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Tumor Biology

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13.01.2016 | Original Article

miR-421 is a diagnostic and prognostic marker in patients with osteosarcoma

verfasst von: Shuguang Zhou, Bing Wang, Jun Hu, Yucheng Zhou, Mengzhen Jiang, Mingyu Wu, Liming Qin, Xuming Yang

Erschienen in: Tumor Biology | Ausgabe 7/2016

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Abstract

MicroRNAs (miRNAs) are a new class of prognostic and diagnostic biomarkers for many cancers. Recent studies have shown that miRNAs are highly stable in plasma/serum. The aim of this study was to investigate the role of miR-421 in osteosarcoma. We found that the serum expression levels of miR-421 were significantly higher in osteosarcoma patients than those in healthy volunteers. Moreover, miR-421 expression was significantly higher in osteosarcoma tissues compared with that in the adjacent normal tissues. Meanwhile, the expression of miR-421 was upregulated in 90 % (36/40) osteosarcoma tissues compared to non-tumor tissues. More importantly, the expression levels of miR-421 in osteosarcoma tissues were correlated with those in patients’ serum. In addition, patients with high miR-421 expression had shorter overall survival (OS) than those with low expressions. We also found that overexpression of miR-421 promoted osteosarcoma cell line MG-63 proliferation, migration, and invasion. In conclusion, miR-421 expression levels were upregulated in osteosarcoma tissue and serum and it may be a useful marker for diagnosis of osteosarcoma.

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Titel: miR-421 is a diagnostic and prognostic marker in patients with osteosarcoma
verfasst von: Shuguang Zhou
Bing Wang
Jun Hu
Yucheng Zhou
Mengzhen Jiang
Mingyu Wu
Liming Qin
Xuming Yang
Publikationsdatum: 13.01.2016
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 7/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-4578-5

Springer Medizin

miR-421 is a diagnostic and prognostic marker in patients with osteosarcoma

Abstract

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Springer Medizin

Abstract

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