Background
Base damage to p53
The stress response
Intrinsically mutable bases
Predicting base mutability in vivo
Results and discussion
A | C | G | T | |
---|---|---|---|---|
Total number of all mutations in 240 nt (6662) | 865 | 1875 |
3375
| 547 |
Percent of total | 13.0% | 28.1% |
50.7%
| 8.2% |
Number of lung mutations in 240 nt (875) | 126 | 198 |
484
| 67 |
Percent of lung | 14.4% | 22.6% |
55.3%
| 7.7% |
Difference in total mutations compared to lung mutations | +1.4% | -5.5% |
+4.6%
| -0.5% |
A | C | T | |
---|---|---|---|
Total G mutations including lung (3375) |
2082
| 351 |
942
|
Percent of total |
61.7%
| 10.4% |
27.9%
|
Lung G mutations (484) |
153
| 74 |
257
|
Percent of lung |
31.6%
| 15.3% |
53.1%
|
Difference in total G mutations due to the presence of lung G mutations
|
-30.1%
| +4.9% |
+25.2%
|
A | G | T | |
---|---|---|---|
Total C mutations including lung (1875) | 157 | 187 | 1531 |
Percent of total | 8.4% | 10.0% | 81.6% |
Lung C mutations (198) | 21 | 31 | 146 |
Percent of lung | 10.6% | 15.7% | 73.7% |
Difference in total C mutations due to the presence of lung C mutations | +2.2% | +5.7% | -7.9% |
A | C | G | T | |
---|---|---|---|---|
Total number of all mutations in 240 nt (6662) | 865 |
1875
|
3375
| 547 |
Percent of total | 13.0% |
28.1%
|
50.7%
| 8.2% |
Number of colon mutations in 240 nt (651) | 42 |
260
|
317
| 32 |
Percent of colon | 6.4% |
40.0%
|
48.7%
| 4.9% |
Difference in total mutations compared to colon mutations | -6.6% |
+11.9%
|
-2.0%
| -3.3% |
A | C | T | |
---|---|---|---|
Total G mutations including colon (3375) |
2082
| 351 |
942
|
Percent of total |
61.7%
| 10.4% |
27.9%
|
Colon G mutations (317) |
257
| 19 |
41
|
Percent of colon |
81.1%
| 6.0% |
12.9%
|
Difference in total G mutations due to the presence of colon G mutations
|
+19.4%
| -4.4% |
-15.0%
|
A | G | T | |
---|---|---|---|
Total C mutations including colon (1875) | 157 | 187 |
1531
|
Percent of total | 8.4% | 10.0% |
81.6%
|
Colon C mutations (260) | 8 | 10 |
242
|
Percent of colon | 3.1% | 3.8% |
93.1%
|
Difference in total C mutations due to the presence of colon C mutations
| -5.3% | -6.2% |
+11.5%
|
A | C | G | T | |
---|---|---|---|---|
Total number of all mutations in 15 nt (3292) | 225 | 1195 |
1857
| 15 |
Percent of total | 6.8% | 36.3% |
56.4%
| 0.5% |
Number of lung mutations in 15 nt (407) | 26 | 107 |
273
| 1 |
Percent of lung | 6.4% | 26.3% |
67.1%
| 0.2% |
Difference in total mutations compared to lung mutations | -0.4% | -10.0% |
+10.7%
| -0.3% |
A | C | T | |
---|---|---|---|
Total G mutations including lung (1857) |
1214
| 107 |
536
|
Percent of total |
65.3%
| 5.8% |
28.9%
|
Lung G mutations (273) |
66
| 34 |
173
|
Percent of lung |
24.2%
| 12.4% |
63.4%
|
Difference in total G mutations due to the presence of lung G mutations
|
-41.1%
| +6.6% |
+34.5%
|
A | G | T | |
---|---|---|---|
Total C mutations including lung (1195) | 17 | 49 | 1129 |
Percent of total | 1.4% | 4.1% | 94.5% |
Lung C mutations (107) | 3 | 9 | 95 |
Percent of lung | 2.8% | 8.4% | 88.8% |
Difference in total C mutations due to the presence of lung C mutations | +1.4% | +4.3% | -5.7% |
A | C | G | T | |
---|---|---|---|---|
Total number of mutations in 4 nt (1775) | 0 | 728 |
1047
| 0 |
Percent of total | 0 | 41.0% |
59.0%
| 0 |
Number of lung mutations in 4 nt (187) | 0 | 63 |
124
| 0 |
Percent of lung | 0 | 33.7% |
66.3%
| 0 |
Difference in total mutations compared to lung mutations | 0 | -7.3% |
+7.3%
| 0 |
A | C | T | |
---|---|---|---|
Total G mutations including lung (1047) |
863
| 31 |
153
|
Percent of total |
82.4%
| 3.0% |
14.6%
|
Lung G mutations (124) |
46
| 9 |
69
|
Percent of lung |
37.1%
| 7.3% |
55.6%
|
Difference in total G mutations due to the presence of lung mutations
|
-45.3%
| +4.3% |
+41.0%
|
A | G | T | |
---|---|---|---|
Total C mutations including lung (728) | 11 | 21 | 696 |
Percent of total | 1.5% | 2.9% | 95.6% |
Lung mutations (63) | 3 | 2 | 58 |
Percent of lung | 4.8% | 3.2% | 92.1% |
Difference in total C mutations due to the presence of lung C mutations | +3.3% | +0.3% | -3.5% |