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01.12.2014 | Research article | Ausgabe 1/2014 Open Access

BMC Cardiovascular Disorders 1/2014

Lipid, adipokine and ghrelin levels in myocardial infarction patients with insulin resistance

Zeitschrift:
BMC Cardiovascular Disorders > Ausgabe 1/2014
Autoren:
Olga Gruzdeva, Evgenya Uchasova, Ekaterina Belik, Yulia Dyleva, Ekaterina Shurygina, Olga Barbarash
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

OG was principal investigator, study co-ordinator and investigator, participated in all stages of recruitment of the patients and in analysis of the data, drafted and reviewed critically the manuscript. EU was study co-ordinator and investigator, participated in all stages of recruitment of the patients and in analysis of the data, drafted and reviewed critically the manuscript; EB and YD was study investigator, participated in all stages of recruitment of patients and reviewed critically the manuscript. OB was principal investigator. All other study investigators conducted the study and collected the data. All authors read and approved the final manuscript.

Abstract

Background

Insulin resistance (IR) is a risk factor for ischaemic heart disease and myocardial infarction (MI). IR often manifests in MI and is regarded as an independent predictor of in-hospital mortality, which can provide early risk stratification for recurrent acute coronary events.

Methods

The study enrolled 200 patients (130 males and 70 females aged 61.4 ± 1.12 years) diagnosed with ST elevation MI. At days 1 and 12 from the MI onset, IR levels and lipid profiles, as well as serum glucose, insulin, adipokine and ghrelin levels, were measured.

Results

Free fatty acid (FFA) levels had the most pronounced changes: IR patients had a 9-fold increase in FFA levels at day 1, and patients without IR had a 6-fold increase. Leptin levels at days 1 and 12, in IR patients were, on average, 1.5- and 2-fold higher compared to the controls and patients with no IR (р < 0.05). Leptin levels in IR patients were increased throughout the entire hospital stay. Resistin levels in IR patients were, on average, 1.4-fold higher throughout the entire hospital stay, while in non-IR patients, resistin levels were similar to the controls. Adiponectin levels in IR patients were decreased compared to the controls, while in patients with IR, they were similar to the controls. Both IR and non-IR MI patients had 3-fold and 3.7-fold lower ghrelin levels at day 1, respectively, compared to the controls. The correlation analysis showed a negative correlation between ghrelin and FFA (r = −0.48 р = 0.007), ghrelin and leptin (r = −0.4 р = 0.003), ghrelin and insulin (r = −0.54 р = 0.002), and ghrelin and glucose (r = −0.31 р = 0.002) in MI patients.

Conclusion

Dyslipidaemia, along with insulinaemia and glycaemia, is one of the most significant IR risk factors in the acute and early recovery phases of MI. Dyslipidaemia is characterised by a high FFA level; an imbalance of leptin, resistin, and adiponectin; and a deficiency of ghrelin in the acute and early recovery periods of MI. FFA and ghrelin can be used as promising molecular markers to stratify the risk of recurrent acute coronary events and diabetes mellitus in MI patients.
Literatur
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