Erschienen in:
11.06.2022 | Original Article
Magnetic resonance imaging of methotrexate-related lymphoproliferative disorder with a chief complaint of oral symptoms
verfasst von:
Ami Kuribayashi, Sakurako Kawashima, Kou Kayamori, Junichiro Sakamoto, Hiroshi Tomisato, Hiroshi Watanabe, Tohru Kurabayashi
Erschienen in:
Oral Radiology
|
Ausgabe 2/2023
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Abstract
Objectives
To determine the magnetic resonance imaging (MRI) features of methotrexate-related lymphoproliferative disorder (MTX-LPD) in the oral cavity of a patient with a chief complaint of oral symptoms.
Methods
We included six patients who visited our hospital between November 2014 and November 2019, histopathologically diagnosed with MTX-LPD. All images were examined using 3 T MRI and reviewed by two radiologists.
Results
Masses were detected in five cases; all masses demonstrated signal hypointensity and homogeneous signal hyperintensity on T1- and T2-weighted images with fat suppression. Homogeneous enhancement with fat suppression was evident on post-contrast T1-weighted imaging. We performed dynamic contrast-enhanced MRI in three cases and observed early enhancement with a low washout ratio pattern in all cases. Four patients underwent diffusion-weighted MRI and revealed low mean apparent diffusion coefficient (ADC) of 0.57 (range 0.5–0.65) × 10–3 mm2/s.
Conclusions
We reported on the imaging characteristics of six rare cases of MTX-LPD in the oral cavity. Homogeneous hyperintensity on fat-suppressed T2-weighted images and low ADC values are possible features of MTX-LPD. Moreover, MTX-LPD can be differentiated from other carcinomas in the oral cavity.