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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.06.2012 | Original Article

Longitudinal imaging of Alzheimer pathology using [¹¹C]PIB, [¹⁸F]FDDNP and [¹⁸F]FDG PET

verfasst von: Rik Ossenkoppele, Nelleke Tolboom, Jessica C. Foster-Dingley, Sofie F. Adriaanse, Ronald Boellaard, Maqsood Yaqub, Albert D. Windhorst, Frederik Barkhof, Adriaan A. Lammertsma, Philip Scheltens, Wiesje M. van der Flier, Bart N. M. van Berckel

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2012

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Abstract

Purpose

[¹¹C]PIB and [¹⁸F]FDDNP are PET tracers for in vivo detection of the neuropathology underlying Alzheimer’s disease (AD). [¹⁸F]FDG is a glucose analogue and its uptake reflects metabolic activity. The purpose of this study was to examine longitudinal changes in these tracers in patients with AD or mild cognitive impairment (MCI) and in healthy controls.

Methods

Longitudinal, paired, dynamic [¹¹C]PIB and [¹⁸F]FDDNP (90 min each) and static [¹⁸F]FDG (15 min) PET scans were obtained in 11 controls, 12 MCI patients and 8 AD patients. The mean interval between baseline and follow-up was 2.5 years (range 2.0–4.0 years). Parametric [¹¹C]PIB and [¹⁸F]FDDNP images of binding potential (BP_ND) and [¹⁸F]FDG standardized uptake value ratio (SUVr) images were generated.

Results

A significant increase in global cortical [¹¹C]PIB BP_ND was found in MCI patients, but no changes were observed in AD patients or controls. Subsequent regional analysis revealed that this increase in [¹¹C]PIB BP_ND in MCI patients was most prominent in the lateral temporal lobe (p < 0.05). For [¹⁸F]FDDNP, no changes in global BP_ND were found. [¹⁸F]FDG uptake was reduced at follow-up in the AD group only, especially in frontal, parietal and lateral temporal lobes (all p < 0.01). Changes in global [¹¹C]PIB binding (ρ = −0.42, p < 0.05) and posterior cingulate [¹⁸F]FDG uptake (ρ = 0.54, p < 0.01) were correlated with changes in Mini-Mental-State Examination score over time across groups, whilst changes in [¹⁸F]FDDNP binding (ρ = −0.18, p = 0.35) were not.

Conclusion

[¹¹C]PIB and [¹⁸F]FDG track molecular changes in different stages of AD. We found increased amyloid load in MCI patients and progressive metabolic impairment in AD patients. [¹⁸F]FDDNP seems to be less useful for examining disease progression.

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Titel: Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET
verfasst von: Rik Ossenkoppele
Nelleke Tolboom
Jessica C. Foster-Dingley
Sofie F. Adriaanse
Ronald Boellaard
Maqsood Yaqub
Albert D. Windhorst
Frederik Barkhof
Adriaan A. Lammertsma
Philip Scheltens
Wiesje M. van der Flier
Bart N. M. van Berckel
Publikationsdatum: 01.06.2012
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2012
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-012-2102-3

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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