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Tumor Biology
Erschienen in: Tumor Biology 10/2016

28.07.2016 | Review

miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis

verfasst von: Chiranjib Chakraborty, Kok-Yong Chin, Srijit Das

Erschienen in: Tumor Biology | Ausgabe 10/2016

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Abstract

Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.
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Metadaten
Titel
miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis
verfasst von
Chiranjib Chakraborty
Kok-Yong Chin
Srijit Das
Publikationsdatum
28.07.2016
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 10/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-5156-1

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