduces the increased anal canal pressure caused by a hypertonic internal anal sphincter, improving anodermal blood flow.
▴ A twice-daily 375mg application of 0.4% nitroglycerin ointment, delivering a daily nitroglycerin dose of 3mg, significantly increased the rate of decrease in mean visual-analogue-scale pain scores, recorded daily, versus placebo (actual vehicle) over the first 3 and 8 weeks of treatment in patients with chronic anal fissure pain participating in randomised double-blind trials.
▴ Most recipients of 0.4% nitroglycerin ointment experienced headache, which was transient but severe in 20–25% of patients in randomised double-blind trials; however, compliance was generally good with few study withdrawals.
Fußnoten
1
The use of trade names is for product identification purposes only and does not imply endorsement.
 
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Metadaten
Titel
0.4% Nitroglycerin Ointment
In the Treatment of Chronic Anal Fissure Pain
verfasst von
Caroline Fenton
Keri Wellington
Stephanie E. Easthope
Publikationsdatum
01.02.2006
Verlag
Springer International Publishing
Erschienen in
Drugs / Ausgabe 3/2006
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI
https://doi.org/10.2165/00003495-200666030-00006

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0.4% Nitroglycerin Ointment in the Treatment of Chronic Anal Fissure Pain