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20.07.2017 | Original Article

Men Experience Higher Risk of Pneumonia and Death After Intracerebral Hemorrhage

verfasst von: Sandro Marini, Andrea Morotti, Umme K. Lena, Joshua N. Goldstein, Steven M. Greenberg, Jonathan Rosand, Christopher D. Anderson

Erschienen in: Neurocritical Care | Ausgabe 1/2018

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Abstract

Background

Infectious complications worsen outcome after intracerebral hemorrhage (ICH). We investigated the impact of sex on post-ICH infections and mortality.

Methods

Consecutive ICH patients (admitted to a single hospital between 1994 and 2015) were retrospectively assessed via chart review to ascertain the following in-hospital infections: urinary tract infection (UTI), pneumonia, and sepsis. Adjusted logistic regression was performed to identify associations between sex, infection, and mortality at 90 days.

Results

Two thousand and four patients were investigated, 1071 (53.7%) males. Men were more likely to develop pneumonia (21.9 vs 15.5% p < 0.001) and sepsis (3.4 vs 1.6%, p = 0.009), whereas women had higher risk of UTI (19.9 vs 11.7% p < 0.001). Multivariate analyses confirmed association between male sex and pneumonia (Odds Ratio (OR) 1.37, 95% confidence interval (CI) 1.08–1.74, p = 0.011). Male sex (OR 1.40; CI 1.07–1.85; p = 0.015) and infection (OR 1.56; CI 1.11–1.85; p = 0.011) were independently associated with higher 90-day mortality.

Conclusions

Types and rates of infection following ICH differ by sex. Male sex independently increases pneumonia risk, which subsequently increases 90-day mortality. Sex-specific preventive strategies to reduce the risk of these complications may be one strategy to improve ICH outcomes.

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Titel: Men Experience Higher Risk of Pneumonia and Death After Intracerebral Hemorrhage
verfasst von: Sandro Marini
Andrea Morotti
Umme K. Lena
Joshua N. Goldstein
Steven M. Greenberg
Jonathan Rosand
Christopher D. Anderson
Publikationsdatum: 20.07.2017
Verlag: Springer US
Erschienen in: Neurocritical Care / Ausgabe 1/2018
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-017-0431-6

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