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Erschienen in:
18.10.2016 | Nephrology - Original Paper
Modification of the 2012 CKD-EPI equations for the elderly Chinese
Erschienen in: International Urology and Nephrology | Ausgabe 3/2017
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Background
Our previous studies demonstrated that 2012 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were inaccurate enough for estimating glomerular filtration rate in elderly Chinese. Thus, this study was constructed to modify these equations.
Methods
A total of 839 subjects (aged ≥60 years) from four hospitals in China between October 2009 and December 2014 were included. A random sample of 674 (80.3 %) subjects was used as a training sample set, and the remaining 165 (19.7 %) subjects as the verification set. The equations were modified using the hill-climbing algorithm.
Results
Compared with the original CKD-EPI equations, the accuracy assessment indexes (bias, precision, accuracy and misclassification) were obviously improved after modification. Bland–Altman analysis also demonstrated that this modification attempt gained success to some extent.
Conclusions
The modified 2012 CKD-EPI equations could be more accurate than the original equations for elderly Chinese individuals.