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Osteoporosis International

Erschienen in:

01.03.2014 | Review

Maternal vitamin D status in pregnancy and offspring bone development: the unmet needs of vitamin D era

verfasst von: S. N. Karras, P. Anagnostis, E. Bili, D. Naughton, A. Petroczi, F. Papadopoulou, D. G. Goulis

Erschienen in: Osteoporosis International | Ausgabe 3/2014

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Abstract

Data from animal and human studies implicate maternal vitamin D deficiency during pregnancy as a significant risk factor for several adverse outcomes affecting maternal, fetal, and child health. The possible associations of maternal vitamin D status and offspring bone development comprise a significant public health issue. Evidence from randomized trials regarding maternal vitamin D supplementation for optimization of offspring bone mass is lacking. In the same field, data from observational studies suggest that vitamin D supplementation is not indicated. Conversely, supplementation studies provided evidence that vitamin D has beneficial effects on neonatal calcium homeostasis. Nevertheless, a series of issues, such as technical difficulties of current vitamin D assays and functional interplay among vitamin D analytes, prohibit arrival at safe conclusions. Future studies would benefit from adoption of a gold standard assay, which would unravel the functions of vitamin D analytes. This narrative review summarizes and discusses data from both observational and supplementation studies regarding maternal vitamin D status during pregnancy and offspring bone development.

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Titel: Maternal vitamin D status in pregnancy and offspring bone development: the unmet needs of vitamin D era
verfasst von: S. N. Karras
P. Anagnostis
E. Bili
D. Naughton
A. Petroczi
F. Papadopoulou
D. G. Goulis
Publikationsdatum: 01.03.2014
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 3/2014
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-013-2468-5

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