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Erschienen in: Breast Cancer Research 6/2012

01.12.2012 | Viewpoint

MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expression

verfasst von: Sven Rottenberg, Jos Jonkers

Erschienen in: Breast Cancer Research | Ausgabe 6/2012

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Abstract

Lack of eradication of disseminated breast cancer by chemotherapy is a central clinical problem. Even tumors that show substantial shrinkage after drug treatment frequently relapse and eventually become refractory to all drugs available. The mechanisms underlying this lack of eradication are largely undefined and it is therefore difficult to develop curative strategies using systemic anti-cancer therapy. In a recent article low DUSP4 expression was reported to activate RAS-ERK signaling in residual breast cancer after neoadjuvant chemotherapy. This may be a druggable characteristic because MEK inhibition increases docetaxel sensitivity in a xenograft model.
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Metadaten
Titel
MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expression
verfasst von
Sven Rottenberg
Jos Jonkers
Publikationsdatum
01.12.2012
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 6/2012
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3327

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