nach oben

Indian Journal of Hematology and Blood Transfusion

Erschienen in:

22.09.2015 | Case Report

Methimazole Induced Total Myeloid Aplasia with Delayed Recovery Despite Granulocyte Colony Stimulating Factor (G-CSF): Marrow Progenitor Recovery Kinetics

verfasst von: Tania Sarker, Bülent Özgönenel, Manisha Gadgeel, Steven Buck, Amita Adhikari, Yaddanapudi Ravindranath

Erschienen in: Indian Journal of Hematology and Blood Transfusion | Sonderheft 1/2016

Einloggen, um Zugang zu erhalten

Abstract

An eighteen-year-old female with Graves thyrotoxicosis presented with methimazole-induced agranulocytosis and total myeloid aplasia. The bone marrow at presentation showed complete absence of myeloid precursors and striking plasmacytosis. 16 days later, myeloid precursors were still absent morphologically; however bone marrow flow cytometry and cell culture detected an improvement in myelogenesis, which was soon followed by clinical recovery of agranulocytosis. Neutrophil recovery was delayed until day 22 after cessation of methimazole despite G-CSF use, consistent with a direct toxic effect on committed myeloid cells. Our findings suggest that cell culture and flow cytometric evaluation of bone marrow myeloid progenitors can be used as a guide to anticipate neutrophil recovery.

McGavack T, Chevalley J (1954) Untoward hematologic responses to the antithyroid compounds. Am J Med 17(1):36–40CrossRefPubMed

Takata K, Kubota S, Fukata S, Kudo T, Nishihara E, Ito M, Amino N, Miyauchi A (2009) Methimazole-induced agranulocytosis in patients with Graves’ disease is more frequent with an initial dose of 30 mg daily than with 15 mg daily. Thyroid 19(6):559–563. doi:10.1089/thy.2008.0364 CrossRefPubMed

Nayak B, Burman K (2006) Thyrotoxicosis and thyroid storm. Endocrinol Metab Clin North Am 35(4):663–686. doi:10.1016/j.ecl.2006.09.008 CrossRefPubMed

Cooper DS, Daniels GH, Ridgeway EC (1984) Agranulocytosis and dose of methimazole. Ann Intern Med 101(2):283CrossRefPubMed

Dai WX, Zhang JD, Zhan SW, Xu BZ, Jin H, Yao Y, Xin WC, Bai Y (2002) Retrospective analysis of 18 cases of antithyroid drug (ATD)-induced agranulocytosis. Endocr J 49(1):29–33CrossRefPubMed

Honda M (2011) Successful treatment of methimazole-induced severe aplastic anemia by granulocyte colony-stimulating factor, methylprednisolone, and cyclosporin. ISRN endocrinol 2011:732623. doi:10.5402/2011/732623 CrossRefPubMedPubMedCentral

Cooper DS (2005) Antithyroid drugs. New Engl J Med 352(9):905–917. doi:10.1056/NEJMra042972 CrossRefPubMed

Sun MT, Tsai CH, Shih KC (2009) Antithyroid drug-induced agranulocytosis. J Chin Med Assoc 72(8):438–441. doi:10.1016/S1726-4901(09)70402-2 CrossRefPubMed

Yamamoto A, Katayama Y, Tomiyama K, Hosoai H, Hirata F, Kimura F, Fujita K, Yasuda H (2004) Methimazole-induced aplastic anemia caused by hypocellular bone marrow with plasmacytosis. Thyroid 14(3):231–235. doi:10.1089/105072504773297911 CrossRefPubMed

10.

Mutharasan P, Oatis W, Kwaan H, Molitch M (2012) Delayed anithyroid drug-induced agranulocytosis. Endocr Pract 18(4):e69–e72. doi:10.4158/EP11339.CR CrossRefPubMed

11.

Murphy MF, Chapman JF, Metcalfe P, Waters AH (1985) Antibiotic-induced neutropenia. Lancet 2(8467):1306–1307CrossRefPubMed

12.

Salama A, Schutz B, Kiefel V, Breithaupt H, Mueller-Eckhardt C (1989) Immune-mediated agranulocytosis related to drugs and their metabolites: mode of sensitization and heterogeneity of antibodies. Br J Haematol 72(2):127–132CrossRefPubMed

13.

Douer D, Eisenstein Z (1988) Methimazole-induced agranulocytosis: growth inhibition of myeloid progenitor cells by the patient’s serum. Eur J Haematol 40(1):91–94CrossRefPubMed

14.

Tajiri J, Noguchi S, Okamura S, Morita M, Tamaru M, Murakami N, Niho Y (1993) Granulocyte colony-stimulating factor treatment of antithyroid drug-induced granulocytopenia. Arch Intern Med 153(4):509–514CrossRefPubMed

15.

Minamitani K, Oikawa J, Wataki K, Kashima K, Hoshi M, Inomata H, Ota S (2011) A report of three girls with antithyroid drug-induced agranulocytosis; retrospective analysis of 18 cases aged 15 years or younger reported between 1995 and 2009. Clin Pediatr Endocrinol 20(2):39–46. doi:10.1297/cpe.20.39 CrossRefPubMedPubMedCentral

16.

Tamai H, Mukuta T, Matsubayashi S, Fukata S, Komaki G, Kuma K, Kumagai LF, Nagataki S (1993) Treatment of methimazole-induced agranulocytosis using recombinant human granulocyte colony-stimulating factor (rhG-CSF). J Clin Endocrinol Metab 77(5):1356–1360PubMed

17.

Thomas ED, Storb R, Clift RA, Fefer A, Johnson L, Neiman PE, Lerner KG, Glucksberg H, Buckner CD (1975) Bone-marrow transplantation (second of two parts). New Engl J Med 292(17):895–902. doi:10.1056/NEJM197504242921706 CrossRefPubMed

18.

Josol CV, Buenaluz-Sedurante M, Sandoval MA, Castillo G (2010) Successful treatment of methimazole-induced severe aplastic anaemia in a diabetic patient with other co-morbidities. BMJ Case Rep. doi:10.1136/bcr.05.2010.2993 PubMedPubMedCentral

19.

Thomas D, Moisidis A, Tsiakalos A, Alexandraki K, Syriou V, Kaltsas G (2008) Antithyroid drug-induced aplastic anemia. Thyroid 18(10):1043–1048. doi:10.1089/thy.2008.0097 CrossRefPubMed

20.

Stuijver DJ, van Zaane B, Romualdi E, Brandjes DP, Gerdes VE, Squizzato A (2012) The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: a systematic review and meta-analysis. Thromb Haemost 108(6):1077–1088. doi:10.1160/TH12-07-0496 CrossRefPubMed

21.

Erem C (2009) Coagulation and fibrinolysis in thyroid dysfunction. Endocrine 36(1):110–118. doi:10.1007/s12020-009-9185-z CrossRefPubMed

22.

Erem C (2011) Thyroid disorders and hypercoagulability. Semin Thromb Hemost 37(1):17–26. doi:10.1055/s-0030-1270067 CrossRefPubMed

23.

Yang J, Zhong J, Xiao XH, Zhou LZ, Chen YJ, Liu JH, Cao RX, Wen GB (2013) The relationship between bone marrow characteristics and the clinical prognosis of antithyroid drug-induced agranulocytosis. Endocr J 60(2):185–189CrossRefPubMed

Titel: Methimazole Induced Total Myeloid Aplasia with Delayed Recovery Despite Granulocyte Colony Stimulating Factor (G-CSF): Marrow Progenitor Recovery Kinetics
verfasst von: Tania Sarker
Bülent Özgönenel
Manisha Gadgeel
Steven Buck
Amita Adhikari
Yaddanapudi Ravindranath
Publikationsdatum: 22.09.2015
Verlag: Springer India
Erschienen in: Indian Journal of Hematology and Blood Transfusion / Ausgabe Sonderheft 1/2016
Print ISSN: 0971-4502
Elektronische ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-015-0595-1

Springer Medizin

Methimazole Induced Total Myeloid Aplasia with Delayed Recovery Despite Granulocyte Colony Stimulating Factor (G-CSF): Marrow Progenitor Recovery Kinetics

Abstract

Neu im Fachgebiet Onkologie

Erhöhte Mortalität bei postpartalem Brustkrebs

Hypertherme Chemotherapie bietet Chance auf Blasenerhalt

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

Bessere Prognose mit links- statt rechtsseitigem Kolon-Ca.

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Sonderheft 1/2016

Transfusion-Associated Graft-Versus-Host Disease with a Non-fatal Course

Accidental Poisoning Resulting in Severe Methemoglobinemia in a 14-year-old Girl

Glioblastoma Multiforme in a Post Allogeneic Stem Cell Transplant Patient. A Case Report and Literature Review of Post Transplant Neurological Tumors

Prevalence and Viral Load of Human Parvovirus B19 (B19V) Among Blood Donors in South-East Brazil

Anemia and Thrombocytopenia in New H5N6 Influenza: Existed or not?

A Case of Dasatinib-Induced Hemorrhagic Colitis Diagnosed by the Lymphocyte Transformation Test in a Chronic Myeloid Leukemia Patient

Neu im Fachgebiet Onkologie

Erhöhte Mortalität bei postpartalem Brustkrebs

Hypertherme Chemotherapie bietet Chance auf Blasenerhalt

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

Bessere Prognose mit links- statt rechtsseitigem Kolon-Ca.

Update Onkologie