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CNS Drugs

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01.08.2010 | Adis Drug Profile

Low-Dose Doxepin

In the Treatment of Insomnia

verfasst von: Juliane Weber, M. Asif A. Siddiqui, Antona J. Wagstaff, Paul L. McCormack

Erschienen in: CNS Drugs | Ausgabe 8/2010

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Abstract

Doxepin binds with high specificity and affinity to the histamine H₁ receptor compared with other receptors. Therefore, at low doses, doxepin selectively antagonises H₁ receptors, which is believed to promote the initiation and maintenance of sleep.

In three large, well designed, phase III trials in adult or elderly patients with chronic primary insomnia, oral, low-dose doxepin 3 or 6 mg once daily improved wake time after sleep onset, total sleep time and sleep efficiency to a significantly greater extent than placebo.

Significant between-group differences in polysomnographic sleep recordings that favoured low-dose doxepin were evident after a single administration of the drug. Other efficacy measures, including patient-reported sleep quality, also favoured low-dose doxepin over placebo.

Symptom control was maintained for up to 12 weeks of low-dose doxepin administration and there was no evidence of physical dependence or worsening insomnia after doxepin withdrawal.

Oral, low-dose doxepin 6 mg was also significantly more effective than placebo in a large, well designed trial modelling transient insomnia in healthy adults, according to polysomnographic recordings (e.g. in latency to persistent sleep).

Oral, low-dose doxepin was generally well tolerated in clinical trials.

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Titel: Low-Dose Doxepin
In the Treatment of Insomnia
verfasst von: Juliane Weber
M. Asif A. Siddiqui
Antona J. Wagstaff
Paul L. McCormack
Publikationsdatum: 01.08.2010
Verlag: Springer International Publishing
Erschienen in: CNS Drugs / Ausgabe 8/2010
Print ISSN: 1172-7047
Elektronische ISSN: 1179-1934
DOI: https://doi.org/10.2165/11200810-000000000-00000

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