nach oben

Clinical Drug Investigation

Erschienen in:

01.04.2006 | Original Research Article

Prevention of Postoperative Nausea and Vomiting after Thyroidectomy

Combined Antiemetic Treatment with Dexamethasone and Ginger versus Dexamethasone Alone

verfasst von: Aybars Tavlan, Dr Sema Tuncer, Atilla Erol, Ruhiye Reisli, Gökhan Aysolmaz, Seref Otelcioglu

Erschienen in: Clinical Drug Investigation | Ausgabe 4/2006

Einloggen, um Zugang zu erhalten

Abstract

Background: The aim of this study was to compare the prophylactic effects of dexamethasone plus ginger and dexamethasone alone on postoperative nausea and vomiting (PONV) in patients undergoing thyroidectomy.

Methods: One hundred and twenty patients undergoing general anaesthesia for thyroidectomy were enrolled in this randomised, double-blind study. Patients received oral diazepam 10mg with either oral placebo (group I) or 0.5g of ginger (group II) as premedication 1 hour prior to surgery. Standard general anaesthetic techniques and postoperative analgesia were employed. Both group I and group II received intravenous dexamethasone 150 μg/kg immediately before the induction of anaesthesia. Data were recorded over a 24-hour observation period after surgery.

Results: In the dexamethasone-treated group, 14 patients experienced nausea, two patients retched, three patients vomited once, two patients vomited repeatedly, and 14 patients required a rescue antiemetic. In the dexamethasone-plus-gingertreated group, 12 patients experienced nausea, one patient retched, four patients vomited once, no patients vomited repeatedly, and 13 patients required a rescue antiemetic. Dexamethasone plus ginger did not significantly reduce nausea and vomiting compared with dexamethasone alone during the observation period.

Conclusion: In conclusion, the prophylactic combination of antiemetic treatment with dexamethasone and ginger was not clinically or statistically superior to dexamethasone alone in preventing PONV in patients undergoing thyroidectomy.

Wang JJ, Ho ST, Lee SC, et al. The prophylactic effect of dexamethasone on postoperative nausea and vomiting in women undergoing thyroidectomy: a comparison of droperidol with saline. Anesth Analg 1999; 89: 200–3PubMed

Fujii Y, Tanaka H. Comparison of granisetron and ramosetron for the prevention of nausea and vomiting after thyroidectomy. Clin Ther 2002; 24: 766–72PubMedCrossRef

Wang JJ, Ho ST, Lee SC, et al. The use of dexamethasone for preventing postoperative nausea and vomiting in females undergoing thyroidectomy: a dose-ranging study. Anesth Analg 2000; 91: 1404–7PubMedCrossRef

Henzi I, Wang JJ, Tzeng JJ, et al. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg 2000; 90: 186–94PubMedCrossRef

Fujii Y, Tanaka H, Kobayashi N. Granisetron/dexamethasone combination for the prevention of postoperative nausea and vomiting after thyroidectomy. Anaesth Intensive Care 2000; 28: 266–9PubMed

Haynes R. Adrenocorticotropic hormone: adrenocortical steroids and their synyhetic analogs-inhibitors of the synthesis and action of adrenocortical hormones. In: Goodman Gilman A, Gilman S, et al., editors. The pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990: 1447–8

Eberhart LH, Mayer R, Betz O, et al. Ginger does not prevent postoperative nausea and vomiting after laparoscopic surgery. Anesth Anaig 2003; 96: 995–8CrossRef

Willetts KE, Ekangaki A, Eden JA. Effect of a ginger extract on pregnancy-induced nausea: randomized controlled trial. Aust N Z J Obstet Gynacecol 2003; 43: 139–44CrossRef

Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anaesth 2000; 84: 367–71PubMedCrossRef

10.

Piper SN, Triem JG, Maleck W, et al. Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. Eur J Anaesthesiol 2001; 18: 251–6PubMed

11.

Watcha MF, White PF. Postoperative nausea and vomiting: its etiology, treatment and prevention. Anesthesiology 1992; 77: 162–84PubMedCrossRef

12.

Habib AS, Gan TJ. Evidence-based management of postoperative nausea and vomiting: a review. Can J Anaesth 2004; 51: 326–41PubMedCrossRef

13.

Tuncer S, Bariskaner H, Yosunkaya A, et al. Influence of dexamethasone on nausea and vomiting during patient-controlled analgesia with tramadol. Clin Drug Invest 2002; 22: 547–52CrossRef

14.

Splinter WM, Rhine EJ. Low dose ondansetron with dexamethasone more effectively decreases vomiting after strabismus surgery in children than does high dose ondansetron. Anesthesiology 1998; 88: 72–5PubMedCrossRef

15.

McKenzie R, Tantisira B, Karambelkar DJ, et al. Comparison of ondansetron with ondansetron plus dexamethasone in the prevention of postoperative nausea and vomiting. Anesth Analg 1994; 79: 961–94PubMedCrossRef

16.

Palazzo M, Evans R. Logistic regression analysis of fixed patients factors for postoperative sickness: a model for risk assessment. Br J Anaesth 1993; 70: 135–40PubMedCrossRef

17.

Bhattarai S, Tran VH, Duke CC. The stability of gingerol and shagaol in aqueous solutions. J Pharm Sci 2001; 90: 1658–64PubMedCrossRef

18.

Philips S, Ruggier R, Hutchinson SE. Zingiber offinale (ginger): an antiemetic for day case surgery. Anaesthesia 1993; 48: 715–7CrossRef

19.

Arfeen Z, Owen H, Plummer JL, et al. A double-blind randomised controlled trial of ginger for the prevention of postoperative nausea and vomiting. Anaesth Intensive Care 1995; 23: 449–52PubMed

20.

Bone ME, Wilkinson DJ, Young R, et al. Ginger root — new antiemetic: the effect of ginger root on postoperative nausea and vomiting after major gynaecological surgery. Anaesthesia 1990; 45: 669–71PubMedCrossRef

21.

Visalyaputra S, Petchpaisit N, Somcharoen K, et al. The efficacy of ginger root in the prevention of postoperative nausea and vomiting after outpatient gynaecological laparoscopy. Anaesthesia 1998; 53: 486–510CrossRef

22.

Bachon J. Ginger as an antiemetic: possible side effects due to its thromboxane synthetase activity. Anaesthesia 1991; 46: 705–6CrossRef

23.

Brunton LL. Drugs affecting gastrointestinal function. In: Hardman JG, Limbird LE, Moiinoff PB, et al. editors. Goodman and Gilman’s the pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill, 1996: 899–936

Titel: Prevention of Postoperative Nausea and Vomiting after Thyroidectomy
Combined Antiemetic Treatment with Dexamethasone and Ginger versus Dexamethasone Alone
verfasst von: Aybars Tavlan
Dr Sema Tuncer
Atilla Erol
Ruhiye Reisli
Gökhan Aysolmaz
Seref Otelcioglu
Publikationsdatum: 01.04.2006
Verlag: Springer International Publishing
Erschienen in: Clinical Drug Investigation / Ausgabe 4/2006
Print ISSN: 1173-2563
Elektronische ISSN: 1179-1918
DOI: https://doi.org/10.2165/00044011-200626040-00005

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2006

Antihypertensive Efficacy of Olmesartan Medoxomil and Candesartan Cilexetil in Achieving 24-Hour Blood Pressure Reductions and Ambulatory Blood Pressure Goals

Closer to an ‘Ideal Inhaler’ with the Easyhaler®

RETRACTED ARTICLE: Efficacy of Granisetron for the Treatment of Postoperative Nausea and Vomiting in Women Undergoing Breast Surgery

Treatment of Psoriasis Vulgaris with the Two-Compound Product Calcipotriol/Betamethasone Dipropionate followed by Different Formulations of Calcipotriol

Oral Ciprofloxacin Affects the Pharmacokinetics of Paracetamol in Saliva

Effect of Etidronic Acid on Arterial Calcification in Dialysis Patients