nach oben

Erschienen in:

01.05.2012 | Brief report

Maternal and cord steroid sex hormones, angiogenic factors, and insulin-like growth factor axis in African-American preeclamptic and uncomplicated pregnancies

verfasst von: Jessica M. Faupel-Badger, Yuping Wang, Anne Cathrine Staff, S. Ananth Karumanchi, Frank Z. Stanczyk, Michael Pollak, Robert N. Hoover, Rebecca Troisi

Erschienen in: Cancer Causes & Control | Ausgabe 5/2012

Einloggen, um Zugang zu erhalten

Abstract

Background

A history of a preeclamptic pregnancy has been associated with subsequent increased risk of cardiovascular disease in the mother and decreased risk of breast cancer in both the mother and offspring. The concentrations of steroid sex hormones, angiogenic factors, and other proteins during pregnancy are important components of the in utero environment and may mediate the association of preeclampsia with later health outcomes. This study sought to compare an extensive profile of biological markers in both maternal and umbilical cord samples in preeclamptic and uncomplicated pregnancies of a predominantly African-American population.

Methods

Steroid sex hormones, angiogenic factors, and components of the insulin-like growth factor axis were measured in maternal and umbilical cord sera from 48 pregnancies complicated by preeclampsia and 43 uncomplicated pregnancies. Regression models estimated the associations of these markers with preeclampsia, after adjusting for maternal and gestational age.

Results

Concentrations of androgens (testosterone p = 0.06 and androstenedione p = 0.08) and the anti-angiogenic factors soluble fms-like kinase 1 (p = 0.004) and soluble endoglin (p = 0.004) were higher in the maternal circulation of women diagnosed with preeclampsia. These findings also were noted when the analyses were restricted to only African-American participants (77% of overall study population). Furthermore, among African-Americans, cord insulin-like growth factor-1 was lower in preeclamptic pregnancies than in controls.

Conclusions

The associations of maternal androgens and anti-angiogenic factors with preeclampsia are consistent with prior reports from predominantly Caucasian populations. Alterations in these analytes as well as other maternal and fetal biomarkers in preeclampsia could mediate the associations of preeclampsia with later health consequences.

Bellamy L, Casas JP, Hingorani AD, Williams DJ (2007) Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ 335:974PubMedCrossRef

Craici I, Wagner S, Garovic VD (2008) Preeclampsia and future cardiovascular risk: formal risk factor or failed stress test? Ther Adv Cardiovasc Dis 2:249–259PubMedCrossRef

Powe CE, Levine RJ, Karumanchi SA (2011) Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation 123:2856–2869PubMedCrossRef

Kajantie E, Eriksson JG, Osmond C, Thornburg K, Barker DJ (2009) Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort study. Stroke 40:1176–1180PubMedCrossRef

Tenhola S, Rahiala E, Halonen P, Vanninen E, Voutilainen R (2006) Maternal preeclampsia predicts elevated blood pressure in 12-year-old children: evaluation by ambulatory blood pressure monitoring. Pediatr Res 59:320–324PubMedCrossRef

Innes KE, Byers TE (1999) Preeclampsia and breast cancer risk. Epidemiology 10:722–732PubMedCrossRef

Troisi R, Potischman N, Hoover RN (2007) Exploring the underlying hormonal mechanisms of prenatal risk factors for breast cancer: a review and commentary. Cancer Epidemiol Biomarkers Prev 16:1700–1712PubMedCrossRef

Acromite MT, Mantzoros CS, Leach RE, Hurwitz J, Dorey LG (1999) Androgens in preeclampsia. Am J Obstet Gynecol 180:60–63PubMedCrossRef

Young BC, Levine RJ, Karumanchi SA (2010) Pathogenesis of preeclampsia. Annu Rev Pathol 5:173–192

10.

Gingery A, Bahe EL, Gilbert JS (2009) Placental ischemia and breast cancer risk after preeclampsia: tying the knot. Expert Rev Anticancer Ther 9:671–681PubMedCrossRef

11.

Key T, Appleby P, Barnes I, Reeves G (2002) Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 94:606–616PubMedCrossRef

12.

Ray A, Cleary MP (2010) Leptin as a potential therapeutic target for breast cancer prevention and treatment. Expert Opin Ther Targets 14:443–451

13.

Vona-Davis L, Rose DP (2009) Angiogenesis, adipokines and breast cancer. Cytokine Growth Factor Rev 20:193–201PubMedCrossRef

14.

Fauser BC, Laven JS, Tarlatzis BC, Moley KH, Critchley HO, Taylor RN et al. (2011) Sex steroid hormones and reproductive disorders: impact on women’s health. Reprod Sci 18:702–712

15.

Walker JJ (2000) Pre-eclampsia. Lancet 356:1260–1265PubMedCrossRef

16.

Wang A, Rana S, Karumanchi SA (2009) Preeclampsia: the role of angiogenic factors in its pathogenesis. Physiology (Bethesda) 24:147–158CrossRef

17.

Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP et al (2006) Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355:992–1005PubMedCrossRef

18.

Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF et al (2004) Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350:672–683PubMedCrossRef

19.

Levine RJ, Qian C, Maynard SE, Yu KF, Epstein FH, Karumanchi SA (2006) Serum sFlt1 concentration during preeclampsia and mid trimester blood pressure in healthy nulliparous women. Am J Obstet Gynecol 194:1034–1041PubMedCrossRef

20.

Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S et al (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111:649–658PubMed

21.

Rana S, Karumanchi SA, Levine RJ, Venkatesha S, Rauh-Hain JA, Tamez H et al (2007) Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia. Hypertension 50:137–142PubMedCrossRef

22.

Romero R, Nien JK, Espinoza J, Todem D, Fu W, Chung H et al (2008) A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med 21:9–23PubMedCrossRef

23.

Staff AC, Braekke K, Harsem NK, Lyberg T, Holthe MR (2005) Circulating concentrations of sFlt1 (soluble fms-like tyrosine kinase 1) in fetal and maternal serum during pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 122:33–39PubMedCrossRef

24.

Thadhani R, Mutter WP, Wolf M, Levine RJ, Taylor RN, Sukhatme VP et al (2004) First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab 89:770–775PubMedCrossRef

25.

Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM et al (2006) Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 12:642–649PubMedCrossRef

26.

Flegal KM, Carroll MD, Ogden CL, Curtin LR (2010) Prevalence and trends in obesity among US adults, 1999–2008. JAMA 303:235–241

27.

Knuist M, Bonsel GJ, Zondervan HA, Treffers PE (1998) Risk factors for preeclampsia in nulliparous women in distinct ethnic groups: a prospective cohort study. Obstet Gynecol 92:174–178PubMedCrossRef

28.

Tanaka M, Jaamaa G, Kaiser M, Hills E, Soim A, Zhu M et al (2007) Racial disparity in hypertensive disorders of pregnancy in New York State: a 10-year longitudinal population-based study. Am J Public Health 97:163–170PubMedCrossRef

29.

Tucker MJ, Berg CJ, Callaghan WM, Hsia J (2007) The Black-White disparity in pregnancy-related mortality from 5 conditions: differences in prevalence and case-fatality rates. Am J Public Health 97:247–251PubMedCrossRef

30.

Henderson BE, Bernstein L, Ross RK, Depue RH, Judd HL (1988) The early in utero oestrogen and testosterone environment of blacks and whites: potential effects on male offspring. Br J Cancer 57:216–218PubMedCrossRef

31.

Salamalekis E, Bakas P, Vitoratos N, Eleptheriadis M, Creatsas G (2006) Androgen levels in the third trimester of pregnancy in patients with preeclampsia. Eur J Obstet Gynecol Reprod Biol 126:16–19PubMedCrossRef

32.

Troisi R, Potischman N, Roberts JM, Ness R, Crombleholme W, Lykins D et al (2003) Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies. Int J Epidemiol 32:455–460PubMedCrossRef

33.

Zhang J, Masciocchi M, Lewis D, Sun W, Liu A, Wang Y (2008) Placental anti-oxidant gene polymorphisms, enzyme activity, and oxidative stress in preeclampsia. Placenta 29:439–443PubMedCrossRef

34.

Vatten LJ, Eskild A, Nilsen TI, Jeansson S, Jenum PA, Staff AC (2007) Changes in circulating level of angiogenic factors from the first to second trimester as predictors of preeclampsia. Am J Obstet Gynecol 196(239):e1–e6PubMed

35.

Erez O, Romero R, Espinoza J, Fu W, Todem D, Kusanovic JP et al (2008) The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age. J Matern Fetal Neonatal Med 21:279–287PubMedCrossRef

36.

Troisi R, Vatten L, Hoover RN, Roberts JM, Cole BF, Potischman N (2006) Maternal androgen and estrogen concentrations are not associated with blood pressure changes in uncomplicated pregnancies. Cancer Epidemiol Biomarkers Prev 15:2013–2015PubMedCrossRef

37.

Vatten LJ, Odegard RA, Nilsen ST, Salvesen KA, Austgulen R (2002) Relationship of insulin-like growth factor-I and insulin-like growth factor binding proteins in umbilical cord plasma to preeclampsia and infant birth weight. Obstet Gynecol 99:85–90PubMedCrossRef

38.

Xue F, Michels KB (2007) Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence. Lancet Oncol 8:1088–1100PubMedCrossRef

39.

Fryar CD, Hirsch R, Eberhardt MS, Yoon SS, Wright JD (2010) Hypertension, high serum total cholesterol, and diabetes: racial and ethnic prevalence differences in U.S. adults, 1999–2006. NCHS Data Brief 1–8

40.

Samadi AR, Mayberry RM, Zaidi AA, Pleasant JC, McGhee N Jr, Rice RJ (1996) Maternal hypertension and associated pregnancy complications among African-American and other women in the United States. Obstet Gynecol 87:557–563PubMedCrossRef

41.

Vatten LJ, Forman MR, Nilsen TI, Barrett JC, Romundstad PR (2007) The negative association between pre-eclampsia and breast cancer risk may depend on the offspring’s gender. Br J Cancer 96:1436–1438PubMed

Titel: Maternal and cord steroid sex hormones, angiogenic factors, and insulin-like growth factor axis in African-American preeclamptic and uncomplicated pregnancies
verfasst von: Jessica M. Faupel-Badger
Yuping Wang
Anne Cathrine Staff
S. Ananth Karumanchi
Frank Z. Stanczyk
Michael Pollak
Robert N. Hoover
Rebecca Troisi
Publikationsdatum: 01.05.2012
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 5/2012
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-9934-9

Neu im Fachgebiet Onkologie

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Springer Medizin

Maternal and cord steroid sex hormones, angiogenic factors, and insulin-like growth factor axis in African-American preeclamptic and uncomplicated pregnancies