Erschienen in:
25.03.2016 | Neuro-Images
Megalencephalic leukoencephalopathy with subcortical cysts
verfasst von:
Sanela Zukić, Osman Sinanović, Svjetlana Mujagić, Lejla Zonić, Larisa Kovačević
Erschienen in:
Acta Neurologica Belgica
|
Ausgabe 4/2016
Einloggen, um Zugang zu erhalten
Excerpt
The classic phenotype of megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterized by early-onset macrocephaly, combined with mildly gross motor developmental delay and seizures, gradual onset of ataxia, spasticity, sometimes extrapyramidal findings, and usually late onset of mild mental deterioration. The disease was recognised independently in India and the Netherlands, and also know as van der Knaap–Singhal disease [
1,
2]. …