Background
Femoral neck fractures potentially lead to catastrophic physical and functional impairment [
1‐
4]. The demand for total hip arthroplasty (THA), which is an exceedingly successful surgery for femoral neck fractures, has gradually climbed in the elderly [
1] and could increase by 174% by 2030 [
5]. The increase in demand may also be contributing to the escalated implant-related failure rate. Total hip arthroplasty with an uncemented or cemented femoral component (UTHA or CTHA) is a relatively common procedure for the treatment of femoral neck fractures [
6‐
8]. Prior studies [
6,
9,
10] have shown perioperative benefits of CTHA over UTHA are fewer complications and shorter recovery times, but these findings were based on studies with small sample sizes. Nevertheless, there remain concerns that longer-term outcomes of UTHA may not be as robust as those of CTHA, that UTHA increases the need for early revision (< 5 years) and that UTHA requires unnecessary interventions to maintain normal hip function [
8,
11]. The risks of early revision and reintervention, as well as the excessive expense associated with these supplementary procedures, could offset the primary benefit obtained from UTHA [
12,
13]. Furthermore, highly selective characteristics of the studied individuals tend to exist in previous studies [
6,
12,
14]. Hence, the findings in those studies could fail to reflect the actual situation.
To date, there is no direct comparison regarding long-term outcomes following UTHA or CTHA in the Asian population. Furthermore, there remain limited data regarding long-term reinterventions for problems following UTHA or CTHA, such as prosthetic loosening and periprosthetic fracture. In the present study, we used data from the South China Hip Arthroplasty Database to compare long-term outcomes for patients with femoral neck fracture (AO/OTA type 31B) treated with primary UTHA or CTHA.
Discussion
Our analysis provides evidence that CTHA was superior to UTHA because of the significantly increased HHS and distinctly reduced orthopaedic complication rate associated with CTHA in an Asian population with femoral neck fracture (AO/OTA type 31B). Moreover, the present analysis was conducted with data from a cohort representative of the “real world” practice.
In several randomised controlled trials [
6,
12,
14], UTHA tended to be associated with a higher prosthetic revision rate and moderately lower HHS in comparison with those of CTHA. Given this, the application of CTHA in individuals with femoral neck fractures could have a significant influence on postoperative complications. When analysing the impact of CTHA on clinical complications, we failed to detect an increased risk for unfavourable outcomes, particularly prosthetic revision and loosening. Furthermore, previous studies [
6,
9,
22] observed a distinctly low risk for CTHA-related complications. Although CTHA improves clinical outcomes, one safety concern is that interference with the cemented femoral component could promote the destabilisation of bone and cement components and thus increase the risk for complications, such as prosthetic loosening, prosthetic revision, periprosthetic fracture, dislocation, femur shaft fracture, hip pain, lower limb shortening and heterotopic ossification [
10,
23]. This is of specific concern, as undergoing a THA has been considered a potential risk factor for morbidity and mortality [
8,
13]. Moreover, prior reports have conceded THA is associated with increased complications in the treated individuals [
11,
24]. Early prosthesis revision is acknowledged as a key adverse event and has been the focus of several reports related to THA [
10]. Although a recently published assessment of CTHA and UTHA demonstrated improved safety profiles with UTHA, some of the studies have a relatively small sample size, which renders their conclusions unconvincing [
22,
25]. Although our study focuses on the early stages of follow-up and UTHA appears to be undifferentiated from CTHA regarding HHSs and complication rates, it will be of great consequence to determine whether resistance to bone microstructure occurs in the later stages of follow-up and, if so, by what mechanism [
12,
25].
Two recent meta-analyses indicated that CTHA was as effective, if not more so, than UTHA [
26,
27]. The improvement in HHS with CTHA was important, particularly since there were fewer early prosthetic revisions with CTHA than with UTHA [
28,
29]. Although a high complication rate and poor quality of life were associated with UTHA [
30], a rapid recovery process was observed, without significant differences in the HHSs at the first or second month after surgery. Because of the increasing complication rates, the ideal treatment strategy for femoral fracture is of concern. Prior randomised controlled studies [
25,
31] with long-term follow-up demonstrated that UTHA had an influence on the treatment outcomes with regards to the increased incidence of complications, such as loosening of prostheses. Despite the clear benefit of CTHA, a growing, but still very limited body of literature, has shown a distinctly higher rate of early revision after CTHA treatment among patients in some other medical centres [
14,
32].
There has always been an argument about the use of uncemented versus cemented femoral components in THA [
33]. Although UTHA and CTHA have gained enormous popularity in recent decades, experiencing rapid adoption, there remains no consensus on which device should be used for femoral neck fractures, and it could be a long time before consensus is reached [
34,
35]. Furthermore, the evidence based on the latest reports [
22,
36] regarding whether initial UTHA or CTHA is the optimal strategy is unclear. The principles behind CTHA and the low friction of metal-polyethylene are extremely important for the modification of joint surgery [
7]. However, long-term loosening is commonly deemed to be the main cause of CTHA failure [
8,
12]. To date, CTHA remains considered the gold standard for assessing other prosthetic surgeries, and early weight-bearing is easier to achieve following CTHA than following UTHA [
8,
9].
Several limitations should be acknowledged. First, selection bias seems impossible to avoid because a large number of patients were excluded. Furthermore, residual bias from confounding factors remains because some information was unavailable and therefore was excluded. Second, our analysis is a retrospective observational study with some problems inherent to the methodology. Confounders due to the research methods may have reduced the power to draw reliable conclusions, but well-matched cohorts rendered us able to draw conclusions that were irrespective of the baseline data. The purpose of our study was to compare the long-term clinical outcomes for patients with femoral neck fracture (AO/OTA type 31B) treated with primary unilateral UTHA or CTHA. It is important to emphasise that we cannot provide a comprehensive recommendation to further improve outcomes for all individuals undergoing CTHA based on the current results.
Conclusions
The results reported in this study support a growing body of evidence that CTHA is superior to UTHA in an Asian population with femoral neck fracture (AO/OTA type 31B). To date, controversy remains about the use of CTHA or UTHA, and the type of surgical approach used should be fully evaluated, along with the patient’s age, activity level, and life expectancy, with the aim of achieving the optimal clinical efficacy.
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