nach oben

Journal of Assisted Reproduction and Genetics

Erschienen in:

01.06.2017 | Assisted Reproduction Technologies

Male chromosomal polymorphisms reduce cumulative live birth rate for IVF couples

verfasst von: Tianxiang Ni, Jing Li, Hong Chen, Yuan Gao, Xuan Gao, Junhao Yan, Zi-Jiang Chen

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 8/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Chromosomal polymorphisms are associated with infertility, but their effects on assisted reproductive outcomes are still quite conflicting, especially after IVF treatment. This study evaluated the role of chromosomal polymorphisms of different genders in IVF pregnancy outcomes.

Methods

Four hundred and twenty-five infertile couples undergoing IVF treatment were divided into three groups: 214 couples with normal chromosomes (group A, control group), 86 couples with female polymorphisms (group B), and 125 couples with male polymorphisms (group C). The pregnancy outcomes after the first and cumulative transfer cycles were analyzed, and the main outcome measures were live birth rate (LBR) after the first transfer cycle and cumulative LBR after a complete IVF cycle.

Results

Comparison of pregnancy outcomes after the first transfer cycle within group A, group B, and group C demonstrated a similar LBR as well as other rates of implantation, clinical pregnancy, early miscarriage, and ongoing pregnancy (P > 0.05). However, the analysis of cumulative pregnancy outcomes indicated that compared with group A, group C had a significantly lower LBR per cycle (80.4 vs 68.00%), for a rate ratio of 1.182 (95% CI 1.030 to 1.356, P = 0.01) and a significantly higher cumulative early miscarriage rate (EMR) among clinical pregnancies (7.2 vs 14.7%), for a rate ratio of 0.489 (95% CI 0.248 to 0.963, P = 0.035).

Conclusion

Couples with chromosomal polymorphisms in only male partners have poor pregnancy outcomes after IVF treatment manifesting as high cumulative EMR and low LBR after a complete cycle.

Nur mit Berechtigung zugänglich

Wyandt HE, Tonk VS. Human chromosome variation: heteromorphism and polymorphism. Berlin: Springer; 2011.

Madon PF, Athalye AS, Parikh FR. Polymorphic variants on chromosomes probably play a significant role in infertility. Reprod BioMed Online. 2005;11(6):726–32.CrossRefPubMed

Vulkova G. Chromosomal aberrations and chromosomal polymorphism in families with reproductive failure. Folia Med (Plovdiv). 1983;25(3):11–8.

Nakamura Y, Kitamura M, Nishimura K, Koga M, Kondoh N, Takeyama M, et al. Chromosomal variants among 1790 infertile men. Int J Urol. 2001;8(2):49–52.CrossRefPubMed

Minocherhomji S, Athalye AS, Madon PF, Kulkarni D, Uttamchandani SA, Parikh FR. A case-control study identifying chromosomal polymorphic variations as forms of epigenetic alterations associated with the infertility phenotype. Fertil Steril. 2009;92(1):88–95. doi:10.1016/j.fertnstert.2008.05.071.CrossRefPubMed

Mierla D, Stoian V. Chromosomal polymorphisms involved in reproductive failure in the Romanian population. Balkan J Med Genet. 2012;15(2):23–8. doi:10.2478/bjmg-2013-0003.PubMed

De la Fuente-Cortes BE, Cerda-Flores RM, Davila-Rodriguez MI, Garcia-Vielma C, De la Rosa Alvarado RM, Cortes-Gutierrez EI. Chromosomal abnormalities and polymorphic variants in couples with repeated miscarriage in Mexico. Reprod BioMed Online. 2009;18(4):543–8.CrossRefPubMed

Akbas H, Isi H, Oral D, Turkyilmaz A, Kalkanli-Tas S, Simsek S, et al. Chromosome heteromorphisms are more frequent in couples with recurrent abortions. Genet Mol Res. 2012;11(4):3847–51. doi:10.4238/2012.November.12.1.CrossRefPubMed

Dong Y, Li LL, Wang RX, Yu XW, Yun X, Liu RZ. Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of chromosome abnormalities or polymorphisms. Genet Mol Res. 2014;13(2):2849–56. doi:10.4238/2014.January.17.4.CrossRefPubMed

10.

Suganya J, Kujur SB, Selvaraj K, Suruli MS, Haripriya G, Samuel CR. Chromosomal abnormalities in infertile men from southern India. J Clin Diagn Res. 2015;9(7):GC05–10. doi:10.7860/jcdr/2015/14429.6247.PubMedPubMedCentral

11.

Hong Y, Zhou YW, Tao J, Wang SX, Zhao XM. Do polymorphic variants of chromosomes affect the outcome of in vitro fertilization and embryo transfer treatment? Hum Reprod. 2011;26(4):933–40. doi:10.1093/humrep/deq333.CrossRefPubMedPubMedCentral

12.

Guo T, Qin Y, Gao X, Chen H, Li G, Ma J, et al. The role of male chromosomal polymorphism played in spermatogenesis and the outcome of IVF/ICSI-ET treatment. Int J Androl. 2012;35(6):802–9. doi:10.1111/j.1365-2605.2012.01284.x.CrossRefPubMed

13.

Xu X, Zhang R, Wang W, Liu H, Liu L, Mao B, et al. The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI-ET cycles in a Chinese population. J Assist Reprod Genet. 2016;33(11):1481–6. doi:10.1007/s10815-016-0793-2.CrossRefPubMed

14.

Sahin FI, Yilmaz Z, Yuregir OO, Bulakbasi T, Ozer O, Zeyneloglu HB. Chromosome heteromorphisms: an impact on infertility. J Assist Reprod Genet. 2008;25(5):191–5. doi:10.1007/s10815-008-9216-3.CrossRefPubMedPubMedCentral

15.

Yakin K, Balaban B, Urman B. Is there a possible correlation between chromosomal variants and spermatogenesis? Int J Urol. 2005;12(11):984–9. doi:10.1111/j.1442-2042.2005.01185.x.CrossRefPubMed

16.

Liang J, Zhang Y, Yu Y, Sun W, Jing J, Liu R. Effect of chromosomal polymorphisms of different genders on fertilization rate of fresh IVF-ICSI embryo transfer cycles. Reprod BioMed Online. 2014;29(4):436–44. doi:10.1016/j.rbmo.2014.06.011.CrossRefPubMed

17.

Giglio S, Broman KW, Matsumoto N, Calvari V, Gimelli G, Neumann T, et al. Olfactory receptor-gene clusters, genomic-inversion polymorphisms, and common chromosome rearrangements. Am J Hum Genet. 2001;68(4):874–83. doi:10.1086/319506.CrossRefPubMedPubMedCentral

18.

Lissitsina J, Mikelsaar R, Varb K, Punab M. Cytogenetic study in infertile men. Ann Genet. 2003;46:185.

19.

Morales R, Lledo B, Ortiz JA, Ten J, Llacer J, Bernabeu R. Chromosomal polymorphic variants increase aneuploidies in male gametes and embryos. Syst Biol Reprod Med. 2016;62(5):317–24. doi:10.1080/19396368.2016.1212949.CrossRefPubMed

20.

Caglayan AO, Ozyazgan I, Demiryilmaz F, Ozgun MT. Are heterochromatin polymorphisms associated with recurrent miscarriage? J Obstet Gynaecol Res. 2010;36(4):774–6. doi:10.1111/j.1447-0756.2010.01207.x.CrossRefPubMed

21.

Yan J, Fan L, Zhao Y, You L, Wang L, Zhao H, et al. DYZ1 copy number variation, Y chromosome polymorphism and early recurrent spontaneous abortion/early embryo growth arrest. Eur J Obstet Gynecol Reprod Biol. 2011;159(2):371–4. doi:10.1016/j.ejogrb.2011.07.033.CrossRefPubMed

22.

Xiao Z, Zhou X, Xu W, Yang J. A preliminary study of the relationship between the long arm of the Y chromosome (Yqh+) and reproductive outcomes in IVF/ICSI-ET. Eur J Obstet Gynecol Reprod Biol. 2012;165(1):57–60. doi:10.1016/j.ejogrb.2012.07.004.CrossRefPubMed

23.

Pereza N, Crnjar K, Buretic-Tomljanovic A, Volk M, Kapovic M, Peterlin B, et al. Y chromosome azoospermia factor region microdeletions are not associated with idiopathic recurrent spontaneous abortion in a Slovenian population: association study and literature review. Fertil Steril. 2013;99(6):1663–7. doi:10.1016/j.fertnstert.2013.01.101.CrossRefPubMed

24.

Liu XH, Qiao J, Li R, Yan LY, Chen LX. Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm. J Assist Reprod Genet. 2013;30(6):813–9. doi:10.1007/s10815-013-0009-y.CrossRefPubMedPubMedCentral

25.

Ghorbian S, Saliminejad K, Sadeghi MR, Javadi GR, Kamali K, Amirjannati N, et al. The association between Y chromosome microdeletion and recurrent pregnancy loss. Iran Red Crescent Med J. 2012;14(6):358–62.PubMedPubMedCentral

26.

Nie H, Lu G. Long Y chromosome is not a fetal loss risk. J Assist Reprod Genet. 2011;28(2):151–6. doi:10.1007/s10815-010-9497-1.CrossRefPubMed

27.

Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, et al. DNA sequence and analysis of human chromosome 9. Nature. 2004;429(6990):369–74. doi:10.1038/nature02465.CrossRefPubMedPubMedCentral

28.

Garcia-Peiro A, Oliver-Bonet M, Navarro J, Abad C, Guitart M, Amengual MJ, et al. Sperm DNA integrity and meiotic behavior assessment in an infertile male carrier of a 9qh+++ polymorphism. J Biomed Biotechnol. 2011;2011:730847. doi:10.1155/2011/730847.CrossRefPubMed

29.

Kirkpatrick G, Chow V, Ma S. Meiotic recombination, synapsis, meiotic inactivation and sperm aneuploidy in a chromosome 1 inversion carrier. Reprod BioMed Online. 2012;24(1):91–100. doi:10.1016/j.rbmo.2011.09.013.CrossRefPubMed

Titel: Male chromosomal polymorphisms reduce cumulative live birth rate for IVF couples
verfasst von: Tianxiang Ni
Jing Li
Hong Chen
Yuan Gao
Xuan Gao
Junhao Yan
Zi-Jiang Chen
Publikationsdatum: 01.06.2017
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 8/2017
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-017-0951-1

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Ambulantisierung: Erste Erfahrungen mit dem Hybrid-DRG

02.05.2024 DCK 2024 Kongressbericht

Die Hybrid-DRG-Verordnung soll dazu führen, dass mehr chirurgische Eingriffe ambulant durchgeführt werden, wie es in anderen Ländern schon länger üblich ist. Die gleiche Vergütung im ambulanten und stationären Sektor hatten Niedergelassene schon lange gefordert. Aber die Umsetzung bereitet ihnen doch Kopfzerbrechen.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Harninkontinenz: Netz-Op. erfordert über lange Zeit intensive Nachsorge

30.04.2024 Harninkontinenz Nachrichten

Frauen mit Belastungsinkontinenz oder Organprolaps sind nach einer Netz-Operation keineswegs beschwerdefrei. Vielmehr scheint die Krankheitslast weiterhin hoch zu sein, sogar höher als von harninkontinenten Frauen, die sich nicht haben operieren lassen.

Welche Übungen helfen gegen Diastase recti abdominis?

30.04.2024 Schwangerenvorsorge Nachrichten

Die Autorinnen und Autoren einer aktuellen Studie aus Griechenland sind sich einig, dass Bewegungstherapie, einschließlich Übungen zur Stärkung der Bauchmuskulatur und zur Stabilisierung des Rumpfes, eine Diastase recti abdominis postpartum wirksam reduzieren kann. Doch vieles ist noch nicht eindeutig belegt.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2017

Selecting embryos with the highest implantation potential using data mining and decision tree based on classical embryo morphology and morphokinetics

Use of various gonadotropin and biosimilar formulations for in vitro fertilization cycles: results of a worldwide Web-based survey

Association between growth dynamics, morphological parameters, the chromosomal status of the blastocysts, and clinical outcomes in IVF PGS cycles with single embryo transfer

Human sperm Toll-like receptor 4 (TLR4) mediates acrosome reaction, oxidative stress markers, and sperm parameters in response to bacterial lipopolysaccharide in infertile men