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01.05.2012 | Leading Article

Management of Metastatic Castration-Resistant Prostate Cancer

Recent Advances

verfasst von: Deborah Mukherji, Andrew Eichholz, Professor Johann S. De Bono

Erschienen in: Drugs | Ausgabe 8/2012

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Abstract

Metastatic prostate cancer remains a considerable therapeutic challenge; however, advances in clinical research have resulted in five new treatments in the last 2 years. The immunotherapy sipuleucel-T, the cytotoxic cabazitaxel, the androgen biosynthesis inhibitor abiraterone acetate, the radioisotope al-pharadin and the anti-androgen MDV3100 have all been shown to improve overall survival in randomized phase III studies for patients with metastatic castration-resistant prostate cancer. The therapeutic strategies of targeting androgen-receptor signalling and other key intracellular pathways involved in tumour progression and treatment resistance are yielding promising results. Agents such as the dual vascular endothelial growth factor receptor/MET inhibitor cabozantinib, the clusterin inhibitor custirsen and the Src inhibitor dasatinib have shown encouraging results in phase II studies. Novel immunotherapeutics such as prostate-specific membrane antigen-directed therapy and the anti-cytotoxic T lymphocyte-associated receptor 4 (CTLA4) antibody ipilimumab are also under investigation. Optimal methods of treatment selection, combination and sequencing have yet to be determined.

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Titel: Management of Metastatic Castration-Resistant Prostate Cancer
Recent Advances
verfasst von: Deborah Mukherji
Andrew Eichholz
Professor Johann S. De Bono
Publikationsdatum: 01.05.2012
Verlag: Springer International Publishing
Erschienen in: Drugs / Ausgabe 8/2012
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI: https://doi.org/10.2165/11633360-000000000-00000

Springer Medizin

Abstract

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