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Quality of Life Research

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Open Access 25.02.2019

Main and interactive effects of inflammation and perceived neighbourhood cohesion on psychological distress: results from a population-based study in the UK

verfasst von: Efstathios Papachristou, Eirini Flouri, Theodora Kokosi, Marta Francesconi

Erschienen in: Quality of Life Research | Ausgabe 8/2019

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Abstract

Purpose

Low neighbourhood cohesion and increased levels of inflammation are independent predictors of psychological distress. In this study we explored if they also interact to predict it.

Methods

Our sample was 9,393 adult participants of the UK Household Longitudinal Study (UKHLS), a large longitudinal household panel study in the UK. Inflammation was measured using C-reactive protein levels. Perceived neighbourhood cohesion was measured using a 13-item questionnaire. Psychological distress was measured with the General Health Questionnaire-12.

Results

Perceived neighbourhood cohesion and inflammation retained their significant main effects on psychological distress even after adjustment for confounders (age, gender, ethnicity, partner status, education, smoking status, obesity and urbanicity). The effect of neighbourhood cohesion was larger. However, we did not find evidence for an interactive association between the two.

Conclusions

Perceived neighbourhood cohesion was inversely related to psychological distress, over and above other important person- and neighbourhood-level characteristics. Inflammation was also associated with psychological distress, albeit less strongly. If these associations are causal, they suggest that promoting neighbourhood cohesion can alleviate some of the burden associated with psychological distress.

We also examined whether perceived neighbourhood cohesion and CRP interact not only between them but also with urbanicity to impact on GHQ. A fully adjusted regression model including the terms for the three 2-way interactions and the 3-way interaction between perceived neighbourhood cohesion, CRP and urbanicity showed that none of the interactions was statistically significant (p-values ranged from 0.13–0.99). Only perceived neighbourhood cohesion (OR 0.87, 95% CI 0.79–0.96, p = 0.004), but not CRP (OR 1.84, 95% CI 0.37–9.16, p = 0.46), retained a significant main effect on GHQ.

In the analytic sample fibrinogen correlated significantly with CRP (rho = 0.35, p < 0.01) but not GHQ (rho = 0.01, p > 0.05).

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Titel: Main and interactive effects of inflammation and perceived neighbourhood cohesion on psychological distress: results from a population-based study in the UK
verfasst von: Efstathios Papachristou
Eirini Flouri
Theodora Kokosi
Marta Francesconi
Publikationsdatum: 25.02.2019
Verlag: Springer International Publishing
Erschienen in: Quality of Life Research / Ausgabe 8/2019
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-019-02143-7

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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