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01.10.2003 | Review Article

Popular Sports Supplements and Ergogenic Aids

Erschienen in: Sports Medicine | Ausgabe 12/2003

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Abstract

This article reviews the evidence-based ergogenic potential and adverse effects of 14 of the most common products in use by recreational and elite athletes today. Both legal and prohibited products are discussed. This is an aggressively marketed and controversial area of sports medicine worldwide. It is therefore prudent for the clinician to be well versed in the more popular supplements and drugs reputed to be ergogenic in order to distinguish fact from fiction.

Antioxidants, proteins and amino acids are essential components of diet, but additional oral supplementation does not increase endurance or strength. Caffeine is ergogenic in certain aerobic activities. Creatine is ergogenic in repetitive anaerobic cycling sprints but not running or swimming. Ephedrine and pseudoephedrine may be ergogenic but have detrimental cardiovascular effects. Erythropoietin is ergogenic but increases the risk of thromboembolic events. β-Hydroxy-β-methylbutyrate has ergogenic potential in untrained individuals, but studies are needed on trained individuals. Human growth hormone and insulin growth factor-I decrease body fat and may increase lean muscle mass when given subcutaneously. Pyruvate is not ergogenic. The androgenic precursors androstenedione and dehydroepiandrosterone have not been shown to increase any parameters of strength and have potentially significant adverse effects. Anabolic steroids increase protein synthesis and muscle mass but with many adverse effects, some irreversible. Supplement claims on labels of product content and efficacy can be inaccurate and misleading.

The use of tradenames is for product identification purposes only and does not imply endorsement.

Abbott A. What price the Olympian ideal? Nature 2000; 407: 124–7PubMedCrossRef

Sheppard HL, Raichada SM, Kouri KM, et al. Use of creatine and other supplements by members of civilian and military health clubs: a cross-sectional survey. Int J Sport Nutr Exerc Metab 2000; 10(3): 245–59PubMed

Juhn MS, O’Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999; 99(5): 593–5PubMedCrossRef

United States of America 103rd Congress. Public law 103-417. Dietary Supplements Health and Education Act of 1994 (21USC 3419 (r) (6)), 1994 [online]. Available from URL: http://www.fda.gov/opacom/laws/dshea.html [Accessed 2003 Aug 1]

Clarkson PM, Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr 2000; 72 (2 Suppl.): 637S–46SPubMed

Sen CK. Antioxidants in exercise nutrition. Sports Med 2001; 31(13): 891–908PubMedCrossRef

American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada. Joint position statement: nutrition and athletic performance. Med Sci Sports Exerc 2000; 32(12): 2130–45CrossRef

Nielsen AN, Mizuno M, Ratkevicius A, et al. No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue. Int J Sports Med 1999; 20(3): 154–8PubMed

Buchman AL, Killip D, Ou CN, et al. Short-term vitamin E supplementation before marathon running: a placebo-controlled trial. Nutrition 1999; 15(4): 278–83PubMedCrossRef

10.

Weston SB, Zhou S, Weatherby RP, et al. Does exogenous coenzyme Q10 affect aerobic capacity in endurance athletes? Int J Sport Nutr 1997; 7(3): 197–206PubMed

11.

Thompson D, Williams C, Kingsley M, et al. Muscle soreness and damage parameters after prolonged intermittent shuttle-running following acute vitamin C supplementation. Int J Sports Med 2001; 22(1): 68–75PubMedCrossRef

12.

Schroder H, Navarro E, Tramullas A, et al. Nutrition antioxidant status and oxidative stress in professional basketball players: effects of a three compound antioxidative supplement. Int J Sports Med 2000; 21(2): 146–50PubMedCrossRef

13.

Santos-Silva A, Rebelo MI, Castro EM, et al. Leukocyte activation, erythrocyte damage, lipid profile and oxidative stress imposed by high competition physical exercise in adolescents. Clin Chim Acta 2001; 306(1–2): 119–26PubMedCrossRef

14.

Fredholm BB, Battig K, Holmen J, et al. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 1999 Mar; 51(1): 83–133PubMed

15.

Lindskog M, Svenningsson P, Pozzi L, et al. Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature 2002 Aug 15; 418(6899): 774–8PubMedCrossRef

16.

Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med 2001; 31(11): 785–807PubMedCrossRef

17.

MacIntosh BR, Wright BM. Caffeine ingestion and performance of a 1500-metre swim. Can J Appl Physiol 1995; 20(2): 168–77PubMedCrossRef

18.

Kovacs EM, Stegen JHCH, Brouns F. Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance. J Appl Physiol 1998; 85(2): 709–15PubMed

19.

Greer F, Friars D, Graham TE. Comparison of caffeine and theophylline ingestion: exercise metabolism and endurance. J Appl Physiol 2000; 89(5): 1837–44PubMed

20.

Pasman WJ, van Baak MA, Jeukendrup AE, et al. The effect of different dosages of caffeine on endurance performance time. Int J Sports Med 1995; 16(4): 225–30PubMedCrossRef

21.

Bruce CR, Anderson ME, Fraser SF, et al. Enhancement of 2000m rowing performance after caffeine ingestion. Med Sci Sports Exerc 2000; 32(11): 1958–63PubMedCrossRef

22.

Greer F, McLean C, Graham T. Caffeine, performance, and metabolism during repeated Wingate exercise tests. J Appl Physiol 1998; 85: 1502–8PubMed

23.

Collomp K, Ahmaidi S, Chatard JC, et al. Benefits of caffeine ingestion on sprint performance in trained and untrained swimmers. Eur J Appl Physiol Occup Physiol 1992; 64(4): 377–80PubMedCrossRef

24.

Paton CD, Hopkins WG, Vollebregt L. Little effect of caffeine ingestion on repeated sprints in team-sport athletes. Med Sci Sports Exerc 2001; 33(5): 822–5PubMed

25.

Wemple RD, Lamb DR, McKeever KH. Caffeine vs caffeine-free sports drinks: effects on urine production at rest and during prolonged exercise. Int J Sports Med 1997; 18(1): 40–6PubMedCrossRef

26.

Harland BF. Caffeine and nutrition. Nutrition 2000; 16(7–8): 522–6PubMedCrossRef

27.

Mesa JL, Ruiz JR, Gonzalez-Gross MM, et al. Oral creatine supplementation and skeletal muscle metabolism in physical exercise. Sports Med 2002; 32(14): 903–44PubMedCrossRef

28.

Juhn MS, Tarnopolsky M. Oral creatine supplementation and athletic performance: a critical review. Clin J Sport Med 1998; 8(4): 286–97PubMedCrossRef

29.

Terjung RL, Clarkson P, Eichner ER, et al. American College of Sports Medicine roundtable: the physiological and health effects of oral creatine supplementation. Med Sci Sports Exerc 2000; 32(3): 706–17PubMedCrossRef

30.

Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996; 81(1): 232–7PubMed

31.

Haussinger D, Roth E, Lang F, et al. Cellular hydration state: an important determinant of protein catabolism in health and disease. Lancet 1993; 341: 1330–2PubMedCrossRef

32.

Parise G, Mihic S, MacLennan D, et al. Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis. J Appl Physiol 2001; 91(3): 1041–7PubMed

33.

Louis M, Poortmans JR, Francaux M, et al. Creatine supplementation does not further stimulate human myofibrillar or sarcoplasmic protein synthesis after resistance exercise. Am J Physiol Endocrinol Metab. Epub 2003 Jun 24

34.

Smith J, Dahm DL. Creatine use among a select population of high school athletes. Mayo Clin Proc 2000; 75(12): 1257–63PubMedCrossRef

35.

LaBotz M, Smith BW. Creatine supplement use in an NCAA division I athletic program. Clin J Sport Med 1999; 9(3): 167–9PubMedCrossRef

36.

Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996 Nov; 271 (5 Pt 1): E821–6PubMed

37.

Benzi G, Ceci A. Creatine as nutritional supplementation and medicinal product. J Sports Med Phys Fitness 2001; 41(1): 1–10PubMed

38.

Graham AS, Hatton RC. Creatine: a review of efficacy and safety. J Am Pharm Assoc 1999; 39(6): 803–10

39.

Tarnopolsky MA, MacLennan DP. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab 2000; 10(4): 452–63PubMed

40.

Bemben MG, Tuttle TD, Bemben DA, et al. Effects of creatine supplementation on isometric force-time curve characteristics. Med Sci Sports Exerc 2001; 33(11): 1876–81PubMedCrossRef

41.

Op’t Eijnde BO, Vergauwen L, Hespel P. Creatine loading does not impact on stroke performance in tennis. Int J Sports Med 2001; 22: 76–80CrossRef

42.

Hamilton KL, Meyers MC, Skelly WA, et al. Oral creatine supplementation and upper extremity anaerobic response in females. Int J Sports Nutr 2000; 10: 277–89

43.

Balsom PD, Harridge SD, Soderlund K, et al. Creatine supplementation per se does not enhance endurance exercise performance. Acta Physiol Scand 1993; 149(4): 521–3PubMedCrossRef

44.

Mujika I, Padilla S, Ibanez J, et al. Creatine supplementation and sprint performance in soccer players. Med Sci Sports Exerc 2000; 32(2): 518–25PubMedCrossRef

45.

Cox G, Mujika I, Tumilty D, et al. Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. Int J Sport Nutr Exerc Metab 2002 Mar; 12(1): 33–46PubMed

46.

Mujika I, Chatard JC, Lacoste L, et al. Creatine supplementation does not improve sprint performance in competitive swimmers. Med Sci Sports Exerc 1996; 28: 11: 1435–41PubMedCrossRef

47.

Juhn MS, Tarnopolsky M. Potential side effects of oral creatine supplementation: a critical review. Clin J Sport Med 1998; 8(4): 298–304PubMedCrossRef

48.

Schroeder C, Potteiger J, Randall J, et al. The effects of creatine dietary supplementation on anterior compartment pressure in the lower leg during rest and following exercise. Clin J Sport Med 2001; 11(2): 87–95PubMedCrossRef

49.

McGuine TA, Sullivan JC, Bernardt DT. Creatine supplementation in high school football players. Clin J Sport Med 2001; 11(4): 247–53PubMedCrossRef

50.

Robinson SJ. Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J Am Board Fam Pract 2000; 13(2): 134–7PubMed

51.

Edmunds JW, Jayapalan S, DiMarco NM, et al. Creatine supplementation increases renal disease progression in Han: SPRD-cy rats. Am J Kidney Dis 2001; 37(1): 73–8PubMedCrossRef

52.

Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999; 340(10): 814–5PubMedCrossRef

53.

Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998; 351(9111): 1252–3PubMedCrossRef

54.

Dechent P, Pouwels PJ, Wilken B, et al. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am J Physiol 1999; 277 (3 Pt 2): R698–704PubMed

55.

Ipsiroglu OS, Stromberger C, Ilas J, et al. Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species. Life Sci 2001; 69(15): 1805–15PubMedCrossRef

56.

Bell DG, McLellan TM, Sabiston CM. Effect of ingesting caffeine and ephedrine on 10-km run performance. Med Sci Sports Exerc 2002 Feb; 34(2): 344–9PubMedCrossRef

57.

Hoffman BB, Lefkowitz RJ. Catecholamines and sympathomimetic drugs: In: Gillman AG, Rall TW, Nies AS, et al., editors. Goodman and Gillman’s the pharmacological basis of therapeutics. New York: Pergamon Press, 1990: 187–220

58.

Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001 Aug; 33(8): 1399–403PubMedCrossRef

59.

Gillies H, Derman WE, Noakes TD, et al. Pseudoephedrine is without ergogenic effects during prolonged exercise. J Appl Physiol 1996 Dec; 81(6): 2611–7PubMed

60.

Chu KS, Doherty TJ, Parise G, et al. A moderate dose of pseudoephedrine does not alter muscle contraction strength or anaerobic power. Clin J Sport Med 2002 Nov; 12(6): 387–90PubMedCrossRef

61.

Gill ND, Shield A, Blazevich AJ, et al. Muscular and cardiorespiratory effects of pseudoephedrine in human athletes. Br J Clin Pharmacol 2000 Sep; 50(3): 205–13PubMedCrossRef

62.

Swain RA, Harsha DM, Baenziger J, et al. Do pseudoephedrine or phenylpropanolamine improve maximum oxygen uptake and time to exhaustion? Clin J Sport Med 1997; 7(3): 168–73PubMedCrossRef

63.

Chester N, Reilly T, Mottram DR. Physiological, subjective and performance effects of pseudoephedrine and phenylpropanolamine during endurance running exercise. Int J Sports Med 2003; 24(1): 3–8PubMedCrossRef

64.

Thomson PR, editor. Physicians desk reference for nonprescription drugs and dietary supplements. 24th ed. Montvale (NJ): Thomson Healthcare, 2003: 521–730

65.

Meadows M. Public health officials caution against ephedra use. Health officials caution consumers against using dietary supplements containing ephedra. The stimulant can have dangerous effects on the nervous system and heart. FDA Consum 2003; 37(3): 8–9PubMed

66.

Bent S, Tiedt TN, Odden MC, et al. The relative safety of ephedra compared with other herbal products. Ann Intern Med 2003; 138(6): 468–71PubMed

67.

Morgenstern LB, Viscoli CM, Kernan WN, et al. Use of ephedra-containing products and risk for hemorrhagic stroke. Neurology 2003; 60(1): 132–5PubMedCrossRef

68.

Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000 Dec 21; 343(25): 1833–8PubMedCrossRef

69.

Choi D, Kim M, Park J. Erythropoietin: physico- and biochemical analysis. J Chromatogr B Biomed Appl 1996; 687(1): 189–99PubMedCrossRef

70.

Celsing F, Svedenhag J, Pihlstedt P, et al. Effects of anaemia and stepwise-induced polycythaemia on maximal aerobic power in individuals with high and low haemoglobin concentrations. Acta Physiol Scand 1987; 129(1): 47–54PubMedCrossRef

71.

Aranesp prescribing information 2001 [online]. Thousand Oaks (CA): Amgen Inc. Available from URL: http://www.aranesp.com/professional/prescribing-info.jsp [Accessed 2003 Aug 1]

72.

Audran M, Gareau R, Matecki S, et al. Effects of erythropoietin administration in training athletes and possible indirect detection in doping control. Med Sci Sports Exerc 1999; 31(5): 639–45PubMedCrossRef

73.

Ekblom BT. Blood boosting and sport. Baillieres Best Pract Res Clin Endocrinol Metab 2000; 14(1): 89–98PubMedCrossRef

74.

Ekblom B, Berglund B. Effect of erythropoietin administration on maximal aerobic power. Scand J Med Sci Sports 1991; 1: 88–93CrossRef

75.

Singbart G. Adverse effects of erythropoietin in long-term and in acute/short-term treatment. Clin Invest 1994; 72: S36–43

76.

Sunder-Plassmann G, Horl WH. Effect of erythropoietin on cardiovascular diseases. Am J Kidney Dis 2001; 38 (4 Suppl. 1): S20–5PubMedCrossRef

77.

Parisotto R, Gore CJ, Emslie KR, et al. A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes. Haematologica 2000; 85(6): 564–72PubMed

78.

Harrison MH. Effects on thermal stress and exercise on blood volume in humans. Physiol Rev1985; 65(1): 149–209PubMed

79.

Vasquez R, Villena M. Normal hematological values for healthy persons living at 4000 meters in Bolivia. High Alt Med Biol 2001; 2(3): 361–7PubMedCrossRef

80.

Parisotto R, Wu M, Ashenden MJ, et al. Detection of recombinant human erythropoietin abuse in athletes utilizing markers of altered erythropoiesis. Haematologica 2001; 86(2): 128–37PubMed

81.

Nissen SL, Abumrad NN. Nutritional role of the leucine metabolite β-hydroxy-β-methylbutyrate (HMB). Nutr Biochem 1997; 8: 300–11CrossRef

82.

Slater GJ, Jenkins D. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength. Sports Med 2000; 30(2): 105–16PubMedCrossRef

83.

Knitter AE, Panton L, Rathmacher JA, et al. Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run. J Appl Physiol 2000; 89(4): 1340–4PubMed

84.

Gallagher PM, Carrithers JA, Godard MP, et al. Beta-hydroxy-beta-methylbutyrate ingestion. Part I: effects on strength and fat free mass. Med Sci Sports Exerc 2000; 32(12): 2109–15PubMedCrossRef

85.

Panton LB, Rathmacher JA, Baier MS, et al. Nutritional supplementation of the leucine metabolit β-hydroxy-β-methylbutyrate (HMB) during resistance training. Nutrition 2000; 16: 734–9PubMedCrossRef

86.

Jowko E, Ostaszewski P, Jank M, et al. Creatine and betahydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program. Nutrition 2001; 17(7–8): 558–66PubMedCrossRef

87.

Slater G, Jenkins D, Logan P, et al. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men. Int J Sport Nutr Exerc Metab 2001; 11(3): 384–96PubMed

88.

Phillips SM, Tipton KD, Ferrando AA, et al. Resistance training reduces the acute exercise-induced increase in muscle protein turnover. Am J Physiol 1999; 276 (1 Pt 1): E118–24PubMed

89.

Gallagher PM, Carrithers JA, Godard MP, et al. Beta-hydroxy-beta-methylbutyrate ingestion. Part II: effects on hematology, hepatic and renal function. Med Sci Sports Exerc 2000; 32(12): 2116–9PubMedCrossRef

90.

Nissen S, Sharp RL, Panton L, et al. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors. J Nutr 2000; 130(8): 1937–45PubMed

91.

Le Roith D. Insulin-like growth factors. N Engl J Med 1997; 336(9): 633–40PubMedCrossRef

92.

Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990; 323(1): 1–6PubMedCrossRef

93.

De Palo EF, Gatti R, Lancerin F, et al. Correlations of growth hormone (GH) and insulin-like growth factor 1 (IGF-1): effects of exercise and abuse by athletes. Clin Chim Acta 2001; 305(1–2): 1–17PubMedCrossRef

94.

Jenkins PJ. Growth hormone and exercise: physiology, use and abuse. Growth Horm IGF Res 2001; 11Suppl. A: S71–7PubMedCrossRef

95.

Sonksen PH. Insulin, growth hormone and sport. J Endocrinol 2001; 170(1): 13–25PubMedCrossRef

96.

Frisch H. Growth hormone and body composition in athletes. J Endocrinol Invest 1999; 22 (5 Suppl.): 106–9PubMed

97.

Johannsson G, Jorgensen JOL. Safety aspects of growth hormone replacement in adults. Growth Horm IGF Res 2001; 11(2): 59–71PubMedCrossRef

98.

Fryburg DA, Jahn LA, Hill SA, et al. Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest 1995; 96(4): 1722–9PubMedCrossRef

99.

Yarasheski KE, Zachwieja JJ, Campbell JA, et al. Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol 1995; 268 (2 Pt 1): E268–76PubMed

100.

Grimberg A, Cohen P. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol 2000; 183(1): 1–9PubMedCrossRef

101.

Lemon PW. Beyond the zone: protein needs of active individuals. J Am Coll Nutr 2000; 19 (5 Suppl.): 513S–21SPubMed

102.

Williams MH. Facts and fallacies of purported ergogenic amino acid supplements. Clin Sports Med 1999; 18(3): 633–49PubMedCrossRef

103.

Tarnopolsky MA, Atkinson SA, MacDougall JD, et al. Evaluation of protein requirements for trained strength athletes. J Appl Physiol 1992; 73(5): 1986–95PubMed

104.

Lemon PW, Tarnopolsky MA, MacDougall JD, et al. Protein requirements and muscle mass/strength changes during intensive training in novice bodybuilders. J Appl Physiol 1992; 73(2): 767–75PubMed

105.

Williams AG, van den Oord M, Sharma A, et al. Is glucose/ amino acid supplementation after exercise an aid to strength training? Br J Sports Med 2001; 35(2): 109–13PubMedCrossRef

106.

Jentjens RL, van Loon LJ, Mann CH, et al. Addition of protein and amino acids to carbohydrates does not enhance post-exercise muscle glycogen synthesis. J Appl Physiol 2001; 91(2): 839–46PubMed

107.

Davis JM, Welsh RS, De Volve KL, et al. Effects of branched-chain amino acids and carbohydrate on fatigue during intermittent, high-intensity running. Int J Sports Med 1999; 20(5): 309–14PubMedCrossRef

108.

Coombes JS, McNaughton LR. Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise. J Sports Med Phys Fitness 2000; 40(3): 240–6PubMed

109.

Mourier A, Bigard AX, de Kerviler E, et al. Combined effects of caloric restriction and branched-chain amino acid supplementation on body composition and exercise performance in elite wrestlers. Int J Sports Med 1997; 18(1): 47–55PubMedCrossRef

110.

Wagenmakers AJ. Amino acid supplements to improve athletic performance. Curr Opin Clin Nutr Metab Care 1999; 2(6): 539–44PubMedCrossRef

111.

Stanko RT, Robertson RJ, Galbreath RW, et al. Enhanced leg exercise endurance with a high-carbohydrate diet and dihydroxyacetone and pyruvate. J Appl Physiol 1990; 69(5): 1651–6PubMed

112.

Stanko RT, Robertson RJ, Spina RJ, et al. Enhancement of arm exercise endurance capacity with dihydroxyacetone and pyruvate. J Appl Physiol 1990; 68(1): 119–24PubMed

113.

Morrison MA, Spriet LL, Dyck DJ. Pyruvate ingestion for 7 days does not improve aerobic performance in well-trained individuals. J Appl Physiol 2000; 89(2): 549–56PubMed

114.

Sukala WR. Pyruvate: beyond the marketing hype. Int J Sport Nutr 1998; 8(3): 241–9PubMed

115.

Earnest CP. Dietary androgen supplements: separating substance from hype. Phys Sports Med 2001; 29(5): 63–79

116.

Leder BZ, Catlin DH, Longcope C, et al. Metabolism of orally administered androstenedione in young men. J Clin Endocrinol Metab 2001; 86(8): 3654–8PubMedCrossRef

117.

Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000; 283(6): 779–82PubMedCrossRef

118.

King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial. JAMA 1999; 281(21): 2020–8PubMedCrossRef

119.

Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000; 160(20): 3093–104PubMedCrossRef

120.

Rasmussen BB, Volpi E, Gore DC, et al. Androstenedione does not stimulate muscle protein anabolism in young healthy men. J Clin Endocrinol Metab 2000; 85(1): 55–9PubMedCrossRef

121.

Catlin DH, Leder BZ, Ahrens B, et al. Trace contamination of over-the-counter androstenedione and positive urine test results for a nandrolone metabolite. JAMA 2000; 284(20): 2618–21PubMedCrossRef

122.

Brown GA, Vukovich MD, Reifenrath TA, et al. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 2000; 10(3): 340–59PubMed

123.

Brown GA, Vukovich MD, Sharp RL, et al. Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men. J Appl Physiol 1999; 87(6): 2274–83PubMed

124.

Abramowicz M, editor. Dehydroepiandrosterone (DHEA). Med Lett Drugs Ther 1996; 38(985): 91–2

125.

Shahidi NT. A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids. Clin Ther 2001; 23(9): 1355–90PubMedCrossRef

126.

Bahrke MS, Yesalis CE, Kopstein AN, et al. Risk factors associated with anabolic-androgenic steroid use among adolescents. Sports Med 2000; 29(6): 397–405PubMedCrossRef

127.

Kutscher EC, Lund BC, Perry PJ. Anabolic steroids: a review for the clinician. Sports Med 2002; 32(5): 285–96PubMedCrossRef

128.

Blue JG, Lombardo JA. Steroids and steroid-like compounds. Clin Sports Med 1999; 18(3): 667–89PubMedCrossRef

129.

Griggs RC, Kingston W, Jozefowicz RF, et al. Effect of testosterone on muscle mass and muscle protein synthesis. J Appl Physiol 1989; 66(1): 498–503PubMed

130.

Tamaki T, Uchiyama S, Uchiyama Y, et al. Anabolic steroids increase exercise tolerance. Am J Physiol Endocrinol Metab 2001; 280(6): E973–81PubMed

131.

Fenichel GM, Griggs RC, Kissel J, et al. A randomized efficacy and safety trial of oxandrolone in the treatment of Duchenne dystrophy. Neurology 2001 Apr 24; 56(8): 1075–9PubMedCrossRef

132.

Dickerman RD, Pertusi RM, Zachariah NY, et al. Anabolic steroid-induced hepatotoxicity: is it overstated? Clin J Sport Med 1999; 9(1): 34–9PubMedCrossRef

133.

Torres-Calleja J, Gonzalez-Unzaga M, DeCelis-Carrillo R, et al. Effect of androgenic anabolic steroids on sperm quality and serum hormone levels in adult male bodybuilders. Life Sci 2001; 68(15): 1769–74PubMedCrossRef

134.

Kindlundh AM, Hagekull B, Isacson DG, et al. Adolescent use of anabolic-androgenic steroids and relations to self-reports of social, personality and health aspects. Eur J Public Health 2001; 11(3): 322–8PubMedCrossRef

135.

Nilsson S, Baigi A, Marklund B, et al. Trends in the misuse of androgenic anabolic steroids among boys 16–17 years old in a primary health care area in Sweden. Scand J Prim Health Care 2001; 19(3): 181–2PubMedCrossRef

136.

Green GA, Catlin DH, Starcevic B. Analysis of over-the-counter dietary supplements. Clin J Sport Med 2001; 11(4): 254–9PubMedCrossRef

Titel: Popular Sports Supplements and Ergogenic Aids
Publikationsdatum: 01.10.2003
Erschienen in: Sports Medicine / Ausgabe 12/2003
Print ISSN: 0112-1642
Elektronische ISSN: 1179-2035
DOI: https://doi.org/10.2165/00007256-200333120-00004

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Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update Orthopädie und Unfallchirurgie

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