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Diabetologia

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01.04.2007 | Commentary

Mitochondrial function: use it or lose it

verfasst von: J. A. Hawley, S. J. Lessard

Erschienen in: Diabetologia | Ausgabe 4/2007

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Excerpt

Type 2 diabetes is a progressive metabolic disorder that develops as a result of both environmental and undefined genetic factors [1]. While the precise molecular aetiology of this disorder remains elusive, there is general consensus that type 2 diabetes has several hallmark features: (1) a breakdown in lipid and carbohydrate metabolism, reflected by elevated levels of circulating metabolites and culminating in excessive deposition of fat in various tissues [2]; (2) skeletal muscle insulin resistance [3]; and (3) coordinated defects in oxidative metabolism [4‐6]. In conjunction with these altered metabolic states is the impaired insulin signalling observed in muscle of patients with type 2 diabetes [7]. At present, it is unclear whether these (and other) defects are a consequence of the diabetic state or are instrumental in its development. Unravelling this puzzle is made more difficult because these impairments do not occur in isolation but typically co-exist in the same individual. …

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Titel: Mitochondrial function: use it or lose it
verfasst von: J. A. Hawley
S. J. Lessard
Publikationsdatum: 01.04.2007
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 4/2007
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-007-0595-2

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