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01.11.2012 | Original Article

Long-term oral effects in patients treated with radiochemotherapy for head and neck cancer

verfasst von: Aline Lima da Silva Deboni, Adelmo José Giordani, Nilza Nelly Fontana Lopes, Rodrigo Souza Dias, Roberto Araujo Segreto, Siri Beier Jensen, Helena Regina Comodo Segreto

Erschienen in: Supportive Care in Cancer | Ausgabe 11/2012

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Abstract

Purpose

The purpose of this study is to assess the late oral complications and the role of salivary gland hypofunction in the severity of mucosal reaction in nonsurgical head and neck cancer patients, submitted to radiotherapy with or without chemotherapy.

Methods and materials

Five hundred fifteen charts from patients treated between 2005 and 2009 were reviewed, and 41 patients met the inclusion criteria. Salivary gland function was assessed using a simplified grading system (GSX) and sialometry. Late effects were assessed using the Common Toxicity Criteria (CTC Version 2.0).

Results

The average follow-up was 17.1 (4–51) months. A statistical correlation was found for whole salivary flow rates and the average CTC grades for the mucous membrane. Both unstimulated/stimulated whole salivary flow rates (<0.09 mL/min) were identified as potential risk factors (p < 0.05) and an independent predictor for late mucous membrane toxicity (≥grade 2). A significant correlation was also found between unstimulated salivary flow rates—GSX scores (p = 0.001) and CTC grades for salivary glands. Eighty-five percent of the patients were classified as suffering from salivary gland hypofunction, as well as 58.2 % considered dryness of the mouth the most debilitating complication.

Conclusions

Considering the late effects assessed, the salivary gland hypofunction was the most significant and received the highest morbidity graduation (grade 2/grade 3); xerostomia was also considered the most debilitating complication after treatment. Data show the role of salivary gland hypofunction in the severity of late mucous membrane complication.

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Titel: Long-term oral effects in patients treated with radiochemotherapy for head and neck cancer
verfasst von: Aline Lima da Silva Deboni
Adelmo José Giordani
Nilza Nelly Fontana Lopes
Rodrigo Souza Dias
Roberto Araujo Segreto
Siri Beier Jensen
Helena Regina Comodo Segreto
Publikationsdatum: 01.11.2012
Verlag: Springer-Verlag
Erschienen in: Supportive Care in Cancer / Ausgabe 11/2012
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-012-1418-7

Springer Medizin

Long-term oral effects in patients treated with radiochemotherapy for head and neck cancer