Background
Results
Multivariate data analysis of bio-fluids
Bio-fluid | Normalization | n | Number of components | R2X | Q2 (cum) |
---|---|---|---|---|---|
Bile | + | 11 | 1 | 0.57 | 0.36 |
Bile | -a | 11 | 2 | 0.40 | 0.37 |
Urine | + | 11 | 3 | 0.57 | -0.17 |
Urine | - | 11 | 2 | 0.39 | 0.12 |
Plasma | + | 110 | 10 | 0.97 | 0.74 |
Plasma | - | 110 | 10 | 0.95 | 0.91 |
Bile
Plasma
Compound | Observed δ, ppm | Clone | Control | ||||
---|---|---|---|---|---|---|---|
Alanine | 1.48 | 7.7 | ± | 0.5 | 6.8 | ± | 0.2 |
Choline | 3.21 | 16 | ± | 1.2 | 19 | ± | 2.0 |
Creatine | 3.92 | 3.1 | ± | 0.4 | 5.2 | ± | 0.7 |
Glutamate | 2.45 | 8.2 | ± | 0.2 | 7.5 | ± | 0.1 |
Lactate | 4.11 | 26 | ± | 4.7 | 15 | ± | 2.0 |
Lipid | 5.30 | 18.5 | ± | 0.9 | 22 | ± | 1.2 |
VLDL/LDL | 0.85 | 64 | ± | 4.6 | 77 | ± | 3.5 |
VLDL/LDL | 1.25 | 89 | ± | 5.2 | 109 | ± | 3.4 |
Effect of cloning on inter-individual variation
Variance | ||||||
---|---|---|---|---|---|---|
Peak number | Biofluid | Observed δ, ppm | Signal range | Clone | Control | v clone/v control |
1
| Bile | 0.62 | 87 - 102 | 5, 98 | 39.1 | 0.15 |
4
| Bile | 2.75 | 2.9 - 14.7 | 1.60 | 0.89 | 1.80 |
7
| Bile | 3.45 | 8.5 - 13.5 | 0.60 | 5.82 | 0.048a |
15
| Bile | 7.80 | 13.8 - 18.0 | 0.19 | 1.26 | 0.15 |
Bile | 7.98 | 1.8 - 4.9 | 0.57 | 2.15 | 0.26 | |
5
| Bile | 3.07 | 5.9 - 16.8 | 7.03 | 12.5 | 0.56 |
6, 12
| Bile | 4.30 | 3.7 - 8.5 | 0.94 | 0.74 | 1.27 |
4.42 | 0.5 - 3.8 | 0.049 | 0.036 | 1.38 | ||
3.25 | 12 - 53 | 15.2 | 7.05 | 2.16 | ||
23
| Plasma | 1.91 (s) | 0.005 - 0.05 | 5.40E-5 | 4.47E-5 | 1.21 |
21
| Plasma | 1.47 (d) | 0.006 - 0.1 | 0.00038 | 0.00037 | 1.02 |
33
| Plasma | 4.04 (s) | 0 - 0.03 | 2.77E-5 | 4.38E-5 | 0.63 |
20
| Plasma | 4.10 (q) | 0.03 - 0.7 | 0.013 | 0.017 | 0.78 |
27
| Plasma | 2.36 (s) | 0.003 - 0.04 | 4.54E-5 | 3.37E-5 | 1.35 |
34
| Plasma | 7.18 (d) | 0.003 - 0.03 | 3.12E-5 | 3.32E-5 | 0.94 |
18
| Plasma | 1.03 (d) | 0.004 - 0.3 | 0.0018 | 0.00038 | 4.58a |
21
| Urine | 1.48 (d) | 0.82 - 7.44 | 2.2 | 2.5 | 0.87 |
47
| Urine | 5.39 (s) | 1.89 - 31.4 | 112 | 53 | 2.11 |
33
| Urine | 3.04 (s) | 44 - 497 | 2.4E4 | 6.5E3 | 3.75 |
Urine | 4.05 (s) | 31 - 349 | 1.2E4 | 3.2E3 | 3.69 | |
45
| Urine | 7.84 (d) | 3.6 - 40 | 138 | 61 | 2.26a |
7.55 (t) | 3.7 - 47 | 185 | 67 | 2.85a | ||
3.97 (m) | 8.0 - 87 | 524 | 178 | 2.94a | ||
7.64 (t) | 8.1 - 28 | 64 | 19 | 3.44a | ||
36
| Urine | 0.94 (d) | 2.8 - 18 | 23 | 14 | 1.61 |
37
| Urine | 1.36 (s) | 2.9 - 11 | 7.2 | 4.0 | 1.80 |
44
| Urine | 7.37 (m) | 1.8 - 17 | 5.7 | 30.1 | 0.19 |
46
| Urine | 7.23 (d) | 2.2 - 68 | 547 | 181 | 3.02 |
Urine | 7.06 (d) | 0.7 - 60 | 514 | 146 | 3.52 | |
49
| Urine | 5.08 (d) | 0.0 - 22.1 | 79 | 15 | 5.20 |
48
| Urine | 5.78 | 78 - 643 | 2.0E4 | 1.2E4 | 1.62 |