Background
Methods
Study selection
Data abstraction
Ranking
Results and discussion
Included independent studies
First author (reference) | Year | Lung cancer patients | Differentially expressed miRNAs | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Origin | Period | Cancer type | Clinical Stage | No. of collected tissue samples (cancer/normal) | Platform | Cut-off criteria | Total | Up-regulated features | Down-regulated features | ||
Boeri [19] | 2011 | Italy | Jun 2000 to Jun 2006 | Lung cancer | Satge I to IV (Stage I 60%) | 52 (28/24) | The miRNA microarray (Ohio State University, version 2.0) | P < 0.001 | 56 | 6† | 4† |
Dacic [20] | 2010 | USA (Pittsburgh) | NR | ADC | NR | 12 (6/6) | FlexmiR human microRNA pool (Version 8, Exiqon, Vedbaek, Denmark) | FC > 20 | 7 | 4 | 3 |
Gao [21] | 2010 | China (Jiangsu, First Affiliated Hospital of Nanjing Medical University) | Apr 2008 to Sep 2008 | NSCLC | NR | 16 (8/8) | miRCURY™ LNA microRNA Arrays (version 10.0, Exiqon, Vedbaek, Denmark) | FC > 2, P < 0.05 | 27 | 9 | 18 |
Apr 2008 | SCC [Ref 33] | NR | 8 (4/4) | FC > 2 | 31 | 7 | 23 | ||||
Jang [22] | 2012 | USA (Minnesota) | Jan 1997 to Sep 2008 | ADC | Stage I to IV (Stage I 68.0%) | 206 (103/103) | Illumina MicroRNA Profiling | FC > 1.5, P < 0.01, DR < 0.05 | 20 | 10 | 10 |
Ma [23] | 2011 | China (Zhejiang) | NR | NSCLC (SCC:3; ADC:3) | Stage I to IV (Stage I 16.7%) | 12 (6/6) | Illuminia Technologies “humanMI_V2” | FDR <0.1 | 1 | 1 | 0 |
Raponi [24] | 2009 | USA (Michigan) | Oct 1991 to Jul 2002 | SCC | Stage I to IV (Stage I 55%) | 71 (61/10) | Ambion mirVana Bioarray (version 2.0) | Signal intensity (log2) >6 in at least one group | 15 | 13 | 2 |
Seike [25] | 2009 | USA (Baltimore: 15; Minnesota:7); Japan (Hamamatsu: 6) | 2000 to 2004 | NSCLC (ADC around 78%) | Stage I to IV (Stage I 75%) | 56 (28/28) | The miRNA microarray (Ohio State University, version 3.0) | P < 0.01, FDR <0.15 | 18 | 5 | 13 |
Tan [26] | 2011 | China (Beijing) | 2000 to 2002 | SCC | NR | 68 (34/34) | CapitalBio platform (CapitalBio Corp.) | Significance analysis of microarray | 22 | 12 | 10 |
Võsa [27] | 2011 | Estonia (Tartu) | 2002 to 2008 | NSCLC (SCC:18; ADC:20) | Stage I/II (Stage I 92%) | 65 (38/27) | Illumina MicroRNA Profiling BeadChip | FC > 2, P < 0.01 | 60 | 31 | 29 |
Wang [28] | 2011 | China (Jiangsu, Nanjing Chest Hospital) | 2006 to 2008 | NSCLC (SCC:7; ADC:16) | NR | 46 (23/23) | μParaflo microfluidic chip technology (Atactic Technologies, Houston, TX, USA) | FC > 5, P < 0.01 | 40 | 27 | 13 |
Xing [29] | 2010 | USA (Baltimore) | Mar 2000 to Jun 2003 | SCC | Stage I | 30 (15/15) | GeneChipR miRNA Array (Affymetrix, Santa Clara, CA, USA) | FC > 1.5, P < 0.01 | 25 | 7 | 18 |
Yanaihara [30] | 2006 | USA (Baltimore) | 1990 to 1999 | NSCLC (SCC:39; ADC:65,) | Stage I to IV (Stage I 62.5%) | 208 (104/104) | The miRNA microarray Chip (TJU version 1.1) | P < 0.001 | 43 | 15 | 28 |
SCC | 78 (39/39) | 16 | 10 | 6 | |||||||
ADC | 130 (65/65) | 17 | 5 | 12 | |||||||
Yang [31] | 2010 | China (Shaanxi) | NR | SCC | NR | 6 (3/3) | miRCURY™ LNA array (version 10.0, Exiqon, Vedbaek, Denmark) | FC > 1.5, P < 0.05 | 9 | 2 | 7 |
Yu [32] | 2010 | USA (Baltimore) | NR | ADC | Stage I | 40 (20/20) | Taqman human miRNA array A (System Biosciences, Mountain View, CA) | FC > 1.5, P < 0.01 | 20 | 11 | 9 |
Differentially expressed miRNAs
miRNA namea | No. of studies with same direction (reference) | No. of tissue samples tested | Subset of studies with fold change | |||
---|---|---|---|---|---|---|
No. of studies | No. of tissue samples tested | Mean fold change | Range | |||
miR-210 | 9 (19,22,24,25,26,27,29,30,32) | 796 | 6 | 449 | 2.65 | 1.51 - 5.10 |
miR-21 | 7 (19,21,25,28,29,30,32) | 448 | 6 | 240 | 4.39 | 1.74 - 13.60 |
miR-182 | 6 (22,24,26,27,28,32) | 496 | 4 | 357 | 6.34 | 1.85 - 19.00 |
miR-31 | 6 (21,22,26,27,29,32) | 425 | 5 | 357 | 2.89 | 1.58 - 4.80 |
miR-205 | 5 (26,27,28,29,30) | 417 | 3 | 141 | 23.20 | 2.99 - 54.30 |
miR-200b | 5 (19,25,26,28,32) | 262 | 4 | 194 | 3.69 | 1.30 - 9.80 |
miR-183 | 4 (22,24,27,28) | 388 | 3 | 317 | 5.94 | 2.11 - 11.60 |
miR-203 | 3 (24,26,30) | 347 | 0 | - | - | - |
miR-196a | 3 (22,27,28) | 317 | 3 | 317 | 37.50 | 2.10 - 101.80 |
miR-708 | 3 (22,27,29) | 301 | 3 | 301 | 3.20 | 1.85 - 5.50 |
miR-92b | 3 (27,28,32) | 151 | 3 | 151 | 3.71 | 1.54 - 6.80 |
miR-193b | 3 (21,26,27) | 149 | 2 | 81 | 4.68 | 2.56 - 6.80 |
miR-106a | 2 (24,30) | 279 | 0 | - | - | - |
miR-21* | 2 (22,27) | 271 | 2 | 271 | 2.23 | 2.16 - 2.30 |
miR-135b | 2 (21,22) | 222 | 2 | 222 | 2.29 | 2.28 - 2.31 |
miR-96 | 2 (22,23) | 218 | 2 | 218 | 171.56 | 2.30 - 340.81 |
miR-17-5p | 2 (24,27) | 136 | 1 | 65 | 3.80 | - |
miR-20b | 2 (24,28) | 117 | 1 | 46 | 5.70 | - |
miR-18a | 2 (26,28) | 114 | 1 | 46 | 7.80 | - |
miR-200a | 2 (24,32) | 111 | 1 | 40 | 1.86 | - |
miR-93 | 2 (24,32) | 111 | 1 | 40 | 1.68 | - |
miR-130b | 2 (26,32) | 108 | 1 | 40 | 1.57 | - |
miR-200c | 2 (24,29) | 101 | 1 | 30 | 1.66 | - |
miR-375 | 2 (28,32) | 86 | 2 | 86 | 5.35 | 2.89 - 7.80 |
miR-20a | 2 (20,24) | 83 | 0 | - | - | - |
miR-18b | 2 (20,26) | 80 | 0 | - | - | - |
miRNA namea | No. of studies with same direction (reference) | Total number of tissue samples tested | Subset of studies with fold change | |||
---|---|---|---|---|---|---|
No. of studies | Total number of tissue samples tested | Mean fold change | Range | |||
miR-126 | 10 (19,21,25,26,27, 28,29,30,31,32) | 587 | 8 | 311 | 0.33 | 0.00 - 0.69 |
miR-30a | 8 (19,21,25,26,27,28,29,31) | 339 | 7 | 271 | 0.36 | 0.04 - 0.61 |
miR-451 | 6 (19,21,25,27,28,29) | 265 | 6 | 265 | 0.37 | 0.01 - 0.53 |
miR-486-5p | 5 (19,22,26,27,28) | 437 | 4 | 369 | 0.39 | 0.13 - 0.53 |
miR-30d | 5 (21,25,28,29,31) | 154 | 5 | 154 | 0.34 | 0.08 - 0.57 |
miR-145 | 4 (26,28,30,32) | 362 | 2 | 86 | 0.23 | 0.09 - 0.38 |
miR-143 | 4 (21,28,30,32) | 310 | 3 | 102 | 0.33 | 0.13 - 0.59 |
miR-139-5p | 3 (22,27,29) | 301 | 3 | 301 | 0.55 | 0.40 - 0.64 |
miR-126* | 3 (21,25,30) | 280 | 2 | 72 | 0.33 | 0.20 - 0.45 |
miR-140-3p | 3 (26,27,28) | 179 | 2 | 111 | 0.29 | 0.17 - 0.42 |
miR-138 | 3 (25,26,32) | 164 | 2 | 96 | 0.64 | 0.56 - 0.72 |
miR-30b | 3 (25,28,29) | 132 | 3 | 132 | 0.41 | 0.11 - 0.58 |
miR-486 | 3 (25,29,32) | 126 | 3 | 126 | 0.44 | 0.34 - 0.53 |
miR-101 | 3 (21,27,31) | 87 | 3 | 87 | 0.34 | 0.24 - 0.48 |
miR-125a | 2 (24,30) | 279 | 0 | - | - | - |
miR-198 | 2 (27,30) | 273 | 1 | 65 | 0.25 | - |
miR-144* | 2 (22,27) | 271 | 2 | 271 | 0.31 | 0.14 - 0.48 |
miR-140 | 2 (30,32) | 248 | 1 | 40 | 0.66 | - |
miR-218 | 2 (22,32) | 246 | 2 | 246 | 0.61 | 0.60 - 0.62 |
miR-32 | 2 (20,30) | 220 | 0 | - | - | - |
miR-338-3p | 2 (26,27) | 133 | 1 | 65 | 0.20 | - |
miR-99a | 2 (27,28) | 111 | 2 | 111 | 0.31 | 0.20 - 0.42 |
miR-195 | 2 (26,29) | 98 | 1 | 30 | 0.53 | - |
miR-497 | 2 (26,29) | 98 | 1 | 30 | 0.66 | - |
miR-30c | 2 (25,29) | 86 | 2 | 86 | 0.58 | 0.54 - 0.61 |
miR-130a | 2 (21,27) | 81 | 2 | 81 | 0.46 | 0.45 - 0.46 |
miR-16 | 2 (28,29) | 76 | 2 | 76 | 0.37 | 0.18 - 0.57 |
miR-139 | 2 (29,32) | 70 | 2 | 70 | 0.53 | 0.49 - 0.58 |
miRNA namea | Direction of expression | Reference | Total number of tissue samples tested | Mean fold change |
---|---|---|---|---|
miR-224 | ↑ | 24,27 | 136 | 3.4 |
↓ | 30 | 208 | - | |
miR-9 | ↑ | 22,27 | 271 | 8.59 |
↓ | 30 | 208 | - | |
miR-150 | ↑ | 30 | 208 | - |
↓ | 28,32 | 86 | 0.38 | |
miR-219-1 | ↑ | 19 | 52 | 1.6 |
↓ | 30 | 208 | - | |
miR-125a-5p | ↑ | 31 | 6 | 1.56 |
↓ | 26,29 | 98 | 0.62 | |
miR-429 | ↑ | 26 | 68 | - |
↓ | 29 | 30 | 0.50 | |
miR-24-2* | ↑ | 21 | 16 | 2.33 |
↓ | 27 | 65 | 0.5 |
Direction of expression | miRNA namea | No. of studies with same direction (reference) | Total number of tissue samples tested | Subset of studies with fold change | |||
---|---|---|---|---|---|---|---|
No. of studies | Total number of tissue samples tested | Mean fold change | Range | ||||
Up-regulated | miR-210 | 4 (24,26,29,30) | 247 | 1 | 30 | 2.37 | - |
miR-203 | 3 (24,26,30) | 217 | 0 | - | - | - | |
miR-205 | 3 (26,29,30) | 176 | 1 | 30 | 2.99 | - | |
miR-21 | 3 (29,30,33) | 116 | 2 | 38 | 2.53 | 1.74 - 3.31 | |
miR-31 | 3 (26,29,33) | 106 | 2 | 38 | 4.42 | 1.58 - 7.26 | |
miR-182 | 2 (24,26) | 139 | 0 | - | - | - | |
miR-200c | 2 (24,29) | 101 | 1 | 30 | 1.66 | - | |
miR-18a | 2 (26,33) | 76 | 1 | 8 | 2.24 | - | |
Down-regulated | miR-126 | 4 (26,29,31,33) | 112 | 3 | 44 | 0.18 | 0.00 - 0.42 |
miR-30a | 4 (26,29,31,33) | 112 | 3 | 44 | 0.28 | 0.11 - 0.53 | |
miR-30d | 3 (29,31,33) | 44 | 3 | 44 | 0.33 | 0.22 - 0.54 | |
miR-195 | 2 (26,29) | 98 | 1 | 30 | 0.53 | - | |
miR-497 | 2 (26,29) | 98 | 1 | 30 | 0.66 | - | |
miR-126* | 2 (30,33) | 86 | 1 | 8 | 0.16 | - | |
miR-143 | 2 (30,33) | 86 | 1 | 8 | 0.24 | - | |
miR-145 | 2 (26,33) | 76 | 1 | 8 | 0.48 | - | |
miR-451 | 2 (29,33) | 38 | 2 | 38 | 0.37 | 0.22 - 0.53 | |
miR-30b | 2 (29,33) | 38 | 2 | 38 | 0.50 | 0.48 - 0.53 | |
miR-101 | 2 (31,33) | 14 | 2 | 14 | 0.34 | 0.29 - 0.39 |
Direction of expression | miRNA name | No. of studies with same direction (reference) | Total number of tissue samples tested | Subset of studies with fold change | |||
---|---|---|---|---|---|---|---|
No. of studies | Total number of tissue samples tested | Mean fold change | Range | ||||
Up-regulated | miR-210 | 3 (22,30,32) | 376 | 2 | 246 | 1.96 | 1.75 - 2.17 |
miR-182 | 2 (22,32) | 246 | 2 | 246 | 2.03 | 1.85 - 2.22 | |
miR-31 | 2 (22,32) | 246 | 2 | 246 | 1.83 | 1.60 - 2.05 | |
miR-21 | 2 (30,32) | 170 | 1 | 40 | 2.56 | - | |
Down-regulated | miR-218 | 2 (22,32) | 246 | 2 | 246 | 0.61 | 0.60 - 0.62 |
miR-145 | 2 (30,32) | 170 | 1 | 40 | 0.38 | - | |
miR-126 | 2 (30,32) | 170 | 1 | 40 | 0.46 | - |