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Erschienen in: Acta Neuropathologica 6/2013

01.12.2013 | Editorial

Making sense of the antisense transcripts in C9FTD/ALS

verfasst von: Peter K. Todd

Erschienen in: Acta Neuropathologica | Ausgabe 6/2013

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Excerpt

In medicine, Occam’s razor is employed to enforce diagnostic parsimony upon complicated cases. Stated simply, Occam’s razor says that the single disease that best accounts for all of a patient’s symptoms is likely to be the primary cause of all of them. In biomedical research, a similar logic is often applied, triggering searches for a single central pathogenic mechanism as the primary (or sole) pathway that causes a given disease. The rationale for this approach is clear: only when we know the one true cause of a disease can we know where to focus our efforts for therapeutic development. In this issue of Acta Neuropathologica, five new papers suggest that successful application of Occam’s razor to the recently described C9-associated frontotemporal dementia and amyotrophic lateral sclerosis (C9FTD/ALS) is going to be a challenge. …
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Metadaten
Titel
Making sense of the antisense transcripts in C9FTD/ALS
verfasst von
Peter K. Todd
Publikationsdatum
01.12.2013
Verlag
Springer Berlin Heidelberg
Erschienen in
Acta Neuropathologica / Ausgabe 6/2013
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-013-1201-y

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