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01.01.2008 | Original Research Article

Efficacy of a Mucoadhesive Patch Compared with an Oral Solution for Treatment of Aphthous Stomatitis

verfasst von: Avner Shemer, Boaz Amichai, Henri Trau, Nir Nathansohn, Boaz Mizrahi, Prof. Abraham J. Domb

Erschienen in: Drugs in R&D | Ausgabe 1/2008

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Abstract

Objective: The purpose of this study was to evaluate the efficacy and tolerability of a mucoadhesive patch compared with a pain-relieving oral solution for the treatment of aphthous stomatitis.

Methods: Patients with active aphthous stomatitis were randomly treated either once a day with a mucoadhesive patch containing citrus oil and magnesium salts (n = 26) or three times a day with an oral solution containing benzocaine and compound benzoin tincture (n = 22). All patients were instructed to apply the medication until pain had resolved, and completed a questionnaire detailing multiple clinical parameters followed by an evaluation of the treatment.

Results: The mucoadhesive patch was found to be more effective than the oral solution in terms of healing time (mean ± SD: 36.0 ± 22.8 hours vs 134.7 ± 57.7, p < 0.001) and pain intensity after 12 and 24 hours (3.7 ± 2.8 vs 6.3 ± 2.6, p = 0.003, and 2.3 ± 2.7 vs 5.7 ± 2.5, p < 0.001, respectively). Local adverse effects 1 hour after treatment were significantly (p < 0.01) less frequent among the mucoadhesive patch patients compared with the oral solution patients.

Conclusions: The mucoadhesive patch was found to be significantly more effective and better tolerated than the oral solution in the treatment of aphthous stomatitis.

The use of trade names is for product identification purposes only and does not imply endorsement.

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Titel: Efficacy of a Mucoadhesive Patch Compared with an Oral Solution for Treatment of Aphthous Stomatitis
verfasst von: Avner Shemer
Boaz Amichai
Henri Trau
Nir Nathansohn
Boaz Mizrahi
Prof. Abraham J. Domb
Publikationsdatum: 01.01.2008
Verlag: Springer International Publishing
Erschienen in: Drugs in R&D / Ausgabe 1/2008
Print ISSN: 1174-5886
Elektronische ISSN: 1179-6901
DOI: https://doi.org/10.2165/00126839-200809010-00003

Springer Medizin

Abstract

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