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01.04.2015 | Research Article

Lung metastasis of pancreatic carcinoma is regulated by TGFβ signaling

verfasst von: Liqiang Song, Ping Wang, Yu Tian, De Chang, Kailong Li, Yongna Fan, Jing Shen, Hongzhen Du, Ruifang Mi, Xiaoxia Bian, Xianchao Tang

Erschienen in: Tumor Biology | Ausgabe 4/2015

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Abstract

The molecular regulation of the lung metastasis of pancreatic carcinoma (PCC) is not completely understood. Here, we show that the levels of phosphorylated SMAD3, ZEB1, ZEB2, Snail1, and Snail2 were significantly higher in PCC with lung metastasis than in PCC without lung metastasis. Overexpression of TGFβ1 enhanced the invasiveness of PCC cells, while inhibition of TGFβ1 decreased the invasiveness of PCC cells, which appeared to be conducted by activated TGFβ receptor signaling-induced upregulation of ZEB1, ZEB2, Snail1, and Snail2, suggesting a process of epithelial-mesenchymal transition (EMT). Taken together, our study provides evidence that TGFβ receptor signaling-induced EMT may be responsible for the increased PCC invasiveness to enhance its lung metastasis.

Han H, Von Hoff DD. Snapshot: pancreatic cancer. Cancer Cell. 2013;23:424–424 e421.CrossRefPubMedPubMedCentral

Willis BC, Borok Z. TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol. 2007;293:L525–34.CrossRefPubMed

Morrison CD, Parvani JG, Schiemann WP. The relevance of the TGF-beta paradox to EMT-MET programs. Cancer Lett. 2013;341:30–40.CrossRefPubMed

Heldin CH, Vanlandewijck M, Moustakas A. Regulation of EMT by TGFbeta in cancer. FEBS Lett. 2012;586:1959–70.CrossRefPubMed

Massague J. TGFbeta in cancer. Cell. 2008;134:215–30.CrossRefPubMedPubMedCentral

Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, et al. M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. Proc Natl Acad Sci U S A. 2014;111:E1211–20.CrossRefPubMedPubMedCentral

Yi JJ, Barnes AP, Hand R, Polleux F, Ehlers MD. TGF-beta signaling specifies axons during brain development. Cell. 2010;142:144–57.CrossRefPubMedPubMedCentral

Ewen ME, Sluss HK, Whitehouse LL, Livingston DM. TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell. 1993;74:1009–20.CrossRefPubMed

Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, et al. TGF-beta-foxo signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature. 2010;463:676–80.CrossRefPubMed

10.

Xiao X, Wiersch J, El-Gohary Y, Guo P, Prasadan K, Paredes J, et al. TGFbeta receptor signaling is essential for inflammation-induced but not beta-cell workload-induced beta-cell proliferation. Diabetes. 2013;62:1217–26.CrossRefPubMedPubMedCentral

11.

Harazono Y, Muramatsu T, Endo H, Uzawa N, Kawano T, Harada K, et al. miR-655 is an EMT-suppressive microRNA targeting ZEB1 and TGFBR2. PLoS One. 2013;8:e62757.CrossRefPubMedPubMedCentral

12.

Kiefel H, Bondong S, Pfeifer M, Schirmer U, Erbe-Hoffmann N, Schafer H, et al. EMT-associated up-regulation of L1cam provides insights into L1cam-mediated integrin signalling and NF-kappaB activation. Carcinogenesis. 2012;33:1919–29.CrossRefPubMed

13.

Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas. Int J Cancer. 1975;15:741–7.CrossRefPubMed

14.

Shi W, Yin J, Chen Z, Chen H, Liu L, Meng Z. Cyr61 promotes growth of pancreatic carcinoma via nuclear exclusion of p27. Tumour Biol 2014 in press. doi:10.1007/s13277-014-2423-x.

Titel: Lung metastasis of pancreatic carcinoma is regulated by TGFβ signaling
verfasst von: Liqiang Song
Ping Wang
Yu Tian
De Chang
Kailong Li
Yongna Fan
Jing Shen
Hongzhen Du
Ruifang Mi
Xiaoxia Bian
Xianchao Tang
Publikationsdatum: 01.04.2015
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 4/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-014-2834-8

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Lung metastasis of pancreatic carcinoma is regulated by TGFβ signaling

Abstract

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Abstract

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