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01.02.2007 | Review Article

The Epidemiology, Pathogenesis and Treatment of Pseudomonas aeruginosa Infections

verfasst von: James A. Driscoll, Steven L. Brody, Dr Marin H. Kollef

Erschienen in: Drugs | Ausgabe 3/2007

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Abstract

Pseudomonas aeruginosa is an important bacterial pathogen, particularly as a cause of infections in hospitalised patients, immunocompromised hosts and patients with cystic fibrosis. Surveillance of nosocomial P. aeruginosa infections has revealed trends of increasing antimicrobial resistance, including carbapenem resistance and multidrug resistance. Mechanisms of antimicrobial resistance include multidrug efflux pumps, β-lactamases and downregulation of outer membrane porins. Mechanisms of virulence include secreted toxins and the ability to form biofilms. The effective treatment of infections caused by P. aeruginosa includes prevention when possible, source control measures as necessary and prompt administration of appropriate antibacterial agents. Antibacterial de-escalation should be pursued in patients with an appropriate clinical response, especially when antibacterial susceptibilities are known. Multidrug-resistant P. aeruginosa may require treatment with less commonly used antibacterials (e.g. colistin), but newer anti-pseudomonal antibacterials are expected to be available in the near future.

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Titel: The Epidemiology, Pathogenesis and Treatment of Pseudomonas aeruginosa Infections
verfasst von: James A. Driscoll
Steven L. Brody
Dr Marin H. Kollef
Publikationsdatum: 01.02.2007
Verlag: Springer International Publishing
Erschienen in: Drugs / Ausgabe 3/2007
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI: https://doi.org/10.2165/00003495-200767030-00003

Springer Medizin

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Monoclonal Antibodies in the Treatment of Non-Hodgkin’s Lymphoma

Antianginal Efficacy and Safety of Ivabradine Compared with Amlodipine in Patients with Stable Effort Angina Pectoris

Sorafenib