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Erschienen in: PharmacoEconomics 6/2008

01.06.2008 | Leading Article

Economic Burden of Heart Failure in the Elderly

verfasst von: Dr Lawrence Liao, Larry A. Allen, David J. Whellan

Erschienen in: PharmacoEconomics | Ausgabe 6/2008

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Abstract

Heart failure (HF) ranks among the most costly chronic diseases in developed countries. At present these countries devote 1–2% of all healthcare expenditures towards HF. In the US, these costs are estimated at $US30.2 billion for 2007. The burden of HF is greatest among the elderly, with 80% of HF hospitalizations and 90% of HF-related deaths in this cohort. As a result, approximately three-quarters of the resources for HF care are consumed by elderly patients. As demographic shifts increase the number of elderly individuals in both developed and developing nations, the resources devoted to HF care will likely further increase.
Hospitalization accounts for roughly two-thirds of HF costs, but procedures, outpatient visits and medications also consume significant financial resources. HF also adversely impacts patient quality of life, and these relevant effects may not be captured in pure cost analyses. The cost effectiveness of several pharmacological interventions has been explored. In general, neurohormonal antagonists used for outpatient treatment of chronic HF are relatively cost effective, in part by reducing hospitalizations.
Because HF poses such an enormous financial burden, efficient resource allocation for its management is a major societal and governmental challenge. In order to make informed decisions and allocate resources for HF care rationally, detailed data regarding costs and resource use will be essential. Further studies are needed to examine the impact of pharmacological and non-pharmacological interventions on costs and resource use in elderly individuals with HF.
Literatur
1.
Zurück zum Zitat Mosterd A, Hoes AW, de Bruyne MC, et al. Prevalence of heart failure and left ventricular dysfunction in the general population: The Rotterdam Study. Eur Heart J 1999; 20: 447–455PubMedCrossRef Mosterd A, Hoes AW, de Bruyne MC, et al. Prevalence of heart failure and left ventricular dysfunction in the general population: The Rotterdam Study. Eur Heart J 1999; 20: 447–455PubMedCrossRef
2.
Zurück zum Zitat Redfield MM, Jacobsen SJ, Burnett Jr JC, et al. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 2003; 289: 194–202PubMedCrossRef Redfield MM, Jacobsen SJ, Burnett Jr JC, et al. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 2003; 289: 194–202PubMedCrossRef
3.
Zurück zum Zitat Rosamond W, Flegal K, Friday G, et al. Heart disease and stroke statistics: 2007 update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2007; 115: e69–e171PubMedCrossRef Rosamond W, Flegal K, Friday G, et al. Heart disease and stroke statistics: 2007 update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2007; 115: e69–e171PubMedCrossRef
4.
Zurück zum Zitat Schulman KA, Mark DB, Califf RM. Outcomes and costs within a disease management program for advanced congestive heart failure. Am Heart J 1998; 135: S285–S292PubMedCrossRef Schulman KA, Mark DB, Califf RM. Outcomes and costs within a disease management program for advanced congestive heart failure. Am Heart J 1998; 135: S285–S292PubMedCrossRef
5.
Zurück zum Zitat Haldeman GA, Croft JB, Giles WH, et al. Hospitalization of patients with heart failure: national hospital discharge survey, 1985 to 1995. Am Heart J 1999; 137: 352–360PubMedCrossRef Haldeman GA, Croft JB, Giles WH, et al. Hospitalization of patients with heart failure: national hospital discharge survey, 1985 to 1995. Am Heart J 1999; 137: 352–360PubMedCrossRef
6.
Zurück zum Zitat Croft JB, Giles WH, Pollard RA, et al. National trends in the initial hospitalization for heart failure. J Am Geriatr Soc 1997; 45: 270–275PubMed Croft JB, Giles WH, Pollard RA, et al. National trends in the initial hospitalization for heart failure. J Am Geriatr Soc 1997; 45: 270–275PubMed
7.
Zurück zum Zitat Ryden-Bergsten T, Adersson F. Health care costs of heart failure in Sweden. J Intern Med 1999; 246: 275–284PubMedCrossRef Ryden-Bergsten T, Adersson F. Health care costs of heart failure in Sweden. J Intern Med 1999; 246: 275–284PubMedCrossRef
8.
Zurück zum Zitat Lee WC, Chavez YE, Baker T, et al. Economic burden of heart failure: a summary of recent literature. Heart Lung 2004; 33: 362–371PubMedCrossRef Lee WC, Chavez YE, Baker T, et al. Economic burden of heart failure: a summary of recent literature. Heart Lung 2004; 33: 362–371PubMedCrossRef
9.
Zurück zum Zitat Berry C, Murdoch DR, McMurray JJV. Economics of chronic heart failure. Euro J Heart Fail 2001; 3: 283–291CrossRef Berry C, Murdoch DR, McMurray JJV. Economics of chronic heart failure. Euro J Heart Fail 2001; 3: 283–291CrossRef
10.
Zurück zum Zitat Kitzman D, Gardin J, Gottdiener JS, et al. Importance of heart failure with preserved systolic function in patients ≥65 years of age. Am J Cardiol 2001; 87: 413–419PubMedCrossRef Kitzman D, Gardin J, Gottdiener JS, et al. Importance of heart failure with preserved systolic function in patients ≥65 years of age. Am J Cardiol 2001; 87: 413–419PubMedCrossRef
11.
Zurück zum Zitat Hogg K, Swedberg K, McMurray J. Heart failure with preserved left ventricular systolic function. J Am Coll Cardiol 2004; 43: 317–327PubMedCrossRef Hogg K, Swedberg K, McMurray J. Heart failure with preserved left ventricular systolic function. J Am Coll Cardiol 2004; 43: 317–327PubMedCrossRef
12.
Zurück zum Zitat de Giuli F, Khaw KT, Cowie MR, et al. Incidence and outcome of persons with a clinical diagnosis of heart failure in a general practice population of 696 884 in the United Kingdom. Eur J Heart Fail 2005; 7: 295–302PubMedCrossRef de Giuli F, Khaw KT, Cowie MR, et al. Incidence and outcome of persons with a clinical diagnosis of heart failure in a general practice population of 696 884 in the United Kingdom. Eur J Heart Fail 2005; 7: 295–302PubMedCrossRef
13.
Zurück zum Zitat Cowie MR, Wood DA, Coats AJ, et al. Incidence and aetiology of heart failure: a population-based study. Eur Heart J 1999; 20: 421–428PubMedCrossRef Cowie MR, Wood DA, Coats AJ, et al. Incidence and aetiology of heart failure: a population-based study. Eur Heart J 1999; 20: 421–428PubMedCrossRef
14.
Zurück zum Zitat McMurray J, McDonagh T, Morrison CE, et al. Trends in hospitalization for heart failure in Scotland 1980–1990. Eur Heart J 1993; 14: 1158–1162PubMedCrossRef McMurray J, McDonagh T, Morrison CE, et al. Trends in hospitalization for heart failure in Scotland 1980–1990. Eur Heart J 1993; 14: 1158–1162PubMedCrossRef
15.
Zurück zum Zitat Gaasch WH. Diagnosis and treatment of heart failure based on left ventricular systolic or diastolic dysfunction. JAMA 1994; 271: 1276–1280PubMedCrossRef Gaasch WH. Diagnosis and treatment of heart failure based on left ventricular systolic or diastolic dysfunction. JAMA 1994; 271: 1276–1280PubMedCrossRef
16.
Zurück zum Zitat Owan TE, Hodge DO, Herges RM, et al. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 2006; 355: 251–259PubMedCrossRef Owan TE, Hodge DO, Herges RM, et al. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 2006; 355: 251–259PubMedCrossRef
17.
Zurück zum Zitat Bhatia RS, Tu JV, Lee DS, et al. Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med 2006; 355: 260–269PubMedCrossRef Bhatia RS, Tu JV, Lee DS, et al. Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med 2006; 355: 260–269PubMedCrossRef
18.
Zurück zum Zitat Lenzen MJ, Scholte op Reimer WJ, Boersma E, et al. Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey. Eur Heart J 2004; 25: 1214–1220PubMedCrossRef Lenzen MJ, Scholte op Reimer WJ, Boersma E, et al. Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey. Eur Heart J 2004; 25: 1214–1220PubMedCrossRef
19.
Zurück zum Zitat Stewart S, Jenkins A, Buchan S, et al. The current cost of heart failure to the National Health Service in the UK. Eur J Heart Fail 2002; 4: 361–371PubMedCrossRef Stewart S, Jenkins A, Buchan S, et al. The current cost of heart failure to the National Health Service in the UK. Eur J Heart Fail 2002; 4: 361–371PubMedCrossRef
20.
Zurück zum Zitat Rodriguez-Artalejo F, Guallar-Castillon P, Banegas Jr B, et al. Trends in hospitalization and mortality for heart failure in Spain, 1980–1993. Eur Heart J 1997; 18: 1771–1779PubMedCrossRef Rodriguez-Artalejo F, Guallar-Castillon P, Banegas Jr B, et al. Trends in hospitalization and mortality for heart failure in Spain, 1980–1993. Eur Heart J 1997; 18: 1771–1779PubMedCrossRef
21.
Zurück zum Zitat Launois R, Launois B, Reboul-Marty J, et al. Le cout de la severite de la maladie: le cas de rinsuffisance-cardiaque. J Econ Med 1990; 8: 395–312 Launois R, Launois B, Reboul-Marty J, et al. Le cout de la severite de la maladie: le cas de rinsuffisance-cardiaque. J Econ Med 1990; 8: 395–312
22.
Zurück zum Zitat Agvall B, Borgquist L, Foldevi M, et al. Cost of heart failure in Swedish primary healthcare. Scand J Prim Health Care 2005; 23: 227–232PubMedCrossRef Agvall B, Borgquist L, Foldevi M, et al. Cost of heart failure in Swedish primary healthcare. Scand J Prim Health Care 2005; 23: 227–232PubMedCrossRef
23.
Zurück zum Zitat Meerding WJ, Bonneux L, Polder J J, et al. Demographic and epidemiological determinants of healthcare costs in Netherlands: cost of illness study. Br Med J 1998; 317: 111–116CrossRef Meerding WJ, Bonneux L, Polder J J, et al. Demographic and epidemiological determinants of healthcare costs in Netherlands: cost of illness study. Br Med J 1998; 317: 111–116CrossRef
24.
Zurück zum Zitat McMurray J, Hart W, Rhodes G. An evaluation of the cost of heart failure to the national health service in the UK. Br J Med Econ 1993; 6: 91–98 McMurray J, Hart W, Rhodes G. An evaluation of the cost of heart failure to the national health service in the UK. Br J Med Econ 1993; 6: 91–98
26.
Zurück zum Zitat Ng TP, Niti M. Trends and ethnic differences in hospital admissions and mortality for congestive heart failure in the elderly in Singapore, 1991 to 1998. Heart 2003; 89: 865–870PubMedCrossRef Ng TP, Niti M. Trends and ethnic differences in hospital admissions and mortality for congestive heart failure in the elderly in Singapore, 1991 to 1998. Heart 2003; 89: 865–870PubMedCrossRef
27.
Zurück zum Zitat Feldman DE, Thivierge C, Guerard L, et al. Changing trends in mortality and admissions to hospital for elderly patients with congestive heart failure in Montreal. CMAJ 2001; 165: 1033–1036PubMed Feldman DE, Thivierge C, Guerard L, et al. Changing trends in mortality and admissions to hospital for elderly patients with congestive heart failure in Montreal. CMAJ 2001; 165: 1033–1036PubMed
28.
Zurück zum Zitat Foot DK, Lewis RP, Pearson TA, et al. Demographics and cardiology, 1950–2050. J Am Coll Cardiol 2000; 35: 1067–1081PubMedCrossRef Foot DK, Lewis RP, Pearson TA, et al. Demographics and cardiology, 1950–2050. J Am Coll Cardiol 2000; 35: 1067–1081PubMedCrossRef
29.
Zurück zum Zitat Masoudi FA, Havranek EP, Krumholz HM. The burden of chronic congestive heart failure in older persons: magnitude and implications for policy and research. Heart Fail Rev 2002; 7: 9–16PubMedCrossRef Masoudi FA, Havranek EP, Krumholz HM. The burden of chronic congestive heart failure in older persons: magnitude and implications for policy and research. Heart Fail Rev 2002; 7: 9–16PubMedCrossRef
30.
Zurück zum Zitat Stewart S, Maclntyre K, Capewell S, et al. Heart failure and the aging population: an increasing burden in the 21st century? Heart 2003; 89: 49–53PubMedCrossRef Stewart S, Maclntyre K, Capewell S, et al. Heart failure and the aging population: an increasing burden in the 21st century? Heart 2003; 89: 49–53PubMedCrossRef
31.
Zurück zum Zitat Polanczyk CA, Rohde LE, Dec GW, et al. Ten-year trends in hospital care for congestive heart failure: improved outcomes and increased use of resources. Arch Intern Med 2000; 160: 325–332PubMedCrossRef Polanczyk CA, Rohde LE, Dec GW, et al. Ten-year trends in hospital care for congestive heart failure: improved outcomes and increased use of resources. Arch Intern Med 2000; 160: 325–332PubMedCrossRef
32.
Zurück zum Zitat Malek M. Health economics of heart failure. Heart 1999; 82: IV11–IV13PubMed Malek M. Health economics of heart failure. Heart 1999; 82: IV11–IV13PubMed
33.
Zurück zum Zitat Stroupe KT, Forthofer MM, Brater DC, et al. Healthcare costs of patients with heart failure treated with torasemide or furosemide. Pharmacoeconomics 2000; 17: 429–440PubMedCrossRef Stroupe KT, Forthofer MM, Brater DC, et al. Healthcare costs of patients with heart failure treated with torasemide or furosemide. Pharmacoeconomics 2000; 17: 429–440PubMedCrossRef
34.
Zurück zum Zitat Cowie MR, Fox KF, Wood DA, et al. Hospitalization of patients with heart failure: a population-based study. Eur Heart J 2002; 23: 877–885PubMedCrossRef Cowie MR, Fox KF, Wood DA, et al. Hospitalization of patients with heart failure: a population-based study. Eur Heart J 2002; 23: 877–885PubMedCrossRef
35.
Zurück zum Zitat Wexler DJ, Chen J, Smith GL, et al. Predictors of costs of caring for elderly patients discharged with heart failure. Am Heart J 2001; 142: 350–357PubMedCrossRef Wexler DJ, Chen J, Smith GL, et al. Predictors of costs of caring for elderly patients discharged with heart failure. Am Heart J 2001; 142: 350–357PubMedCrossRef
36.
Zurück zum Zitat Cleland JG, Swedberg K, Follath F, et al. TheEuroHeart Failure survey programme: a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis. Eur Heart J 2003; 24: 442–463PubMedCrossRef Cleland JG, Swedberg K, Follath F, et al. TheEuroHeart Failure survey programme: a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis. Eur Heart J 2003; 24: 442–463PubMedCrossRef
37.
Zurück zum Zitat Fonarow GC, Heywood JT, Heidenreich PA, et al. Temporal trends in clinical characteristics, treatments, and outcomes for heart failure hospitalizations, 2002 to 2004: findings from Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J 2007; 153: 1021–1028PubMedCrossRef Fonarow GC, Heywood JT, Heidenreich PA, et al. Temporal trends in clinical characteristics, treatments, and outcomes for heart failure hospitalizations, 2002 to 2004: findings from Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J 2007; 153: 1021–1028PubMedCrossRef
39.
Zurück zum Zitat Schappert SM, Burt CW. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 2001–02. Vital Health Stat 13 2006 Feb; (159): 1–66PubMed Schappert SM, Burt CW. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 2001–02. Vital Health Stat 13 2006 Feb; (159): 1–66PubMed
40.
Zurück zum Zitat Liao L, Anstrom KJ, Gottdiener JS, et al. Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study. Am Heart J 2007; 153: 245–252PubMedCrossRef Liao L, Anstrom KJ, Gottdiener JS, et al. Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study. Am Heart J 2007; 153: 245–252PubMedCrossRef
41.
Zurück zum Zitat Masoudi FA, Baillie CA, Wang Y, et al. The complexity and cost of drug regimens of older patients hospitalized with heart failure in the United States, 1998–2001. Arch Intern Med 2005; 165: 2069–2076PubMedCrossRef Masoudi FA, Baillie CA, Wang Y, et al. The complexity and cost of drug regimens of older patients hospitalized with heart failure in the United States, 1998–2001. Arch Intern Med 2005; 165: 2069–2076PubMedCrossRef
42.
Zurück zum Zitat Komajda M, Follath F, Swedberg K, et al. The EuroHeart Failure Survey programme: a survey on the quality of care among patients with heart failure in Europe. Part II: treatment. Eur Heart J 2003; 24: 464–474PubMedCrossRef Komajda M, Follath F, Swedberg K, et al. The EuroHeart Failure Survey programme: a survey on the quality of care among patients with heart failure in Europe. Part II: treatment. Eur Heart J 2003; 24: 464–474PubMedCrossRef
43.
Zurück zum Zitat Cleland JG, Cohen-Solal A, Aguilar JC, et al. Management of heart failure in primary care (the IMPROVEMENT of Heart Failure Programme): an international survey. Lancet 2002; 360: 1631–1639PubMedCrossRef Cleland JG, Cohen-Solal A, Aguilar JC, et al. Management of heart failure in primary care (the IMPROVEMENT of Heart Failure Programme): an international survey. Lancet 2002; 360: 1631–1639PubMedCrossRef
44.
Zurück zum Zitat Rich MW, Beckham V, Wittenberg C, et al. A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 1995; 333: 1190–1195PubMedCrossRef Rich MW, Beckham V, Wittenberg C, et al. A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 1995; 333: 1190–1195PubMedCrossRef
45.
Zurück zum Zitat Davey PG, Clarkson PB, McMahon A, et al. Costs associated with symptomatic systolic heart failure. Pharmacoeconomics 1999; 16: 399–407PubMedCrossRef Davey PG, Clarkson PB, McMahon A, et al. Costs associated with symptomatic systolic heart failure. Pharmacoeconomics 1999; 16: 399–407PubMedCrossRef
46.
Zurück zum Zitat Philbin EF, Rocco Jr TA, Lindenmuth NW, et al. Systolic versus diastolic heart failure in community practice: clinical features, outcomes, and the use of angiotensin-converting enzyme inhibitors. Am J Med 2000; 109: 605–613PubMedCrossRef Philbin EF, Rocco Jr TA, Lindenmuth NW, et al. Systolic versus diastolic heart failure in community practice: clinical features, outcomes, and the use of angiotensin-converting enzyme inhibitors. Am J Med 2000; 109: 605–613PubMedCrossRef
47.
Zurück zum Zitat Liao L, Jollis JG, Anstrom KJ, et al. Costs for heart failure with normal vs reduced ejection fraction. Arch Intern Med 2006; 166: 112–118PubMedCrossRef Liao L, Jollis JG, Anstrom KJ, et al. Costs for heart failure with normal vs reduced ejection fraction. Arch Intern Med 2006; 166: 112–118PubMedCrossRef
48.
Zurück zum Zitat Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). Developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation 2005; 112: el54–el235CrossRef Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). Developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation 2005; 112: el54–el235CrossRef
49.
Zurück zum Zitat Reed SD, Friedman JY, Velazquez EJ, et al. Multinational economic evaluation of valsartan in patients with chronic heart failure: results from the Valsartan Heart Failure Trial (Val-HeFT). Am Heart J 2004; 148: 122–128PubMedCrossRef Reed SD, Friedman JY, Velazquez EJ, et al. Multinational economic evaluation of valsartan in patients with chronic heart failure: results from the Valsartan Heart Failure Trial (Val-HeFT). Am Heart J 2004; 148: 122–128PubMedCrossRef
50.
Zurück zum Zitat Auerbach AD, Hamel MB, Davis RB, et al. Resource use and survival of patients hospitalized with congestive heart failure: differences in care by specialty of the attending physician. SUPPORT Investigators: Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Ann Intern Med 2000; 132: 191–200PubMed Auerbach AD, Hamel MB, Davis RB, et al. Resource use and survival of patients hospitalized with congestive heart failure: differences in care by specialty of the attending physician. SUPPORT Investigators: Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Ann Intern Med 2000; 132: 191–200PubMed
51.
Zurück zum Zitat Weintraub WS, Kawabata H, Tran M, et al. Influence of comorbidity on cost of care for heart failure. Am J Cardiol 2003; 91: 1011–1015, A8PubMedCrossRef Weintraub WS, Kawabata H, Tran M, et al. Influence of comorbidity on cost of care for heart failure. Am J Cardiol 2003; 91: 1011–1015, A8PubMedCrossRef
52.
Zurück zum Zitat Berry C, McMurray J. A review of quality-of-life evaluations in patients with congestive heart failure. Pharmacoeconomics 1999; 16: 247–271PubMedCrossRef Berry C, McMurray J. A review of quality-of-life evaluations in patients with congestive heart failure. Pharmacoeconomics 1999; 16: 247–271PubMedCrossRef
53.
Zurück zum Zitat Ekman I, Fagerberg B, Lundman B. Health-related quality of life and sense of coherence among elderly patients with severe chronic heart failure in comparison with healthy controls. Heart Lung 2002; 31: 94–101PubMedCrossRef Ekman I, Fagerberg B, Lundman B. Health-related quality of life and sense of coherence among elderly patients with severe chronic heart failure in comparison with healthy controls. Heart Lung 2002; 31: 94–101PubMedCrossRef
54.
Zurück zum Zitat Heo S, Moser DK, Lennie TA, et al. A comparison of health-related quality of life between older adults with heart failure and healthy older adults. Heart Lung 2007; 36: 16–24PubMedCrossRef Heo S, Moser DK, Lennie TA, et al. A comparison of health-related quality of life between older adults with heart failure and healthy older adults. Heart Lung 2007; 36: 16–24PubMedCrossRef
55.
Zurück zum Zitat Calvert MJ, Freemantle N, Cleland JG. The impact of chronic heart failure on health-related quality of life data acquired in the baseline phase of the CARE-HF study. Eur J Heart Fail 2005; 7: 243–251PubMedCrossRef Calvert MJ, Freemantle N, Cleland JG. The impact of chronic heart failure on health-related quality of life data acquired in the baseline phase of the CARE-HF study. Eur J Heart Fail 2005; 7: 243–251PubMedCrossRef
56.
Zurück zum Zitat Rao A, Asadi-Lari M, Walsh J, et al. Quality of life in patients with signs and symptoms of heart failure: does systolic function matter? J Card Fail 2006; 12: 677–683PubMedCrossRef Rao A, Asadi-Lari M, Walsh J, et al. Quality of life in patients with signs and symptoms of heart failure: does systolic function matter? J Card Fail 2006; 12: 677–683PubMedCrossRef
57.
Zurück zum Zitat Weintraub WS, Cole J, Tooley JF. Cost and cost-effectiveness studies in heart failure research. Am Heart J 2002; 143: 565–576PubMedCrossRef Weintraub WS, Cole J, Tooley JF. Cost and cost-effectiveness studies in heart failure research. Am Heart J 2002; 143: 565–576PubMedCrossRef
58.
Zurück zum Zitat Weintraub WS, Zhang Z, Mahoney EM, et al. Cost-effectiveness of eplerenone compared with placebo in patients with myocardial infarction complicated by left ventricular dysfunction and heart failure. Circulation 2005; 111: 1106–1113PubMedCrossRef Weintraub WS, Zhang Z, Mahoney EM, et al. Cost-effectiveness of eplerenone compared with placebo in patients with myocardial infarction complicated by left ventricular dysfunction and heart failure. Circulation 2005; 111: 1106–1113PubMedCrossRef
59.
Zurück zum Zitat Skrepnek GH, Abarca J, Malone DC, et al. Incremental effects of concurrent pharmacotherapeutic regimens for heart failure on hospitalizations and costs. Ann Pharmacother 2005; 39: 1785–1791PubMedCrossRef Skrepnek GH, Abarca J, Malone DC, et al. Incremental effects of concurrent pharmacotherapeutic regimens for heart failure on hospitalizations and costs. Ann Pharmacother 2005; 39: 1785–1791PubMedCrossRef
60.
Zurück zum Zitat Del Sindaco D, Pulignano G, Minardi G, et al. Two-year outcome of a prospective, controlled study of a disease management programme for elderly patients with heart failure. J Cardiovasc Med (Hagerstown) 2007; 8: 324–329CrossRef Del Sindaco D, Pulignano G, Minardi G, et al. Two-year outcome of a prospective, controlled study of a disease management programme for elderly patients with heart failure. J Cardiovasc Med (Hagerstown) 2007; 8: 324–329CrossRef
61.
Zurück zum Zitat Sanders GD, Hlatky MA, Every NR, et al. Potential cost-effectiveness of prophylactic use of the implantable cardioverter defibrillator or amiodarone after myocardial infarction. Ann Intern Med 2001 Nov 20; 135 (10): 870–883PubMed Sanders GD, Hlatky MA, Every NR, et al. Potential cost-effectiveness of prophylactic use of the implantable cardioverter defibrillator or amiodarone after myocardial infarction. Ann Intern Med 2001 Nov 20; 135 (10): 870–883PubMed
62.
Zurück zum Zitat Yao G, Freemantle N, Calvert MJ, et al. The long-term cost-effectiveness of cardiac resynchronization therapy with or without an implantable cardioverter-defibrillator. Eur Heart J 2007; 28: 42–51PubMedCrossRef Yao G, Freemantle N, Calvert MJ, et al. The long-term cost-effectiveness of cardiac resynchronization therapy with or without an implantable cardioverter-defibrillator. Eur Heart J 2007; 28: 42–51PubMedCrossRef
63.
Zurück zum Zitat Clegg AJ, Scott DA, Loveman E, et al. Clinical and cost-effectiveness of left ventricular assist devices as destination therapy for people with end-stage heart failure: a systematic review and economic evaluation. Int J Technol Assess Health Care 2007; 23: 261–268PubMedCrossRef Clegg AJ, Scott DA, Loveman E, et al. Clinical and cost-effectiveness of left ventricular assist devices as destination therapy for people with end-stage heart failure: a systematic review and economic evaluation. Int J Technol Assess Health Care 2007; 23: 261–268PubMedCrossRef
64.
Zurück zum Zitat Ward RE, Gheorghiade M, Young JB, et al. Economic outcomes of withdrawal of digoxin therapy in adult patients with stable congestive heart failure. J Am Coll Cardiol 1995; 26: 93–101PubMedCrossRef Ward RE, Gheorghiade M, Young JB, et al. Economic outcomes of withdrawal of digoxin therapy in adult patients with stable congestive heart failure. J Am Coll Cardiol 1995; 26: 93–101PubMedCrossRef
65.
Zurück zum Zitat Eisenstein EL, Yusuf S, Bindal V, et al. What is the economic value of digoxin therapy in congestive heart failure patients? Results from the DIG trial. J Card Fail 2006; 12: 336–342PubMedCrossRef Eisenstein EL, Yusuf S, Bindal V, et al. What is the economic value of digoxin therapy in congestive heart failure patients? Results from the DIG trial. J Card Fail 2006; 12: 336–342PubMedCrossRef
66.
Zurück zum Zitat Schadlich PK, Paschen B, Brecht JG. Economic evaluation of the Cardiac Insufficiency Bisoprolol Study for the Federal Republic of Germany. Pharmacoeconomics 1998; 13: 147–155PubMedCrossRef Schadlich PK, Paschen B, Brecht JG. Economic evaluation of the Cardiac Insufficiency Bisoprolol Study for the Federal Republic of Germany. Pharmacoeconomics 1998; 13: 147–155PubMedCrossRef
67.
Zurück zum Zitat Levy P, Lechat P, Leizorovicz A, et al. A cost-minimization of heart failure therapy with bisoprolol in the French setting: an analysis from CIBIS trial data. Cardiac Insufficiency Bisoprolol Study. Cardiovasc Drugs Ther 1998; 12: 301–305PubMedCrossRef Levy P, Lechat P, Leizorovicz A, et al. A cost-minimization of heart failure therapy with bisoprolol in the French setting: an analysis from CIBIS trial data. Cardiac Insufficiency Bisoprolol Study. Cardiovasc Drugs Ther 1998; 12: 301–305PubMedCrossRef
68.
Zurück zum Zitat Di Stasi F, Sealone L, De Portu S, et al. Cost-effectiveness analysis of bisoprolol treatment for heart failure. Ital Heart J 2005; 6: 950–955PubMed Di Stasi F, Sealone L, De Portu S, et al. Cost-effectiveness analysis of bisoprolol treatment for heart failure. Ital Heart J 2005; 6: 950–955PubMed
69.
Zurück zum Zitat Ekman M, Zethraeus N, Jonsson B. Cost effectiveness of bisoprolol in the treatment of chronic congestive heart failure in Sweden: analysis using data from the Cardiac Insufficiency Bisoprolol Study II trial. Pharmacoeconomics 2001; 19: 901–916PubMedCrossRef Ekman M, Zethraeus N, Jonsson B. Cost effectiveness of bisoprolol in the treatment of chronic congestive heart failure in Sweden: analysis using data from the Cardiac Insufficiency Bisoprolol Study II trial. Pharmacoeconomics 2001; 19: 901–916PubMedCrossRef
70.
Zurück zum Zitat Reduced costs with bisoprolol treatment for heart failure: an economic analysis of the second Cardiac Insufficiency Bisoprolol Study (CIBIS-II). Eur Heart J 2001; 22 (12): 1021-31 Reduced costs with bisoprolol treatment for heart failure: an economic analysis of the second Cardiac Insufficiency Bisoprolol Study (CIBIS-II). Eur Heart J 2001; 22 (12): 1021-31
71.
Zurück zum Zitat Caro JJ, Migliaccio-Walle K, O’Brien JA, et al. Economic implications of extended-release metoprolol succinate for heart failure in the MERIT-HF trial: a US perspective of the MERIT-HF trial. J Card Fail 2005; 11: 647–656PubMedCrossRef Caro JJ, Migliaccio-Walle K, O’Brien JA, et al. Economic implications of extended-release metoprolol succinate for heart failure in the MERIT-HF trial: a US perspective of the MERIT-HF trial. J Card Fail 2005; 11: 647–656PubMedCrossRef
72.
Zurück zum Zitat Fowler MB, Vera-Llonch M, Oster G, et al. Influence of carvedilol on hospitalizations in heart failure: incidence, resource utilization and costs. US Carvedilol Heart Failure Study Group. J Am Coll Cardiol 2001; 37: 1692–1699PubMedCrossRef Fowler MB, Vera-Llonch M, Oster G, et al. Influence of carvedilol on hospitalizations in heart failure: incidence, resource utilization and costs. US Carvedilol Heart Failure Study Group. J Am Coll Cardiol 2001; 37: 1692–1699PubMedCrossRef
73.
Zurück zum Zitat Packer M, Coats AJ, Fowler MB, et al. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 2001; 344: 1651–1658PubMedCrossRef Packer M, Coats AJ, Fowler MB, et al. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 2001; 344: 1651–1658PubMedCrossRef
74.
Zurück zum Zitat Stewart S, McMurray JJ, Hebborn A, et al. Carvedilol reduces the costs of medical care in severe heart failure: an economic analysis of the COPERNICUS study applied to the United Kingdom. Int J Cardiol 2005; 100: 143–149PubMedCrossRef Stewart S, McMurray JJ, Hebborn A, et al. Carvedilol reduces the costs of medical care in severe heart failure: an economic analysis of the COPERNICUS study applied to the United Kingdom. Int J Cardiol 2005; 100: 143–149PubMedCrossRef
75.
Zurück zum Zitat Levy AR, Briggs AH, Demers C, et al. Cost-effectiveness of beta-blocker therapy with metoprolol or with carvedilol for treatment of heart failure in Canada. Am Heart J 2001; 142: 537–543PubMedCrossRef Levy AR, Briggs AH, Demers C, et al. Cost-effectiveness of beta-blocker therapy with metoprolol or with carvedilol for treatment of heart failure in Canada. Am Heart J 2001; 142: 537–543PubMedCrossRef
76.
Zurück zum Zitat Szucs TD, Holm MV, Schwenkglenks M, et al. Cost-effectiveness of eplerenone in patients with left ventricular dysfunction after myocardial infarction: an analysis of the EPHESUS study from a Swiss perspective. Cardiovasc Drugs Ther 2006; 20: 193–204PubMedCrossRef Szucs TD, Holm MV, Schwenkglenks M, et al. Cost-effectiveness of eplerenone in patients with left ventricular dysfunction after myocardial infarction: an analysis of the EPHESUS study from a Swiss perspective. Cardiovasc Drugs Ther 2006; 20: 193–204PubMedCrossRef
77.
Zurück zum Zitat Spannheimer A, Goertz A, Dreckmann-Behrendt B. Comparison of therapies with torasemide or furosemide in patients with congestive heart failure from a pharmacoeconomic viewpoint. Int J Clin Pract 1998; 52: 467–471PubMed Spannheimer A, Goertz A, Dreckmann-Behrendt B. Comparison of therapies with torasemide or furosemide in patients with congestive heart failure from a pharmacoeconomic viewpoint. Int J Clin Pract 1998; 52: 467–471PubMed
78.
Zurück zum Zitat Noe LL, Vreeland MG, Pezzella SM, et al. A pharmacoeconomic assessment of torsemide and furosemide in the treatment of patients with congestive heart failure. Clin Ther 1999; 21: 854–866PubMedCrossRef Noe LL, Vreeland MG, Pezzella SM, et al. A pharmacoeconomic assessment of torsemide and furosemide in the treatment of patients with congestive heart failure. Clin Ther 1999; 21: 854–866PubMedCrossRef
79.
Zurück zum Zitat Heaton AH, Bryant J, Berman BN, et al. Pharmacoeconomic comparison of loop diuretics in the treatment of congestive heart failure. Med Interface 1996; 9: 101–107PubMed Heaton AH, Bryant J, Berman BN, et al. Pharmacoeconomic comparison of loop diuretics in the treatment of congestive heart failure. Med Interface 1996; 9: 101–107PubMed
80.
Zurück zum Zitat Glick HA, Orzol SM, Tooley JF, et al. Economic evaluation of the randomized aldactone evaluation study (RALES): treatment of patients with severe heart failure. Cardiovasc Drugs Ther 2002; 16: 53–59PubMedCrossRef Glick HA, Orzol SM, Tooley JF, et al. Economic evaluation of the randomized aldactone evaluation study (RALES): treatment of patients with severe heart failure. Cardiovasc Drugs Ther 2002; 16: 53–59PubMedCrossRef
81.
Zurück zum Zitat Tilson L, McGowan B, Ryan M, et al. Cost-effectiveness of spironolactone in patients with severe heart failure. Ir J Med Sci 2003; 172: 70–72PubMedCrossRef Tilson L, McGowan B, Ryan M, et al. Cost-effectiveness of spironolactone in patients with severe heart failure. Ir J Med Sci 2003; 172: 70–72PubMedCrossRef
82.
Zurück zum Zitat Abarca J, Malone DC, Armstrong EP, et al. Angiotensin-con-verting enzyme inhibitor therapy in patients with heart failure enrolled in a managed care organization: effect on costs and probability of hospitalization Pharmacotherapy 2004; 24: 351–357PubMedCrossRef Abarca J, Malone DC, Armstrong EP, et al. Angiotensin-con-verting enzyme inhibitor therapy in patients with heart failure enrolled in a managed care organization: effect on costs and probability of hospitalization Pharmacotherapy 2004; 24: 351–357PubMedCrossRef
83.
Zurück zum Zitat Schwartz JS, Wang YR, Cleland JG, et al. High- versus low-dose angiotensin converting enzyme inhibitor therapy in the treatment of heart failure: an economic analysis of the Assessment of Treatment with Lisinopril and Survival (ATLAS) trial. Am J Manag Care 2003; 9: 417–424PubMed Schwartz JS, Wang YR, Cleland JG, et al. High- versus low-dose angiotensin converting enzyme inhibitor therapy in the treatment of heart failure: an economic analysis of the Assessment of Treatment with Lisinopril and Survival (ATLAS) trial. Am J Manag Care 2003; 9: 417–424PubMed
84.
Zurück zum Zitat Sculpher MJ, Poole L, Cleland J, et al. Low doses vs high doses of the angiotensin converting-enzyme inhibitor lisinopril in chronic heart failure: a cost-effectiveness analysis based on the Assessment of Treatment with Lisinopril and Survival (ATLAS) study. The ATLAS Study Group. Eur J Heart Fail 2000; 2: 447–454PubMedCrossRef Sculpher MJ, Poole L, Cleland J, et al. Low doses vs high doses of the angiotensin converting-enzyme inhibitor lisinopril in chronic heart failure: a cost-effectiveness analysis based on the Assessment of Treatment with Lisinopril and Survival (ATLAS) study. The ATLAS Study Group. Eur J Heart Fail 2000; 2: 447–454PubMedCrossRef
85.
Zurück zum Zitat Paul SD, Kuntz KM, Eagle KA, et al. Costs and effectiveness of angiotensin converting enzyme inhibition in patients with congestive heart failure. Arch Intern Med 1994; 154: 1143–1149PubMedCrossRef Paul SD, Kuntz KM, Eagle KA, et al. Costs and effectiveness of angiotensin converting enzyme inhibition in patients with congestive heart failure. Arch Intern Med 1994; 154: 1143–1149PubMedCrossRef
86.
Zurück zum Zitat Glick H, Cook J, Kinosian B, et al. Costs and effects of enalapril therapy in patients with symptomatic heart failure: an economic analysis of the Studies of Left Ventricular Dysfunction (SOLVD) treatment trial. J Card Fail 1995; 1: 371–380PubMedCrossRef Glick H, Cook J, Kinosian B, et al. Costs and effects of enalapril therapy in patients with symptomatic heart failure: an economic analysis of the Studies of Left Ventricular Dysfunction (SOLVD) treatment trial. J Card Fail 1995; 1: 371–380PubMedCrossRef
87.
Zurück zum Zitat Angus DC, Linde-Zwirble WT, Tam SW, et al. Cost-effectiveness of fixed-dose combination of isosorbide dinitrate and hydralazine therapy for blacks with heart failure. Circulation 2005; 112: 3745–3753PubMedCrossRef Angus DC, Linde-Zwirble WT, Tam SW, et al. Cost-effectiveness of fixed-dose combination of isosorbide dinitrate and hydralazine therapy for blacks with heart failure. Circulation 2005; 112: 3745–3753PubMedCrossRef
88.
Zurück zum Zitat Reed SD, Radeva JI, Weinfurt KP, et al. Resource use, costs, and quality of life among patients in the multinational Valsartan in Acute Myocardial Infarction Trial (VALIANT). Am Heart J 2005; 150: 323–329PubMedCrossRef Reed SD, Radeva JI, Weinfurt KP, et al. Resource use, costs, and quality of life among patients in the multinational Valsartan in Acute Myocardial Infarction Trial (VALIANT). Am Heart J 2005; 150: 323–329PubMedCrossRef
89.
Zurück zum Zitat McMurray JJ, Andersson FL, Stewart S, et al. Resource utilization and costs in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme. Eur Heart J 2006; 27: 1447–1458PubMedCrossRef McMurray JJ, Andersson FL, Stewart S, et al. Resource utilization and costs in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme. Eur Heart J 2006; 27: 1447–1458PubMedCrossRef
90.
Zurück zum Zitat Garg R, Yusuf S. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials. JAMA 1995; 273: 1450–1456PubMedCrossRef Garg R, Yusuf S. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials. JAMA 1995; 273: 1450–1456PubMedCrossRef
91.
Zurück zum Zitat Hummel S, Piercy J, Wright R, et al. An economic analysis of the Survival and Ventricular Enlargement (SAVE) study: application to the United Kingdom. Pharmacoeconomics 1997; 12: 182–192PubMedCrossRef Hummel S, Piercy J, Wright R, et al. An economic analysis of the Survival and Ventricular Enlargement (SAVE) study: application to the United Kingdom. Pharmacoeconomics 1997; 12: 182–192PubMedCrossRef
92.
Zurück zum Zitat Boyko Jr WL, Glick HA, Schulman KA. Economics and cost-effectiveness in evaluating the value of cardiovascular therapies: ACE inhibitors in the management of congestive heart failure. Comparative economic data. Am Heart J 1999; 137: S115–S119PubMedCrossRef Boyko Jr WL, Glick HA, Schulman KA. Economics and cost-effectiveness in evaluating the value of cardiovascular therapies: ACE inhibitors in the management of congestive heart failure. Comparative economic data. Am Heart J 1999; 137: S115–S119PubMedCrossRef
93.
Zurück zum Zitat McMurray J J, McGuire A, Davie AP, et al. Cost-effectiveness of different ACE inhibitor treatment scenarios post-myocardial infarction. Eur Heart J 1997; 18: 1411–1415PubMedCrossRef McMurray J J, McGuire A, Davie AP, et al. Cost-effectiveness of different ACE inhibitor treatment scenarios post-myocardial infarction. Eur Heart J 1997; 18: 1411–1415PubMedCrossRef
94.
Zurück zum Zitat McMurray JJ, Ostergren J, Swedberg K, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet 2003; 362: 767–771PubMedCrossRef McMurray JJ, Ostergren J, Swedberg K, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet 2003; 362: 767–771PubMedCrossRef
95.
Zurück zum Zitat Pfeffer MA, McMurray JJ, Velazquez EJ, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 2003; 349: 1893–1906PubMedCrossRef Pfeffer MA, McMurray JJ, Velazquez EJ, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 2003; 349: 1893–1906PubMedCrossRef
96.
Zurück zum Zitat Gilbert EM. Cost-effectiveness of beta-blocker treatment in heart failure. Rev Cardiovasc Med 2002; 3 Suppl. 3: S42–S47PubMed Gilbert EM. Cost-effectiveness of beta-blocker treatment in heart failure. Rev Cardiovasc Med 2002; 3 Suppl. 3: S42–S47PubMed
97.
Zurück zum Zitat Cowper PA, DeLong ER, Whellan DJ, et al. Economic effects of beta-blocker therapy in patients with heart failure. Am J Med 2004; 116: 104–111PubMedCrossRef Cowper PA, DeLong ER, Whellan DJ, et al. Economic effects of beta-blocker therapy in patients with heart failure. Am J Med 2004; 116: 104–111PubMedCrossRef
98.
Zurück zum Zitat Delea TE, Stanford R, Hagiwara M, et al. Death and hospitalization in heart failure patients receiving carvedilol vs metoprolol tartrate. Int J Cardiol 2005; 99: 117–124PubMedCrossRef Delea TE, Stanford R, Hagiwara M, et al. Death and hospitalization in heart failure patients receiving carvedilol vs metoprolol tartrate. Int J Cardiol 2005; 99: 117–124PubMedCrossRef
99.
Zurück zum Zitat Croom KF, Plosker GL. Eplerenone: a pharmacoeconomic review of its use in patients with post-myocardial infarction heart failure. Pharmacoeconomics 2005; 23: 1057–1072PubMedCrossRef Croom KF, Plosker GL. Eplerenone: a pharmacoeconomic review of its use in patients with post-myocardial infarction heart failure. Pharmacoeconomics 2005; 23: 1057–1072PubMedCrossRef
100.
Zurück zum Zitat Young M, Plosker GL. Torasemide: a pharmacoeconomic review of its use in chronic heart failure. Pharmacoeconomics 2001; 19: 679–703PubMedCrossRef Young M, Plosker GL. Torasemide: a pharmacoeconomic review of its use in chronic heart failure. Pharmacoeconomics 2001; 19: 679–703PubMedCrossRef
101.
Zurück zum Zitat Philbin EF, Rocco TA. Use of angiotensin-converting enzyme inhibitors in heart failure with preserved left ventricular systolic function. Am Heart J 2001; 134: 188–195CrossRef Philbin EF, Rocco TA. Use of angiotensin-converting enzyme inhibitors in heart failure with preserved left ventricular systolic function. Am Heart J 2001; 134: 188–195CrossRef
102.
Zurück zum Zitat Taylor DH, Whellan DJ, Sloan FA. Effects of admission to a teaching hospital on the cost and quality of care for medicare beneficiaries. N Engl J Med 1999; 340: 293–299PubMedCrossRef Taylor DH, Whellan DJ, Sloan FA. Effects of admission to a teaching hospital on the cost and quality of care for medicare beneficiaries. N Engl J Med 1999; 340: 293–299PubMedCrossRef
103.
Zurück zum Zitat Jollis JG, Ancukiewicz M, DeLong ER, et al. Discordance of databases designed for claims payment versus clinical information systems: implications for outcomes research. Ann Intern Med 1993; 119: 844–850PubMed Jollis JG, Ancukiewicz M, DeLong ER, et al. Discordance of databases designed for claims payment versus clinical information systems: implications for outcomes research. Ann Intern Med 1993; 119: 844–850PubMed
104.
Zurück zum Zitat Psaty BM, Boineau R, Kuller LH, et al. The potential costs of upcoding for heart failure in the United States. Am J Cardiol 1999; 84: 108–109PubMedCrossRef Psaty BM, Boineau R, Kuller LH, et al. The potential costs of upcoding for heart failure in the United States. Am J Cardiol 1999; 84: 108–109PubMedCrossRef
105.
Zurück zum Zitat Khand AU, Shaw M, Gemmel I, et al. Do discharge codes underestimate hospitalisation due to heart failure? Validation study of hospital discharge coding for heart failure. Eur J Heart Fail 2005; 7: 792–797PubMedCrossRef Khand AU, Shaw M, Gemmel I, et al. Do discharge codes underestimate hospitalisation due to heart failure? Validation study of hospital discharge coding for heart failure. Eur J Heart Fail 2005; 7: 792–797PubMedCrossRef
106.
Zurück zum Zitat Philbin EF, McCullough PA, Dec GW, et al. Length of stay and procedure utilization are the major determinants of hospital charges for heart failure. Clin Cardiol 2001; 24: 56–62PubMedCrossRef Philbin EF, McCullough PA, Dec GW, et al. Length of stay and procedure utilization are the major determinants of hospital charges for heart failure. Clin Cardiol 2001; 24: 56–62PubMedCrossRef
107.
Zurück zum Zitat Rich MW, Beckham V, Wittenberg C, et al. A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 1995; 333: 1190–1195PubMedCrossRef Rich MW, Beckham V, Wittenberg C, et al. A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 1995; 333: 1190–1195PubMedCrossRef
108.
Zurück zum Zitat Linne AB, Liedholm H, Jendteg S, et al. Health care costs of heart failure: results from a randomised study of patient education. Euro J Heart Fail 2000; 2: 291–297CrossRef Linne AB, Liedholm H, Jendteg S, et al. Health care costs of heart failure: results from a randomised study of patient education. Euro J Heart Fail 2000; 2: 291–297CrossRef
109.
Zurück zum Zitat Starling RC. The heart failure pandemic: changing patterns, costs, and treatment strategies. Cleve Clin J Med 1998; 65: 351–358PubMed Starling RC. The heart failure pandemic: changing patterns, costs, and treatment strategies. Cleve Clin J Med 1998; 65: 351–358PubMed
110.
Zurück zum Zitat Ho KK, Anderson KM, Kannel WB, et al. Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation 1993; 88: 107–115PubMedCrossRef Ho KK, Anderson KM, Kannel WB, et al. Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation 1993; 88: 107–115PubMedCrossRef
111.
Zurück zum Zitat Bennett SJ, Saywell RM, Zollinger TW, et al. Cost of hospitalizations for heart failure: sodium retention versus other decompensating factors. Heart Lung 1999; 28: 102–109PubMedCrossRef Bennett SJ, Saywell RM, Zollinger TW, et al. Cost of hospitalizations for heart failure: sodium retention versus other decompensating factors. Heart Lung 1999; 28: 102–109PubMedCrossRef
112.
Zurück zum Zitat Ni H, Nauman DJ, Hershberger RE. Analysis of trends in hospitalizations for heart failure. J Cardiac Fail 1999; 5: 79–84CrossRef Ni H, Nauman DJ, Hershberger RE. Analysis of trends in hospitalizations for heart failure. J Cardiac Fail 1999; 5: 79–84CrossRef
113.
Zurück zum Zitat Pfeffer MA, Swedberg K, Granger CB, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 2003; 362: 759–766PubMedCrossRef Pfeffer MA, Swedberg K, Granger CB, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 2003; 362: 759–766PubMedCrossRef
114.
Zurück zum Zitat Cohn JN, Tognoni G. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med 2001; 345: 1667–1675PubMedCrossRef Cohn JN, Tognoni G. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med 2001; 345: 1667–1675PubMedCrossRef
115.
Zurück zum Zitat Cleland JG, Tendera M, Adamus J, et al. The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J 2006; 27: 2338–2345PubMedCrossRef Cleland JG, Tendera M, Adamus J, et al. The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J 2006; 27: 2338–2345PubMedCrossRef
116.
Zurück zum Zitat Flather MD, Shibata MC, Coats AJ, et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005; 26: 215–225PubMedCrossRef Flather MD, Shibata MC, Coats AJ, et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005; 26: 215–225PubMedCrossRef
117.
Zurück zum Zitat Carson P, Massie BM, McKelvie R, et al. The irbesartan in heart failure with preserved systolic function (I-PRESERVE) trial: rationale and design. J Card Fail 2005; 11: 576–585PubMedCrossRef Carson P, Massie BM, McKelvie R, et al. The irbesartan in heart failure with preserved systolic function (I-PRESERVE) trial: rationale and design. J Card Fail 2005; 11: 576–585PubMedCrossRef
118.
Zurück zum Zitat Allen LA, O’Connor CM. Management of acute decompensated heart failure. CMAJ 2007; 176: 797–805PubMedCrossRef Allen LA, O’Connor CM. Management of acute decompensated heart failure. CMAJ 2007; 176: 797–805PubMedCrossRef
Metadaten
Titel
Economic Burden of Heart Failure in the Elderly
verfasst von
Dr Lawrence Liao
Larry A. Allen
David J. Whellan
Publikationsdatum
01.06.2008
Verlag
Springer International Publishing
Erschienen in
PharmacoEconomics / Ausgabe 6/2008
Print ISSN: 1170-7690
Elektronische ISSN: 1179-2027
DOI
https://doi.org/10.2165/00019053-200826060-00001

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