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Journal of Interventional Cardiac Electrophysiology

Erschienen in:

15.06.2016

Median nerve stimulation reduces ventricular arrhythmias induced by dorsomedial hypothalamic stimulation

verfasst von: Shuang Zhao, Min Tang, Kexin Yuan, Jingli Gu, Jun Yu, Xiaoyang Long, Miaomiao Liu, Ji-Min Cao, Shu Zhang

Erschienen in: Journal of Interventional Cardiac Electrophysiology | Ausgabe 3/2016

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Abstract

Background

This study tested the hypothesis that median nerve stimulation (MNS) prevents ventricular arrhythmias (VAs) induced by dorsomedial hypothalamus stimulation (DMHS) and investigated the electrophysiological mechanisms underlying the anti-arrhythmic effects of MNS by recording left stellate ganglion activity (LSGA).

Methods

Eighteen rabbits were anesthetized, the median nerve was anchored by stimulating electrodes, and a bipolar electrode was implanted into the LSG to record nerve activity. The DMH was stimulated to induce arrhythmia. All animals underwent six repetitions of DMHS (30 s). The 18 rabbits were divided into the following 3 groups: a control group, which underwent only DMHS (n = 6); an MNS group, which underwent MNS during both the third and fourth DMHS repetitions (n = 6); and an LSGA-recording group, for which LSGA was recorded at baseline, immediately following DMHS and again immediately following MNS and DMHS (n = 6).

Results

Repeated DMHS-induced multiple VAs, in the rabbits. Compared with the DMHS-only group, the concurrent administration of MNS during DMHS significantly reduced the incidence of VAs (7 ± 3 and 9 ± 2 beats for the third and fourth DMHS + MNS repetitions vs. 29 ± 8 and 27 ± 9 beats for the first two DMHS repetitions, p < 0.05). The total duration of the abnormal discharges of the LSG (ADLSG) following MNS and DMHS was significantly reduced compared with that of the DMHS-only group (40 ± 18 vs. 14 ± 6 s, p < 0.05).

Conclusion

MNS reduced VAs induced by DMHS, which is thought to be mediated through suppressing of ADLSG.

New and noteworthy

Median nerve electrical stimulation prevented ventricular arrhythmias induced by DMHS through the mechanism of suppressing abnormal discharges of left stellate ganglion.

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Titel: Median nerve stimulation reduces ventricular arrhythmias induced by dorsomedial hypothalamic stimulation
verfasst von: Shuang Zhao
Min Tang
Kexin Yuan
Jingli Gu
Jun Yu
Xiaoyang Long
Miaomiao Liu
Ji-Min Cao
Shu Zhang
Publikationsdatum: 15.06.2016
Verlag: Springer US
Erschienen in: Journal of Interventional Cardiac Electrophysiology / Ausgabe 3/2016
Print ISSN: 1383-875X
Elektronische ISSN: 1572-8595
DOI: https://doi.org/10.1007/s10840-016-0150-5

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Median nerve stimulation reduces ventricular arrhythmias induced by dorsomedial hypothalamic stimulation

Abstract

Background

Methods

Results

Conclusion

New and noteworthy

Neu im Fachgebiet Kardiologie

Das Risiko für Vorhofflimmern in der Bevölkerung steigt

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Beutel versus Maschine: Beste Beatmungstechnik bei Herzstillstand gesucht

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Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

New and noteworthy

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