Erschienen in:
01.12.2014 | Research Article
MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2
verfasst von:
Shujun Feng, Wenjing Pan, Ye Jin, Jianhua Zheng
Erschienen in:
Tumor Biology
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Ausgabe 12/2014
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Abstract
Ovarian cancer (OC) is a major cancer-related mortality among women. Recent studies suggest that many microRNAs (miRNAs) were dysregulated and involved in tumorigenesis of OC. The present study investigated the role of miR-25 in the development and progression of OC. The expression of miR-25 was increased in OC tissues and cell lines. Inhibition of miR-25 remarkably suppressed proliferation, migration, and invasion of OC cells. Large tumor suppressor 2 (LATS2), a tumor suppressor, was confirmed to be a direct target of miR-25 in OC cells. Moreover, restoration of LATS2 significantly attenuated the oncogenic effects of miR-25. Together, our data suggest an oncogenic role of miR-25 in OC and a potentially novel diagnostic and therapeutic target for OC treatment.